Snaidero N, Simons M. Myelination at a glance. J Cell Sci. 2014;127(Pt 14):2999–3004.

CAS  PubMed  Article  Google Scholar 

Philips T, Rothstein JD. Oligodendroglia: metabolic supporters of neurons. J Clin Invest. 2017;127(9):3271–80.

PubMed  PubMed Central  Article  Google Scholar 

Pohl HB, Porcheri C, Mueggler T, Bachmann LC, Martino G, Riethmacher D, Franklin RJ, Rudin M, Suter U. Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage. J Neurosci. 2011;31(3):1069–80.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Ghosh A, Manrique-Hoyos N, Voigt A, Schulz JB, Kreutzfeldt M, Merkler D, Simons M. Targeted ablation of oligodendrocytes triggers axonal damage. PLoS ONE. 2011;6(7): e22735.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Oluich LJ, Stratton JA, Xing YL, Ng SW, Cate HS, Sah P, Windels F, Kilpatrick TJ, Merson TD. Targeted ablation of oligodendrocytes induces axonal pathology independent of overt demyelination. J Neurosci. 2012;32(24):8317–30.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Alizadeh A, Dyck SM, Karimi-Abdolrezaee S. Myelin damage and repair in pathologic CNS: challenges and prospects. Front Mol Neurosci. 2015;8:35.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Compston A, Coles A. Multiple sclerosis. Lancet. 2002;359(9313):1221–31.

PubMed  Article  Google Scholar 

Stys PK, Zamponi GW, van Minnen J, Geurts JJ. Will the real multiple sclerosis please stand up? Nat Rev Neurosci. 2012;13(7):507–14.

CAS  PubMed  Article  Google Scholar 

Dobson R, Giovannoni G. Multiple sclerosis - a review. Eur J Neurol. 2019;26(1):27–40.

CAS  PubMed  Article  Google Scholar 

Barnett MH, Prineas JW. Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion. Ann Neurol. 2004;55(4):458–68.

PubMed  Article  Google Scholar 

Prineas JW, Kwon EE, Cho ES, Sharer LR, Barnett MH, Oleszak EL, Hoffman B, Morgan BP. Immunopathology of secondary-progressive multiple sclerosis. Ann Neurol. 2001;50(5):646–57.

CAS  PubMed  Article  Google Scholar 

Ransohoff RM. Animal models of multiple sclerosis: the good, the bad and the bottom line. Nat Neurosci. 2012;15(8):1074–7.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Lassmann H, Bradl M. Multiple sclerosis: experimental models and reality. Acta Neuropathol. 2017;133(2):223–44.

CAS  PubMed  Article  Google Scholar 

Oleszak EL, Chang JR, Friedman H, Katsetos CD, Platsoucas CD. Theiler’s virus infection: a model for multiple sclerosis. Clin Microbiol Rev. 2004;17(1):174–207.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Robinson AP, Harp CT, Noronha A, Miller SD. The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment. Handb Clin Neurol. 2014;122:173–89.

PubMed  PubMed Central  Article  Google Scholar 

Skundric DS. Experimental models of relapsing-remitting multiple sclerosis: current concepts and perspective. Curr Neurovasc Res. 2005;2(4):349–62.

CAS  PubMed  Article  Google Scholar 

Sriram S, Steiner I. Experimental allergic encephalomyelitis: a misleading model of multiple sclerosis. Ann Neurol. 2005;58(6):939–45.

CAS  PubMed  Article  Google Scholar 

Zendedel A, Beyer C, Kipp M. Cuprizone-induced demyelination as a tool to study remyelination and axonal protection. J Mol Neurosci. 2013;51(2):567–72.

CAS  PubMed  Article  Google Scholar 

Blakemore WF, Franklin RJ. Remyelination in experimental models of toxin-induced demyelination. Curr Top Microbiol Immunol. 2008;318:193–212.

CAS  PubMed  Google Scholar 

Vega-Riquer JM, Mendez-Victoriano G, Morales-Luckie RA, Gonzalez-Perez O. Five decades of cuprizone, an updated model to replicate demyelinating diseases. Curr Neuropharmacol. 2019;17(2):129–41.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Hooijmans CR, Hlavica M, Schuler FAF, Good N, Good A, Baumgartner L, Galeno G, Schneider MP, Jung T, de Vries R, et al. Remyelination promoting therapies in multiple sclerosis animal models: a systematic review and meta-analysis. Sci Rep. 2019;9(1):822.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Plemel JR, Liu WQ, Yong VW. Remyelination therapies: a new direction and challenge in multiple sclerosis. Nat Rev Drug Discov. 2017;16(9):617–34.

