∗Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

†Department of Health Management, Army Medical Center of PLA, Chongqing, China

‡Department of Pharmacy, Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer Hospital, Chongqing, China

§Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

Address reprint requests to Chuanjiang Wang, MD, Chongqing Medical University, Chongqing, China. E-mail: [email protected]

Received 27 October, 2021

Revised 14 November, 2021

Accepted 1 February, 2022

Our manuscript confirming the study is reported in accordance with ARRIVE guidelines.

QW and XC contributed equally to this work.

This study was supported by National Natural Science Foundation grants of China (81803110, to QW), Basic science and cutting-edge technology research projects of Chongqing Science & Technology Commission (cstc2020jcyj-msxmX0014, to CJ-W) and the Medical Research Project of Chongqing City Health and Family Planning Committee (2020FYYX055, to CJ-W, 2021MSXM010, to ZZ-Y).

Ethics approval: Human subjects: This study was carried out in accordance with the recommendations of the Ethics Committee of the First Affiliated Hospital of Chongqing Medical University with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the Ethics Committee of the First Affiliated Hospital of Chongqing Medical University. The number is 2020–847. Animal subjects: This study was carried out in accordance with the recommendations of The Institutional Animal Care and Use Committee at Chongqing Medical University. All experimental protocols were approved by the Institutional Animal Care and Use Committee at Chongqing Medical University.

Consent for publication: We confirm that the manuscript has been read and approved by all named authors and that there are no other persons who satisfied the criteria for authorship but are not listed. We further confirm that the order of authors listed in the manuscript has been approved by all of us.

The authors report no conflicts of interest.

Authors’ contributions: Conception hypothesis and design: CJ-W. Data acquisition and analysis: QW. Manuscript preparation: XC. Revised manuscript: CJ-W. Searched and collected bibliography: XC and ZZ-Y.

The datasets used or analyzed during the current study are available from the corresponding author on reasonable request.