Sex differences in the relationships between body composition, fat distribution, and mitochondrial energy metabolism: a pilot study

Heymsfield SB, Wadden TA. Mechanisms, Pathophysiology, and Management of Obesity. N Engl J Med. 2017;376(3):254–66.

CAS  PubMed  Article  Google Scholar 

Okorodudu DO, Jumean MF, Montori VM, Romero-Corral A, Somers VK, Erwin PJ, et al. Diagnostic performance of body mass index to identify obesity as defined by body adiposity: a systematic review and meta-analysis. Int J Obesity (2005). 2010;34(5):791–9.

CAS  Article  Google Scholar 

Neeland IJ, Ross R, Despres JP, Matsuzawa Y, Yamashita S, Shai I, et al. Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement. Lancet Diabetes Endocrinol. 2019;7(9):715–25.

PubMed  Article  Google Scholar 

Karastergiou K, Smith SR, Greenberg AS, Fried SK. Sex differences in human adipose tissues—the biology of pear shape. Biol Sex Differ. 2012;3(1):13.

PubMed  PubMed Central  Article  Google Scholar 

Ventura-Clapier R, Moulin M, Piquereau J, Lemaire C, Mericskay M, Veksler V, et al. Mitochondria: a central target for sex differences in pathologies. Clin Sci (London, England:1979). 2017;131(9):803–22.

CAS  Article  Google Scholar 

Regitz-Zagrosek V, Oertelt-Prigione S, Prescott E, Franconi F, Gerdts E, Foryst-Ludwig A, et al. Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes. Eur Heart J. 2016;37(1):24–34.

CAS  PubMed  Article  Google Scholar 

Nasrallah CM, Horvath TL. Mitochondrial dynamics in the central regulation of metabolism. Nat Rev Endocrinol. 2014;10(11):650–8.

CAS  PubMed  Article  Google Scholar 

Willems PH, Rossignol R, Dieteren CE, Murphy MP, Koopman WJ. Redox homeostasis and mitochondrial dynamics. Cell Metab. 2015;22(2):207–18.

CAS  PubMed  Article  Google Scholar 

Bajpeyi S, Pasarica M, Moro C, Conley K, Jubrias S, Sereda O, et al. Skeletal muscle mitochondrial capacity and insulin resistance in type 2 diabetes. J Clin Endocrinol Metab. 2011;96(4):1160–8.

CAS  PubMed  PubMed Central  Article  Google Scholar 

De Mello AH, Costa AB, Engel JDG, Rezin GT. Mitochondrial dysfunction in obesity. Life Sci. 2018;192:26–32.

PubMed  Article  CAS  Google Scholar 

Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Molina AJ. Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: implications for a minimally invasive biomarker of mitochondrial health. Redox Biol. 2016;10:65–77.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Liu Y, Gu Y, Yu X. Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review. Quant Imaging Med Surg. 2017;7(6):707–26.

PubMed  PubMed Central  Article  Google Scholar 

Ferrick DA, Neilson A, Beeson C. Advances in measuring cellular bioenergetics using extracellular flux. Drug Discovery Today. 2008;13(5–6):268–74.

CAS  PubMed  Article  Google Scholar 

Bournat JC, Brown CW. Mitochondrial dysfunction in obesity. Curr Opin Endocrinol Diabetes Obes. 2010;17(5):446–52.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Lynam-Lennon N, Connaughton R, Carr E, Mongan AM, O’Farrell NJ, Porter RK, et al. Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma. BMC Cancer. 2014;14:907.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Chanseaume E, Barquissau V, Salles J, Aucouturier J, Patrac V, Giraudet C, et al. Muscle mitochondrial oxidative phosphorylation activity, but not content, is altered with abdominal obesity in sedentary men: synergism with changes in insulin sensitivity. J Clin Endocrinol Metab. 2010;95(6):2948–56.

CAS  PubMed  Article  Google Scholar 

O’Brien LC, Wade RC, Segal L, Chen Q, Savas J, Lesnefsky EJ, et al. Mitochondrial mass and activity as a function of body composition in individuals with spinal cord injury. Physiol Rep. 2017;5(3):e13080.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Lalia AZ, Dasari S, Johnson ML, Robinson MM, Konopka AR, Distelmaier K, et al. Predictors of whole-body insulin sensitivity across ages and adiposity in adult humans. J Clin Endocrinol Metab. 2016;101(2):626–34.

PubMed  Article  Google Scholar 

Bharadwaj MS, Tyrrell DJ, Leng I, Demons JL, Lyles MF, Carr JJ, et al. Relationships between mitochondrial content and bioenergetics with obesity, body composition and fat distribution in healthy older adults. BMC obesity. 2015;2:40.

