Safety and Efficacy of Inpatient Diabetes Management with Non-insulin Agents: an Overview of International Practices

American Diabetes Association. Chapter 16. Diabetes care in the hospital: standards of medical care in diabetes-2022. Diabetes Care. 2022;45(Suppl_1):S244-S253

Umpierrez GE, Hellman R, Korytkowski MT, et al. Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2012;97(1):16–38.

CAS  PubMed  Article  Google Scholar 

Moghissi ES, Korytkowski MT, DiNardo M, et al. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. Diabetes Care. 2009;32(6):1119–31.

PubMed  PubMed Central  Article  Google Scholar 

Umpierrez GE, Isaacs SD, Bazargan N, You X, Thaler LM, Kitabchi AE. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab. 2002;87(3):978–82.

CAS  PubMed  Article  Google Scholar 

Bersoux S, Cook CB, Kongable GL, Shu J. Trends in glycemic control over a 2-year period in 126 US hospitals. J Hosp Med. 2013;8(3):121–5.

PubMed  Article  Google Scholar 

Cook CB, Kongable GL, Potter DJ, Abad VJ, Leija DE, Anderson M. Inpatient glucose control a glycemic survey of 126 US hospitals. J Hosp Med. 2009;4(9):7–14.

Article  Google Scholar 

Kosiborod MN, Esterline R, Furtado RHM, et al. Dapagliflozin in patients with cardiometabolic risk factors hospitalised with COVID-19 (DARE-19): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Diabetes Endocrinol. 2021;9(9):586–94.

CAS  PubMed  PubMed Central  Article  Google Scholar 

McAlister FA, Majumdar SR, Blitz S, Rowe BH, Romney J, Marrie TJ. The relation between hyperglycemia and outcomes in 2,471 patients admitted to the hospital with community-acquired pneumonia. Diabetes Care. 2005;28(4):810–5.

PubMed  Article  Google Scholar 

Migdal AL, Fortin-Leung C, Pasquel F, Wang H, Peng L, Umpierrez GE. Inpatient glycemic control with sliding scale insulin in noncritical patients with type 2 diabetes: who can slide? J Hosp Med. 2021;16(8):462–8.

PubMed  Article  Google Scholar 

Mulla I, Schmidt K, Cashy J, et al. Comparison of glycemic and surgical outcomes after change in glycemic targets in cardiac surgery patients. Diabetes Care. 2014;37(11):2960–5.

CAS  PubMed  Article  Google Scholar 

Schmeltz LR, DeSantis AJ, Thiyagarajan V, et al. Reduction of surgical mortality and morbidity in diabetic patients undergoing cardiac surgery with a combined intravenous and subcutaneous insulin glucose management strategy. Diabetes Care. 2007;30(4):823–8.

CAS  PubMed  Article  Google Scholar 

Swanson CM, Potter DJ, Kongable GL, Cook CB. Update on inpatient glycemic control in hospitals in the United States. Endocr Pract. 2011;17(6):853–61.

PubMed  Article  Google Scholar 

van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001;345(19):1359–67.

PubMed  Article  Google Scholar 

NHS Digital. National Diabetes Inpatient Audit (NaDIA). 2021. https://digital.nhs.uk/supplementary-information/2021/nadia-insulin-use-oral-hypoglycaemic-agent-use-insulin-infusion-use

Ena J, Gomez-Huelgas R, Romero-Sanchez M, et al. Hyperglycemia management in patients admitted to internal medicine in Spain: A point-prevalence survey examining adequacy of glycemic control and guideline adherence. Eur J Intern Med. 2015;26(6):392–8.

PubMed  Article  Google Scholar 

Ghosh S, Manley SE, Nightingale PG, et al. Prevalence of admission plasma glucose in “diabetes” or “at risk” ranges in hospital emergencies with no prior diagnosis of diabetes by gender, age and ethnicity. Endocrinol Diabetes Metab. 2020;3(3):e00140.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Evans NR, Dhatariya KK. Assessing the relationship between admission glucose levels, subsequent length of hospital stay, readmission and mortality. Clin Med (Lond). 2012;12(2):137–9.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Galindo RJ, Fayfman M, Umpierrez GE. Perioperative management of hyperglycemia and diabetes in cardiac surgery patients. Endocrinol Metab Clin North Am. 2018;47(1):203–22.

PubMed  PubMed Central  Article  Google Scholar 

Centers for Disease Control and Prevention. National Diabetes Statistics Report, 2020. US Dept of Health and Human Services. 2020.

Soriguer F, Goday A, Bosch-Comas A, et al. Prevalence of diabetes mellitus and impaired glucose regulation in Spain: the Di@bet.es Study. Diabetologia. 2012;55(1):88–93.

CAS  PubMed  Article  Google Scholar 

Kosiborod M, Inzucchi SE, Spertus JA, et al. Elevated admission glucose and mortality in elderly patients hospitalized with heart failure. Circulation. 2009;119(14):1899–907.

CAS  PubMed  Article  Google Scholar 

Sadhu AR, Patham B, Vadhariya A, Chikermane SG, Johnson ML. Outcomes of “real-world” insulin strategies in the management of hospital hyperglycemia. J Endocr Soc. 2021;5(8):bvab101.

PubMed  PubMed Central  Article  Google Scholar 

Queale WS, Seidler AJ, Brancati FL. Glycemic control and sliding scale insulin use in medical inpatients with diabetes mellitus. Arch Intern Med. 1997;157(5):545–52.

