Advances in Pharmacology and Pharmacy Vol. 10(2), pp. 128 - 137
DOI: 10.13189/app.2022.100207
Reprint (PDF) (360Kb)

J. Josephine Leno Jenita 1,*, Jahnavi Kulkarni 1, Agasa Ramu Mahesh 2, Shanaz Banu 3, Seema S. Rathore 1, Manjula D 1
1 Department of Pharmaceutics, College of Pharmaceutical Sciences, Dayananda Sagar University, Bangalore- 560078, Karnataka, India
2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore- 560054, Karnataka, India
3 Department of Pharmacognosy, College of Pharmaceutical Sciences, Dayananda Sagar University, Bangalore- 560078, Karnataka, India

ABSTRACT

Protein kinases play a prominent role in transferring a phosphate group from ATP (adenosine triphosphate) to serine, tyrosine, or threonine residues. Mutation and dysregulation in their activity lead to an imbalance in the health causing diseases like cancer. Protein kinase inhibitors have proved to be more effective in addressing such impairment caused by the dysregulation of protein kinases. Several protein kinase inhibitors like antibodies and small molecules have been approved by the regulatory bodies like US FDA, and many of them are being developed and expected to enter the clinical trials and subsequently to the market in the near future. However, targeting such kinase inhibitors to the desired site of action remains a challenging process. The current review focuses on the applicability of Nano platforms for targeting protein kinase inhibitors to the desired site of action and thus enhancing the therapeutic efficacy of the drug molecules against cancer. Besides, it also gives a brief idea to the readers about the imaging nanoplatforms investigated for the detection of protein kinase inhibitor activity along with the list of ongoing clinical trials pertaining to protein kinase inhibitors.

KEYWORDS
Protein Kinase Inhibitors, Nanoplatforms, Cancer, Potential Target

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] J. Josephine Leno Jenita , Jahnavi Kulkarni , Agasa Ramu Mahesh , Shanaz Banu , Seema S. Rathore , Manjula D , "Exposition of Protein Kinase Targeted Nanoplatforms: An Extensive Review," Advances in Pharmacology and Pharmacy, Vol. 10, No. 2, pp. 128 - 137, 2022. DOI: 10.13189/app.2022.100207.

(b). APA Format:
J. Josephine Leno Jenita , Jahnavi Kulkarni , Agasa Ramu Mahesh , Shanaz Banu , Seema S. Rathore , Manjula D (2022). Exposition of Protein Kinase Targeted Nanoplatforms: An Extensive Review. Advances in Pharmacology and Pharmacy, 10(2), 128 - 137. DOI: 10.13189/app.2022.100207.