Transanal Endoscopic Microsurgical Submucosal Dissection for Recurrent Rectal Adenomas

Small and Large Bowel: Research Article

Kouladouros K.a· Baral J.b

Author affiliations

aCentral Interdisciplinary Endoscopy Department, Mannheim University Hospital, University of Heidelberg, Mannheim, Germany
bSurgery Department, Karlsruhe Municipal Hospital, Karlsruhe, Germany

Log in to MyKarger to check if you already have access to this content.

Buy FullText & PDF Unlimited re-access via MyKarger Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.

Save over 20% compared to the individual article price.

Learn more

Rent/Cloud Rent for 48h to view Buy Cloud Access for unlimited viewing via different devices Synchronizing in the ReadCube Cloud Printing and saving restrictions apply Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe Access to all articles of the subscribed year(s) guaranteed for 5 years Unlimited re-access via Subscriber Login or MyKarger Unrestricted printing, no saving restrictions for personal use read more

Subcription rates

Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview

Abstract of Small and Large Bowel: Research Article

Received: November 12, 2021
Accepted: February 14, 2022
Published online: February 24, 2022

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 0257-2753 (Print)
eISSN: 1421-9875 (Online)

For additional information: https://www.karger.com/DDI

Abstract

Background: The local resection of recurrent rectal adenomas is a technically challenging task associated with increased local recurrence rate. Transanal endoscopic microsurgical submucosal dissection (TEM-ESD) uses traction to better expose the fibrotic submucosal layer, and therefore, is a valuable alternative for the treatment of such lesions. The aim of our study was to assess the feasibility and outcomes of TEM-ESD for the resection of recurrent rectal adenomas. Methods: We retrospectively analysed all TEM-ESD procedures performed in the Karlsruhe Municipal Hospital between 2012 and 2021 and isolated all cases of recurrent adenomas. Subsequently, we matched these cases 1:1 to TEM-ESD cases for primary rectal adenomas according to the size, localization, and histological type of the lesions and compared the outcomes between the two groups. Results: We identified 19 cases matching our criteria. The median diameter of the lesions was 25 mm and the median operating time 39 min. Macroscopic en bloc resection was achieved in 100% of the cases and histological complete en bloc resection in 78.9%. There was 1 case of conservatively treated postoperative bleeding. After a median follow-up period of 36 months, there was one local recurrence. After comparing those findings to the outcomes of TEM-ESD for primary rectal lesions, we found no significant differences on total operating time, complete en bloc resection rates, adverse events, and local recurrence. Conclusion: TEM-ESD is a feasible therapeutic option for the resection of recurrent rectal adenomas, offering short operating times as well as high en bloc resection and low recurrence rates.

