Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(1):57-62 | DOI: 10.5507/bp.2020.034

Jan Bardona, Sandra Kurcovaa, Monika Chudackovaa, Pavel Otrubaa, David Krahulikb, Martin Nevrlya, Petr Kanovskya, Jana Zapletalovac, Jan Valoseka, d, Petr Hlustika, Miroslav Vastika, Marketa Vecerkovaa, Lenka Hvizdosovaa, Katerina Mensikovaa, Egon Kurcae, Stefan Sivake a Department of Neurology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic b Department of Neurosurgery, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic c Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic d Department of Biomedical Engineering, University Hospital Olomouc, Czech Republic e Department of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava and University Hospital Martin, Martin, Slovak Republic

Background: In this study we evaluated the impact of location of deep brain stimulation electrode active contact in different parts of the subthalamic nucleus on improvement of non-motor symptoms in patients with Parkinson's disease.

Methods: The subthalamic nucleus was divided into two (dorsolateral/ventromedial) and three (dorsolateral, medial, ventromedial) parts. 37 deep brain stimulation electrodes were divided according to their active contact location. Correlation between change in non-motor symptoms before and one and four months after deep brain stimulation electrode implantation and the location of active contact was made.

Results: In dividing the subthalamic nucleus into three parts, no electrode active contact was placed ventromedially, 28 active contacts were located in the medial part and 9 contacts were placed dorsolaterally. After one and four months, no significant difference was found between medial and dorsolateral positions. In the division of the subthalamic nucleus into two parts, 13 contacts were located in the ventromedial part and 24 contacts were placed in the dorsolateral part. After one month, significantly greater improvement in the Non-motor Symptoms Scale for Parkinson's disease (P=0.045) was found on dorsolateral left-sided stimulation, but no significant differences between the ventromedial and dorsolateral positions were found on the right side.

Conclusion: This study demonstrated the relationship between improvement of non-motor symptoms and the side (hemisphere, left/right) of the deep brain stimulation electrode active contact, rather than its precise location within specific parts of the subthalamic nucleus in patients treated for advanced Parkinson's disease.

Keywords: non-motor symptoms, Parkinson's disease, deep brain stimulation

Bardon, J., Kurcova, S., Chudackova, M., Otruba, P., Krahulik, D., Nevrly, M., ... Sivak, S. (2022). Deep brain stimulation electrode position impact on parkinsonian non-motor symptoms. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub.,166(1),57-62. doi:10.5507/bp.2020.034

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