CAS  PubMed  Article  Google Scholar 

Nilsson G, Erdtman H, Lindstedt G, Kinell P. A new colour reaction on copper and certain carbonyl compounds. Acta Chem Scand. 1950;4:205–205.

CAS  Article  Google Scholar 

Carlton WW. Studies on the induction of hydrocephalus and spongy degeneration by cuprizone feeding and attempts to antidote the toxicity. Life Sci. 1967;6(1):11–9.

CAS  PubMed  Article  Google Scholar 

Carlton WW. Response of mice to the chelating agents sodium diethyldithiocarbamate, alpha-benzoinoxime, and biscyclohexanone oxaldihydrazone. Toxicol Appl Pharmacol. 1966;8(3):512–21.

CAS  PubMed  Article  Google Scholar 

Suzuki K. Giant hepatic mitochondria: production in mice fed with cuprizone. Science. 1969;163(3862):81–2.

CAS  PubMed  Article  Google Scholar 

Kesterson JW, Carlton WW. Monoamine oxidase inhibition and the activity of other oxidative enzymes in the brains of mice fed cuprizone. Toxicol Appl Pharmacol. 1971;20(3):386–95.

CAS  PubMed  Article  Google Scholar 

Venturini G. Enzymic activities and sodium, potassium and copper concentrations in mouse brain and liver after cuprizone treatment in vivo. J Neurochem. 1973;21(5):1147–51.

CAS  PubMed  Article  Google Scholar 

Acs P, Selak MA, Komoly S, Kalman B. Distribution of oligodendrocyte loss and mitochondrial toxicity in the cuprizone-induced experimental demyelination model. J Neuroimmunol. 2013;262(1–2):128–31.

CAS  PubMed  Article  Google Scholar 

Hoppel CL, Tandler B. Biochemical effects of cuprizone on mouse liver and heart mitochondria. Biochem Pharmacol. 1973;22(18):2311–8.

CAS  PubMed  Article  Google Scholar 

Carlton WW. Spongiform encephalopathy induced in rats and guinea pigs by cuprizone. Exp Mol Pathol. 1969;10(3):274–87.

CAS  PubMed  Article  Google Scholar 

Silvestroff L, Bartucci S, Pasquini J, Franco P. Cuprizone-induced demyelination in the rat cerebral cortex and thyroid hormone effects on cortical remyelination. Exp Neurol. 2012;235(1):357–67.

CAS  PubMed  Article  Google Scholar 

Oakden W, Bock NA, Al-Ebraheem A, Farquharson MJ, Stanisz GJ. Early regional cuprizone-induced demyelination in a rat model revealed with MRI. NMR Biomed. 2017;30(9):e3743.

Article  CAS  Google Scholar 

Adamo AM, Paez PM, Escobar Cabrera OE, Wolfson M, Franco PG, Pasquini JM, Soto EF. Remyelination after cuprizone-induced demyelination in the rat is stimulated by apotransferrin. Exp Neurol. 2006;198(2):519–29.

CAS  PubMed  Article  Google Scholar 

Kanno T, Sasaki S, Yamada N, Kawasako K, Tsuchitani M. Hexachlorophene and cuprizone induce the spongy change of the developing rat brain by different mechanisms: the role of 2’, 3’-cyclic nucleotide 3’-phosphodiesterase (CNPase). J Vet Med Sci. 2012;74(7):837–43.

CAS  PubMed  Article  Google Scholar 

Buyukmihci N, Goehring-Harmon F, Marsh RF. Retinal degeneration during clinical scrapie encephalopathy in hamsters. J Comp Neurol. 1982;205(2):153–60.

CAS  PubMed  Article  Google Scholar 

Kimberlin RH, Collis SC, Walker CA. Profiles of brain glycosidase activity in cuprizone-fed Syrian hamsters and in scrapie-affected mice, rats, Chinese hamsters and Syrian hamsters. J Comp Pathol. 1976;86(1):135–42.

CAS  PubMed  Article  Google Scholar 

Chen Z, Chen JT, Johnson M, Gossman ZC, Hendrickson M, Sakaie K, Martinez-Rubio C, Gale JT, Trapp BD. Cuprizone does not induce CNS demyelination in nonhuman primates. Ann Clin Transl Neurol. 2015;2(2):208–13.

CAS  PubMed  Article  Google Scholar 

Kondo A, Nakano T, Suzuki K. Blood-brain barrier permeability to horseradish peroxidase in twitcher and cuprizone-intoxicated mice. Brain Res. 1987;425(1):186–90.

CAS  PubMed  Article  Google Scholar 

Bakker DA, Ludwin SK. Blood-brain barrier permeability during Cuprizone-induced demyelination. Implications for the pathogenesis of immune-mediated demyelinating diseases. J Neurol Sci. 1987;78(2):125–37.

CAS  PubMed