Hunt SD, Stephens DJ (2011) The role of motor proteins in endosomal sorting. Biochem Soc Trans 39(5):1179–1184
CAS PubMed Article Google Scholar
Simons M, Gordon E, Claesson-Welsh L (2016) Mechanisms and regulation of endothelial VEGF receptor signalling. Nat Rev Mol Cell Biol 17(10):611–625
CAS PubMed Article Google Scholar
Kempers L et al (2021) The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis. Angiogenesis 24(3):695–714
CAS PubMed PubMed Central Article Google Scholar
Agola JO et al (2011) Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities. Clin Genet 80(4):305–318
CAS PubMed PubMed Central Article Google Scholar
Mizuno-Yamasaki E, Rivera-Molina F, Novick P (2012) GTPase networks in membrane traffic. Annu Rev Biochem 81:637–659
CAS PubMed PubMed Central Article Google Scholar
Muller MP, Goody RS (2018) Molecular control of Rab activity by GEFs, GAPs and GDI. Small GTPases 9(1–2):5–21
PubMed Article CAS Google Scholar
Grosshans BL, Ortiz D, Novick P (2006) Rabs and their effectors: achieving specificity in membrane traffic. Proc Natl Acad Sci USA 103(32):11821–11827
CAS PubMed PubMed Central Article Google Scholar
Homma Y, Hiragi S, Fukuda M (2021) Rab family of small GTPases: an updated view on their regulation and functions. FEBS J 288(1):36–55
CAS PubMed Article Google Scholar
Stenmark H (2009) Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol 10(8):513–525
CAS PubMed Article Google Scholar
Hutagalung AH, Novick PJ (2011) Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev 91(1):119–149
CAS PubMed Article Google Scholar
Pfeffer SR (2017) Rab GTPases: master regulators that establish the secretory and endocytic pathways. Mol Biol Cell 28(6):712–715
CAS PubMed PubMed Central Article Google Scholar
Chappell JC, Wiley DM, Bautch VL (2012) How blood vessel networks are made and measured. Cells Tissues Organs 195(1–2):94–107
Arima S et al (2011) Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement. Development 138(21):4763–4776
CAS PubMed Article Google Scholar
Arroyo AG, Iruela-Arispe ML (2010) Extracellular matrix, inflammation, and the angiogenic response. Cardiovasc Res 86(2):226–235
CAS PubMed PubMed Central Article Google Scholar
Ballermann BJ, Obeidat M (2014) Tipping the balance from angiogenesis to fibrosis in CKD. Kidney Int Suppl (2011) 4(1):45–52
Bazzoni G, Dejana E (2004) Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev 84(3):869–901
CAS PubMed Article Google Scholar
Carmeliet P, Jain RK (2011) Molecular mechanisms and clinical applications of angiogenesis. Nature 473(7347):298–307
CAS PubMed PubMed Central Article Google Scholar
Xie Y et al (2019) Regulation of VEGFR2 trafficking and signaling by Rab GTPase-activating proteins. Sci Rep 9(1):13342
PubMed PubMed Central Article CAS Google Scholar
Smith GA et al (2016) VEGFR2 trafficking, signaling and proteolysis is regulated by the ubiquitin isopeptidase USP8. Traffic 17(1):53–65
CAS PubMed Article Google Scholar
Simons M (2012) An inside view: VEGF receptor trafficking and signaling. Physiology (Bethesda) 27(4):213–222
Basagiannis D et al (2017) Dynasore impairs VEGFR2 signalling in an endocytosis-independent manner. Sci Rep 7(1):45035
CAS PubMed PubMed Central Article Google Scholar
Basagiannis D et al (2016) VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation through macropinocytosis. J Cell Sci 129(21):4091–4104
Jopling HM et al (2014) Endosome-to-plasma membrane recycling of VEGFR2 receptor tyrosine kinase regulates endothelial function and blood vessel formation. Cells 3(2):363–385
CAS PubMed PubMed Central Article Google Scholar
Gampel A et al (2006) VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment. Blood 108(8):2624–2631
CAS PubMed Article Google Scholar
Labrecque L et al (2003) Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol. Mol Biol Cell 14(1):334–347
CAS PubMed PubMed Central Article Google Scholar
Singh V, Lamaze C (2020) Membrane tension buffering by caveolae: a role in cancer? Cancer Metastasis Rev 39(2):505–517
CAS PubMed Article Google Scholar
Sinha B et al (2011) Cells respond to mechanical stress by rapid disassembly of caveolae. Cell 144(3):402–413
CAS PubMed PubMed Central Article Google Scholar
Lanzetti L et al (2004) Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases. Nature 429(6989):309–314
CAS PubMed Article Google Scholar
Goh LK, Sorkin A (2013) Endocytosis of receptor tyrosine kinases. Cold Spring Harb Perspect Biol 5(5):a017459
PubMed PubMed Central Article CAS Google Scholar
Saxena S et al (2005) The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkA. J Neurosci 25(47):10930–10940
CAS PubMed PubMed Central Article Google Scholar
Vanlandingham PA, Ceresa BP (2009) Rab7 regulates late endocytic trafficking downstream of multivesicular body biogenesis and cargo sequestration. J Biol Chem 284(18):12110–12124
CAS PubMed PubMed Central Article Google Scholar
Pinilla-Macua I et al (2017) EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo. Elife 6:e31993
PubMed PubMed Central Article Google Scholar
Gao H, Shi W, Freund LB (2005) Mechanics of receptor-mediated endocytosis. Proc Natl Acad Sci USA 102(27):9469–9474
CAS PubMed PubMed Central Article Google Scholar
Kumari S, Mg S, Mayor S (2010) Endocytosis unplugged: multiple ways to enter the cell. Cell Res 20(3):256–275
CAS PubMed Article Google Scholar
Gourlaouen M et al (2013) Essential role for endocytosis in the growth factor-stimulated activation of ERK1/2 in endothelial cells. J Biol Chem 288(11):7467–7480
CAS PubMed PubMed Central Article Google Scholar
Yoshioka K et al (2012) Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Nat Med 18(10):1560–1569
CAS PubMed Article Google Scholar
Bhattacharya R et al (2005) Regulatory role of dynamin-2 in VEGFR-2/KDR-mediated endothelial signaling. FASEB J 19(12):1692–1694
CAS PubMed Article Google Scholar
Basagiannis D, Christoforidis S (2016) Constitutive endocytosis of VEGFR2 protects the receptor against shedding. J Biol Chem 291(32):16892–16903
CAS PubMed PubMed Central Article Google Scholar
Hsu C et al (2010) Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. J Cell Biol 189(2):223–232
CAS PubMed PubMed Central Article Google Scholar
Itoh T, Fukuda M (2006) Identification of EPI64 as a GTPase-activating protein specific for Rab27A. J Biol Chem 281(42):31823–31831
CAS PubMed Article Google Scholar
Kofler N et al (2018) The Rab-effector protein RABEP2 regulates endosomal trafficking to mediate vascular endothelial growth factor receptor-2 (VEGFR2)-dependent signaling. J Biol Chem 293(13):4805–4817
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