Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults

Elsevier

Available online 20 April 2022, 200237

Tumour Virus ResearchAbstractBackground

HIV has been shown to increase the likelihood of oral HPV infection. In this study, we evaluated the risk of oral HPV in HIV infected patients compared with HIV-negative controls.

Methods

101 healthy adult volunteers (HIV-) and 245 adults living with HIV infection (HIV+) were recruited from 5 academic medical centers. Questionnaires and saliva samples were obtained every 3-8 months over a period of 2 years (2015-2017). DNA was isolated from the saliva samples and tested for 18 high- and low-risk genotypes.

Results

Oral HPV was detected in 23% of HIV+ vs. 10% of HIV- participants (p<0.0001). Men had a higher oral HPV prevalence than women (27% vs. 15% HIV+, p=0.03, 16% vs. 5% HIV-, p=0.01). Risk factors among HIV+ participants included more lifetime deep kissing and oral sex partners, and history of AIDS. Persistent oral HPV was detected in 23% of HIV+ vs. 5% of HIV- participants (p<0.001). Among 8 HIV+ participants with CD4 counts <200 cell/μL none had cleared their HPV infection during the study.

Conclusions

Risk of oral HPV infection and persistence was significantly higher in HIV+ adults with a history of poorly controlled HIV, which may put them at increased risk of HPV-associated cancer.

Key words

human papillomavirus

human immunodeficiency virus

oral cavity

HPV prevalence

HPV

incidence

HPV clearance

© 2022 The Author(s). Published by Elsevier B.V.

留言 (0)

沒有登入
gif