CAS  PubMed  Article  Google Scholar 

Gearhart JG, Duncan JL 3rd, Replogle WH, Forbes RC, Walley EJ. Efficacy of sliding-scale insulin therapy: a comparison with prospective regimens. Fam Pract Res J. 1994;14(4):313–22.

CAS  PubMed  Google Scholar 

Van den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006;354(5):449–61.

PubMed  Article  Google Scholar 

Sugar Investigators NICE, Finfer S, Chittock DR, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360(13):1283–97.

Article  Google Scholar 

Umpierrez GE, Smiley D, Zisman A, et al. Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes (RABBIT 2 trial). Diabetes Care. 2007;30(9):2181–6.

CAS  PubMed  Article  Google Scholar 

Umpierrez GE, Smiley D, Jacobs S, et al. Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes undergoing general surgery (RABBIT 2 surgery). Diabetes Care. 2011;34(2):256–61.

CAS  PubMed  PubMed Central  Article  Google Scholar 

• Christensen MB, Gotfredsen A, Norgaard K. Efficacy of basal-bolus insulin regimens in the inpatient management of non-critically ill patients with type 2 diabetes: a systematic review and meta-analysis. Diabetes Metab Res Rev. 2017;33(5). This meta-analysis concluded that basal-bolus insulin regimen results in lower mean glucose compared to sliding scale, but it's associated with increased risk of hypoglycemia.

Colunga-Lozano LE, Gonzalez Torres FJ, Delgado-Figueroa N, et al. Sliding scale insulin for non-critically ill hospitalised adults with diabetes mellitus. Cochrane Database Syst Rev. 2018;11:011296.

Google Scholar 

Umpierrez GE, Palacio A, Smiley D. Sliding scale insulin use: myth or insanity? Am J Med. 2007;120(7):563–7.

PubMed  Article  Google Scholar 

Perez Perez A, Conthe Gutierrez P, Aguilar Diosdado M, et al. Hospital management of hyperglycemia. Med Clin (Barc). 2009;132(12):465–75.

Article  Google Scholar 

Sampson M, Jones C, Joint British Diabetes Societies for Inpatient C. Joint British Diabetes Societies for Inpatient Care clinical guidelines and improving inpatient diabetes care. Diabet Med. 2018;35(8):988–91.

CAS  PubMed  Article  Google Scholar 

Qaseem A, Humphrey LL, Chou R, Snow V, Shekelle P. Clinical Guidelines Committee of the American College of P Use of intensive insulin therapy for the management of glycemic control in hospitalized patients a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2011;154(4):260–7.

PubMed  Article  Google Scholar 

Jacobi J, Bircher N, Krinsley J, et al. Guidelines for the use of an insulin infusion for the management of hyperglycemia in critically ill patients. Crit Care Med. 2012;40(12):3251–76.

PubMed  Article  Google Scholar 

Haque WZ, Demidowich AP, Sidhaye A, Golden SH, Zilbermint M. The Financial impact of an inpatient diabetes management service. Curr Diab Rep. 2021;21(2):5.

PubMed  PubMed Central  Article  Google Scholar 

Sampson MJ, Crowle T, Dhatariya K, et al. Trends in bed occupancy for inpatients with diabetes before and after the introduction of a diabetes inpatient specialist nurse service. Diabet Med. 2006;23(9):1008–15.

CAS  PubMed  Article  Google Scholar 

Rutter CL, Jones C, Dhatariya KK, et al. Determining in-patient diabetes treatment satisfaction in the UK–the DIPSat study. Diabet Med. 2013;30(6):731–8.

CAS  PubMed  Article  Google Scholar 

Mendez CE, Umpierrez GE. Management of type 1 diabetes in the hospital setting. Curr Diab Rep. 2017;17(10):98.

PubMed  Article  Google Scholar 

Galindo RJ, Umpierrez GE, Rushakoff RJ, et al. Continuous glucose monitors and automated insulin dosing systems in the hospital consensus guideline. J Diabetes Sci Technol. 2020;14(6):1035–64.

PubMed  PubMed Central  Article  Google Scholar 

Grunberger G, Sherr J, Allende M, et al. American Association of Clinical Endocrinology Clinical Practice Guideline: the use of advanced technology in the management of persons with diabetes mellitus. Endocr Pract. 2021;27(6):505–37.

PubMed  Article  Google Scholar 

Boughton CK, Bally L, Martignoni F, et al. Fully closed-loop insulin delivery in inpatients receiving nutritional support: a two-centre, open-label, randomised controlled trial. Lancet Diabetes Endocrinol. 2019;7(5):368–77.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Boughton CK, Daly A, Thabit H, et al. Day-to-day variability of insulin requirements in the inpatient setting: observations during fully closed-loop insulin delivery. Diabetes Obes Metab. 2021;23(8):1978–82.

CAS  PubMed  Article  Google Scholar 

Sultana G, Kapur P, Aqil M, Alam MS, Pillai KK. Drug utilization of oral hypoglycemic agents in a university teaching hospital in India. J Clin Pharm Ther. 2010;35(3):267–77.

CAS  PubMed  Article  Google Scholar 

Rajendran R, Kerry C, Rayman G, Ma GICsg. Temporal patterns of hypoglycaemia and burden of sulfonylurea-related hypoglycaemia in UK hospitals: a retrospective multicentre audit of hospitalised patients with diabetes. BMJ Open. 2014;4(7):e005165.

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