PubMed  PubMed Central  Article  Google Scholar 

Johannsen DL, Conley KE, Bajpeyi S, Punyanitya M, Gallagher D, Zhang Z, et al. Ectopic lipid accumulation and reduced glucose tolerance in elderly adults are accompanied by altered skeletal muscle mitochondrial activity. J Clin Endocrinol Metab. 2012;97(1):242–50.

CAS  PubMed  Article  Google Scholar 

Willig AL, Kramer PA, Chacko BK, Darley-Usmar VM, Heath SL, Overton ET. Monocyte bioenergetic function is associated with body composition in virologically suppressed HIV-infected women. Redox Biol. 2017;12:648–56.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Chacko BK, Smith MR, Johnson MS, Benavides G, Culp ML, Pilli J, et al. Mitochondria in precision medicine; linking bioenergetics and metabolomics in platelets. Redox Biol. 2019;22:101165.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Goss AM, Gower BA. Insulin sensitivity is associated with thigh adipose tissue distribution in healthy postmenopausal women. Metab Clin Exp. 2012;61(12):1817–23.

CAS  PubMed  Article  Google Scholar 

Stefan DDCF, Andrasescu A, Popa E, Lazariev A, Vescovo E, Strbak O, Williams S, Starcuk Z, Cabanas M, van Ormondt D, Graveron-Demilly D. Quantitation of magnetic resonance spectroscopy signals: the jMRUI software package. Meas Sci Technol. 2009;20(104035):1–9.

Google Scholar 

Vanhamme L, van den Boogaart A, Van Huffel S. Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J Magn Resonance (San Diego, Calif:1997). 1997;129(1):35–43.

CAS  Article  Google Scholar 

Blei ML, Conley KE, Kushmerick MJ. Separate measures of ATP utilization and recovery in human skeletal muscle. J Physiol. 1993;465:203–22.

CAS  PubMed  PubMed Central  Article  Google Scholar 

McCully KK, Fielding RA, Evans WJ, Leigh JS Jr, Posner JD. Relationships between in vivo and in vitro measurements of metabolism in young and old human calf muscles. J Appl Physiol (Bethesda, Md:1985). 1993;75(2):813–9.

CAS  Article  Google Scholar 

Bellissimo MP, Cai Q, Ziegler TR, Liu KH, Tran PH, Vos MB, et al. Plasma high-resolution metabolomics differentiates adults with normal weight obesity from lean individuals. Obesity (Silver Spring, Md). 2019;27(11):1729–37.

CAS  Article  Google Scholar 

Group TI. Guidelines for Data Processing and Analysis of the International Physical Activity Questionnaire. 2005. http://www.ipaq.ki.se.

Schorr M, Dichtel LE, Gerweck AV, Valera RD, Torriani M, Miller KK, et al. Sex differences in body composition and association with cardiometabolic risk. Biol Sex Differ. 2018;9(1):28.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Tyrrell DJ, Bharadwaj MS, Van Horn CG, Marsh AP, Nicklas BJ, Molina AJ. Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults. Exp Gerontol. 2015;70:84–91.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Larson-Meyer DE, Newcomer BR, Hunter GR, McLean JE, Hetherington HP, Weinsier RL. Effect of weight reduction, obesity predisposition, and aerobic fitness on skeletal muscle mitochondrial function. Am J Physiol Endocrinol Metab. 2000;278(1):E153–61.

CAS  PubMed  Article  Google Scholar 

Bakkman L, Fernstrom M, Loogna P, Rooyackers O, Brandt L, Lagerros YT. Reduced respiratory capacity in muscle mitochondria of obese subjects. Obes Facts. 2010;3(6):371–5.

PubMed  PubMed Central  Google Scholar 

Patti ME, Corvera S. The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev. 2010;31(3):364–95.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Boettcher M, Machann J, Stefan N, Thamer C, Haring HU, Claussen CD, et al. Intermuscular adipose tissue (IMAT): association with other adipose tissue compartments and insulin sensitivity. J Magn Reson Imaging. 2009;29(6):1340–5.

PubMed  Article  Google Scholar 

Jheng HF, Tsai PJ, Guo SM, Kuo LH, Chang CS, Su IJ, et al. Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle. Mol Cell Biol. 2012;32(2):309–19.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Muir LA, Neeley CK, Meyer KA, Baker NA, Brosius AM, Washabaugh AR, et al. Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity. Obesity (Silver Spring, Md). 2016;24(3):597–605.

CAS  Article  Google Scholar 

Tchoukalova YD, Koutsari C, Karpyak MV, Votruba SB, Wendland E, Jensen MD. Subcutaneous adipocyte size and body fat distribution. Am J Clin Nutr. 2008;87(1):56–63.

CAS  PubMed  Article 

留言 (0)

沒有登入
gif