Log in to MyKarger to check if you already have access to this content.
Buy FullText & PDF Unlimited re-access via MyKarger Unrestricted printing, no saving restrictions for personal use read more
CHF 38.00 *
EUR 35.00 *
USD 39.00 *
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price. Rent/Cloud Rent for 48h to view Buy Cloud Access for unlimited viewing via different devices Synchronizing in the ReadCube Cloud Printing and saving restrictions apply Rental: USD 8.50* The final prices may differ from the prices shown due to specifics of VAT rules.
Article / Publication Details AbstractIntroduction The drain amylase concentration (dAmy-C) is a useful marker for predicting pancreatic fistula after gastric cancer surgery. However, dAmy-C might be reduced in cases of high drainage volume. Therefore, we hypothesized that we could accurately assess the amount of amylase leaked from the pancreas by multiplying dAmy-C by the daily drainage volume. In this study, we investigated the clinical utility of the amount of drain amylase (A-dAmy: concentration × volume) for predicting pancreatic fistula. And, we investigated the clinical utility of the combination of dAmy-C and A-dAmy for predicting pancreatic fistula. Methods We investigated patients who underwent gastrectomy for gastric cancer at Yodogawa Christian Hospital between 2012 and 2020. The optimal cut-off levels of dAmy-C and A-dAmy on postoperative day 1 for predicting Clavien-Dindo grade II or higher pancreatic fistula were calculated using receiver operating characteristic (ROC) curves. And, we calculate the positive predictive value and negative predictive value for predicting pancreatic fistula using these cut-off levels. Results A total of 448 patients were eligible for analysis. Twenty-two patients experienced Clavien-Dindo grade II or higher pancreatic fistula. ROC curves identified 1,615 IU/L as the optimal cut-off level of dAmy-C predicting pancreatic fistula. When the simple cut-off level of dAmy-C was 1,600 IU/L, the positive predictive value for was 22.8% and the negative predictive value was 99.7%. ROC curves identified 177.52 IU as the optimal cut-off level of A-dAmy predicting pancreatic fistula. When the simple cut-off level of A-dAmy was 177 IU, the positive predictive value was 21.2% and the negative predictive value was 99.7%. Using these two cut-off levels together, the positive predictive value was 34.4% and the negative predictive value was 99.7%. Conclusion A-dAmy could predict and exclude pancreatic fistula after gastrectomy as with dAmy-C. The combination of dAmy-C and A-dAmy predict pancreatic fistula more accurately than dAmy-C alone.
S. Karger AG, Basel
Article / Publication Details Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
留言 (0)