Prognostic Utility of the Ki-67 Labeling Index in Follicular Thyroid Tumors: a 20-Year Experience from a Tertiary Thyroid Center

Lloyd RV, Osamura RY, Klöppel G, Rosai J, International Agency for Research on Cancer (2017) WHO classification of tumours of endocrine organs, 4th edition. International Agency for Research on Cancer, Lyon

Amin MB, American Joint Committee on Cancer, American Cancer Society (2017) AJCC cancer staging manual, Eight edition / editor-in-chief, Mahul B. Amin, MD, FCAP ; editors, Stephen B. Edge, MD, FACS [and 16 others] ; Donna M. Gress, RHIT, CTR-Technical editor ; Laura R. Meyer, CAPM-Managing editor. American Joint Committee on Cancer, Springer, Chicago IL

Werner TA, Dizdar L, Nolten I, Riemer JC, