Effect of Rotavirus Infection on Serum Micronutrients and Atopy in Children

  SFX Search  Buy Article Permissions and Reprints Abstract

Objective Rotavirus is a highly infectious and prevalent ribonucleic acid (RNA) virus that causes fatal gastroenteritis in children. Despite vitamin D deficiency is associated with susceptibility to infections, the relationship between ferritin and vitamin B12 levels is not known. This study aimed to investigate and compare the effect of rotavirus on micronutrient levels, atopy, and the frequency of allergic diseases in children with rotavirus.

Methods There were rotavirus gastroenteritis (RVG) (N = 92) and non-rotavirus (control) groups (N = 95). Serum micronutrient levels (B12, ferritin, and 25-hydroxyvitamin D [25-OH-D3]) were checked during the first control after gastroenteritis healed. Patients were also examined for allergic diseases on an average of 17 (14–32) months following rotavirus infection. Serum immunoglobulin E (IgE), eosinophil count, and percentage were analyzed. Skin tests and respiratory function tests were also performed on patients with allergic disease and asthma symptoms.

Results Mean ferritin, B12, and 25-OH-D3 levels were lower in the RVG group compared with the control group. Allergic diseases in the RVG group were more frequent than in the control group. The prevalence of the allergic disease in the RVG group was 16.3%, as opposed to 5.2% in the control group (p = 0.014). The IgE level was significantly higher in the RVG group.

Conclusion Children with rotavirus infection should be followed closely in terms of allergic diseases and micronutrient deficiency. Furthermore, rotavirus infection should be prevented in the society and early treatment should be made available via tests detecting micronutrient deficiency.

Keywords ferritin - gastroenteritis - sensitivity - rotavirus Authors' Contributions

M.K.B., C.D., and F.O. contributed to the conception and design of this study. M.K.B. and C.D. collected the data. A.S. and F.O. contributed to analysis and interpretation of data. M.K.B., A.S., and F.O. performed the statistical analysis and drafted the manuscript and figures. M.K.B., A.S., C.D., and F.O. critically reviewed the manuscript and supervised the whole study process. All authors read and approved the final manuscript. All authors agree to be accountable for all aspects of work ensuring integrity and accuracy.

Publication History

Received: 09 December 2021

Accepted: 25 February 2022

Publication Date:
17 May 2022 (online)

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

留言 (0)

沒有登入
gif