Objective: To explore the feasibility and utility of a tolerance break (T-Break) guide on young adults' cannabis use. Participants: Young adults aged 18-29 (n=125) who were current cannabis users. Methods: Participants recruited through posters and listservs at various universities were offered the T-Break Guide (daily activities, advice, and encouragement) to help complete a 21-day cannabis break. Bivariate analyses examined associations between Guide use and follow-up measures. Results: Compared to non-Guide users, participants who used the Guide "a lot" were more likely to complete the 21-day abstinence break (84% vs. 57%), revise their personal definition of balance to mean less cannabis (84% vs. 62%), and plan a future break (32% vs. 11%). Conclusion: Use of this self-directed Guide may help young adults take a break from cannabis use and reduce future use. Further research using more rigorous designs to test the Guide's efficacy and assess longer-term maintenance of effects is needed.

This research was funded by a grant from the State of Vermont (TF). Effort of the authors was also supported by the National Institute on Drug Abuse of the National Institutes of Health under award numbers U54DA036114 (JAS), R21DA051943 (ACV), and P30DA029926 (AJB). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the State of Vermont. TF is the owner of Cum Laude Consulting LLC, which received a grant from the State of Vermont to investigate the T-Break Guide. Those funds were then subcontracted to the University of Vermont for this research.

NCT05382273

This research was funded by a grant from the State of Vermont (TF). Effort of the authors was also supported by the National Institute on Drug Abuse of the National Institutes of Health under award numbers U54DA036114 (JAS), R21DA051943 (ACV), and P30DA029926 (AJB). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the State of Vermont.

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