The IL-18/IL-18R1 signalling axis: Diagnostic and therapeutic potential in hypertension and chronic kidney disease

ANCA

Anti-neutrophil cytoplasmic antibodies

ASC

Apoptosis-associated speck like protein containing a caspase recruitment domain

CCL

Chemokine (C–C) motif ligand

CKD

Chronic kidney disease

CXCL

Chemokine (C-X-C motif) ligand

DAMP

Damage associated molecular pattern

DGF

Delayed graft function

DOCA

Deoxycorticosterone acetate

eGFR

Estimated glomerular filtration rate

ERK

Extracellular receptor kinase

ESKD

End-stage kidney disease

GFR

Glomerular filtration rate

ICAM

Intercellular adhesion molecule 1

IL-12R

Interleukin-12 receptor

IL-18BP

Interleukin-18 binding protein

IL-18R1

Interleukin-18 receptor

IL-18RAP

Interleukin-18 receptor accessory protein

IL-1R8

Interleukin-1 receptor 8

IL-23R

Interleukin-23 receptor

iNOS

Inducible nitric oxide synthase

IRI

Ischemia reperfusion injury

MAPK

Mitogen-activated protein kinase

MEK/ERK

Mitogen-activated protein kinase extracellular signal-regulated kinase

MyD88

Myeloid differentiation factor 88

NLRP3

Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein

NLRC4

Nucleotide-binding oligomerization domain-like receptor C4

PAMP

Pathogen associated molecular pattern

PI3K/Akt

Phosphoinositide-3-kinase–protein kinase B/Akt

PRR

Pattern recognition receptor

STAT

Signal transducer and activator of transcription

TEC

Tubular epithelial cells

TIR

Toll/interleukin-1 receptor

TNF-α

Tumour necrosis factor α

UUO

Unilateral ureteral obstruction

VCAM

Vascular adhesion molecule 1

留言 (0)

沒有登入
gif