Chronomodulated Mucoadhesive Gastroretentive Drug Delivery System of Famotidine

Advances in Pharmacology and Pharmacy Vol. 10(3), pp. 209 - 217
DOI: 10.13189/app.2022.100307
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Haranath Chinthaginjala 1,*, Hindustan Abdul Ahad 2, Bhupalam Pradeepkumar 3
1 Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) -Autonomous, KR Palli Cross, Chiyyedu (PO), Anantapur-515721, Andhra Pradesh, India
2 Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) -Autonomous, KR Palli Cross, Chiyyedu (PO), Anantapur-515721, Andhra Pradesh, India
3 Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) -Autonomous, KR Palli Cross, Chiyyedu (PO), Anantapur-515721, Andhra Pradesh, India

ABSTRACT

In the present study, the main objective was to develop and evaluate a novel floating mucoadhesive drug delivery system for famotidine. In order to deliver drugs in accordance with circadian behavior, continuous drug delivery systems were developed. It represents that these systems will deliver the drug when the patient's condition is at most risk. The combination of floating behaviour with the formulation improves the gastric dosage residence. The method adopted for the preparation of tablets was press coating technology. Here it has two layers: a core layer and a coat layer. The core layer consists of active ingredients, and the coat possesses gas-generating agents and polymers like HPMC, Carbopol, and Pectin. The formulations were characterised for weight variation, friability, hardness, disintegration of core tablets, in vitro drug release studies and Ex vivo mucoadhesive studies. All the formulations manifested better results in terms of floating lag time, floating time of more than 8 hours and good adhesion property. The formulation F6 manifested drug release of 99.42% at the end of 7 hours. It was concluded that the formulation F6 is the best formulation which accomplishes the anticipated release with specific lag time and has the ability for off release followed by burst release which can effectively suppress nocturnal histamine level and hence suppress high nocturnal acid release.

KEYWORDS
Chronomodulated, Circadian, Famotidine, Floating, Mucoadhesive

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Haranath Chinthaginjala , Hindustan Abdul Ahad , Bhupalam Pradeepkumar , "Chronomodulated Mucoadhesive Gastroretentive Drug Delivery System of Famotidine," Advances in Pharmacology and Pharmacy, Vol. 10, No. 3, pp. 209 - 217, 2022. DOI: 10.13189/app.2022.100307.

(b). APA Format:
Haranath Chinthaginjala , Hindustan Abdul Ahad , Bhupalam Pradeepkumar (2022). Chronomodulated Mucoadhesive Gastroretentive Drug Delivery System of Famotidine. Advances in Pharmacology and Pharmacy, 10(3), 209 - 217. DOI: 10.13189/app.2022.100307.

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