Electrophysiology and Arrhythmia: Research Article
Yang Z. · Liu P. · Luo F. · Liu Y. · Lai J. · Cheng C. · Liu Q.Log in to MyKarger to check if you already have access to this content.
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Article / Publication Details AbstractIntroduction: Premature ventricular contractions (PVCs) were now well recognized to carry the risk of inducing left ventricular (LV) enlargement and were closely related to the cardiac autonomic nervous activity quantified by heart rate variability (HRV) analysis. However, the relationship between LV enlargement and HRV in patients with frequent PVCs is still unclear. This study aimed to investigate the risk factors and HRV for LV enlargement in patients with Frequent PVCs. Methods: Patients with frequent PVCs (n=571), whose PVC burden counts > 10000/24h or PVC burden > 10%, were recruited. Patients were divided into LV enlargement group (n=161), defined as female left ventricular end-diastolic diameter (LVEDD) > 49.8 mm or male LVEDD > 54.2 mm, and LV normal group (n=410). Two groups were compared on their clinical, electrocardiographic, and HRV parameters. Logistic regression analysis was used to predict the risk factors of LV enlargement in patients with frequent PVCs. The parameters of echocardiography, Holter monitoring, and HRV were collected after ablation. Results: There were significant differences between the patients with left enlargement and with normal LV structure, in terms of sex, left ventricular ejection fraction (LVEF), level of N-terminal pro-brain natriuretic peptide (NT-proBNP), 24-h PVCs burden, with non-sustained ventricular tachycardia, multifocal PVCs, QRS duration of PVC and values of very low-frequency power of HRV parameter (all p
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