© 2022 S. Karger AG, Basel

References Seo M, Dong-Hoon Y, Kim J, Song EM, Kim GU, Hwang SW, et al. Clinical outcomes of colorectal endoscopic submucosal dissection and risk factors associated with piecemeal resection. Turk J Gastroenterol. 2018 Jul;29(4):473–80. Yamada M, Saito Y, Takamaru H, Sasaki H, Yokota T, Matsuyama Y, et al. Long-term clinical outcomes of endoscopic submucosal dissection for colorectal neoplasms in 423 cases: a retrospective study. Endoscopy. 2017 Mar;49(3):233–42. Probst A, Ebigbo A, Märkl B, Schaller T, Anthuber M, Fleischmann C, et al. Endoscopic submucosal dissection for early rectal neoplasia: experience from a European center. Endoscopy. 2017 Mar;49(3):222–32. Moss A, Williams S, Hourigan L, Brown G, Tam W, Singh R, et al. Long-term adenoma recurrence following wide-field endoscopic mucosal resection (WF-EMR) for advanced colonic mucosal neoplasia is infrequent: results and risk factors in 1,000 cases from the Australian Colonic EMR (ACE) study. Gut. 2015 Jan;64(1):57–65. Pellise M, Burgess NG, Tutticci N, Hourigan LF, Zanati SA, Brown GJ, et al. Endoscopic mucosal resection for large serrated lesions in comparison with adenomas: a prospective multicentre study of 2,000 lesions. Gut. 2017 Apr;66(4):644–53. Knabe M, Pohl J, Gerges C, Ell C, Neuhaus H, Schumacher B. Standardized long-term follow-up after endoscopic resection of large, nonpedunculated colorectal lesions: a prospective two-center study. Am J Gastroenterol. 2014 Feb;109(2):183–9. Tate DJ, Desomer L, Klein A, Brown G, Hourigan LF, Lee EYT, et al. Adenoma recurrence after piecemeal colonic EMR is predictable: the Sydney EMR recurrence tool. Gastrointest Endosc. 2017 Mar;85(3):647–56.e6. Komeda Y, Watanabe T, Sakurai T, Kono M, Okamoto K, Nagai T, et al. Risk factors for local recurrence and appropriate surveillance interval after endoscopic resection. World J Gastroenterol. 2019;25(12):1502–12. Baral J. Transanal endoscopic microsurgical submucosa dissection in the treatment of rectal adenomas and T1 rectal cancer. Coloproctology. 2018 Oct;40(5):364–72. S3-leitlinie kolorektales karzinom. 2017 [cited 2018 May 11]. Available from: http://www.awmf.org/uploads/tx_szleitlinien/021-007OLl_S3_KRK_2017-12_1.pdf. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6,336 patients and results of a survey. Ann Surg. 2004;240(2):205–13. Rahmi G, Tanaka S, Ohara Y, Ishida T, Yoshizaki T, Morita Y, et al. Efficacy of endoscopic submucosal dissection for residual or recurrent superficial colorectal tumors after endoscopic mucosal resection. J Dig Dis. 2015;16(1):14–21. Shahidi N, Vosko S, Gupta S, van Hattem W, Sidhu M, Tate D, et al. Previously attempted large nonpedunculated colorectal polyps are effectively managed by endoscopic mucosal resection. Am J Gastroenterol. 2021 May;116(5):958–66. Sakamoto T, Saito Y, Matsuda T, Fukunaga S, Nakajima T, Fujii T. Treatment strategy for recurrent or residual colorectal tumors after endoscopic resection. Surg Endosc. 2011;25(1):255–60. Suzuki T, Kitagawa Y, Nankinzan R, Hara T, Yamaguchi T. Feasibility of endoscopic submucosal dissection for recurrent colorectal tumors after endoscopic mucosal resection. Acta Gastroenterol Belg. 2019 Jul–Sep;82(3):375–8. Kuroki Y, Hoteya S, Mitani T, Yamashita S, Kikuchi D, Fujimoto A, et al. Endoscopic submucosal dissection for residual/locally recurrent lesions after endoscopic therapy for colorectal tumors. J Gastroenterol Hepatol. 2010;25(11):1747–53. Veerappan SG, Ormonde D, Yusoff IF, Raftopoulos SC. Hot avulsion: a modification of an existing technique for management of nonlifting areas of a polyp (with video). Gastrointest Endosc. 2014;80(5):884–8. Tate DJ, Bahin FF, Desomer L, Sidhu M, Gupta V, Bourke MJ. Cold-forceps avulsion with adjuvant snare-tip soft coagulation (CAST) is an effective and safe strategy for the management of non-lifting large laterally spreading colonic lesions. Endoscopy. 2018 Jan;50(1):52–62. Chedgy FJ, Bhattacharyya R, Kandiah K, Longcroft-Wheaton G, Bhandari P. Knife-assisted snare resection: a novel technique for resection of scarred polyps in the colon. Endoscopy. 2016 Mar;48(3):277–80. Tsiamoulos ZP, Bourikas LA, Saunders BP. Endoscopic mucosal ablation: a new argon plasma coagulation/injection technique to assist complete resection of recurrent, fibrotic colon polyps (with video). Gastrointest Endosc. 2012 Feb;75(2):400–4. Ito S, Hotta K, Imai K, Yamaguchi Y, Kishida Y, Takizawa K, et al. Treatment strategy for local recurrences after endoscopic resection of a colorectal neoplasm. Surg Endosc. 2019 Apr;33(4):1140–6. Stadler A, Knabe M, May A. Endoscopic resection of a scarred rectal adenoma using EndoRotor. Z Gastroenterol. 2019;57(10):1226–9. Yokoi C, Gotoda T, Hamanaka H, Oda I. Endoscopic submucosal dissection allows curative resection of locally recurrent early gastric cancer after prior endoscopic mucosal resection. Gastrointest Endosc. 2006 Aug;64(2):212–8. Tanaka S, Kashida H, Saito Y, Yahagi N, Yamano H, Saito S, et al. JGES guidelines for colorectal endoscopic submucosal dissection/endoscopic mucosal resection. Dig Endosc. 2015 May;27(4):417–34. Matsumoto A, Tanaka S, Oba S, Kanao H, Oka S, Yoshihara M, et al. Outcome of endoscopic submucosal dissection for colorectal tumors accompanied by fibrosis. Scand J Gastroenterol. 2010 Nov;45(11):1329–37. Meier B, Caca K, Schmidt A. Hybrid endoscopic mucosal resection and full-thickness resection: a new approach for resection of large non-lifting colorectal adenomas (with video). Surg Endosc. 2017 Oct;31(10):4268–74. Ghersi S, Bassi M, Landi S, Binda C, Dabizzi E, Cennamo V. One-session combined technique for a recurrent rectal polyp: submucosal dissection and endoscopic full-thickness resection. Endoscopy. 2019;51(5):E120–1. Ramkumar J, Letarte F, Karimuddin AA, Phang PT, Raval MJ, Brown CJ. Assessing the safety and outcomes of repeat transanal endoscopic microsurgery. Surg Endosc. 2019 Jun;33(6):1976–80. Platell C, Denholm E, Makin G. Efficacy of transanal endoscopic microsurgery in the management of rectal polyps. J Gastroenterol Hepatol. 2004;19(7):767–72. Lev-Chelouche D, Margel D, Goldman G, Rabau MJ. Transanal endoscopic microsurgery: experience with 75 rectal neoplasms. Dis Colon Rectum. 2000;43(5):662–8. Kouladouros K, Warkentin V, Kähler G. Transanal endoscopic microsurgical submucosal dissection: are there advantages over conventional ESD? Minim Invasive Ther Allied Technol. 2021. Kouladouros K, Baral J. Transanal endoscopic microsurgical submucosal dissection (TEM-ESD): a novel approach to the local treatment of early rectal cancer. Surg Oncol. 2021 Dec;39:101662. Takamaru H, Saito Y, Yamada M, Tsuruki ES, Kinjo Y, Otake Y, et al. Clinical impact of endoscopic clip closure of perforations during endoscopic submucosal dissection for colorectal tumors. Gastrointest Endosc. 2016 Sep;84(3):494–502.e1. Lee SP, Kim JH, Sung IK, Lee SY, Park HS, Shim CS, et al. Effect of submucosal fibrosis on endoscopic submucosal dissection of colorectal tumors: pathologic review of 173 cases. J Gastroenterol Hepatol. 2015 May;30(5):872–8. Kandiah K, Subramaniam S, Chedgy F, Thayalasekaran S, Venetz D, Aepli P, et al. A novel non-thermal resection tool in endoscopic management of scarred polyps. Endosc Int Open. 2019 Aug;07(08):E974–8. Kobayashi N, Yoshitake N, Hirahara Y, Konishi J, Saito Y, Matsuda T, et al. Matched case-control study comparing endoscopic submucosal dissection and endoscopic mucosal resection for colorectal tumors. J Gastroenterol Hepatol. 2012;27(4):728–33. Lee EJ, Lee JB, Lee SH, Kim DS, Lee DH, Lee DS, et al. Endoscopic submucosal dissection for colorectal tumors – 1,000 colorectal ESD cases: one specialized institute’s experiences. Surg Endosc. 2013;27(1):31–9. Saito Y, Kawano H, Takeuchi Y, Ohata K, Oka S, Hotta K, et al. Current status of colorectal endoscopic submucosal dissection in Japan and other Asian countries: progressing towards technical standardization. Dig Endosc. 2012 May;24(Suppl 1):67–72. Saito Y, Sakamoto T, Fukunaga S, Nakajima T, Kiriyama S, Kuriyama S, et al. Endoscopic submucosal dissection (ESD) for colorectal tumors. Dig Endosc. 2009 Jul;21(Suppl 1):S7. Article / Publication Details

First-Page Preview

Abstract of Small and Large Bowel: Research Article

Received: November 12, 2021
Accepted: February 14, 2022
Published online: February 24, 2022

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 0257-2753 (Print)
eISSN: 1421-9875 (Online)

For additional information: https://www.karger.com/DDI

Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

留言 (0)

沒有登入
gif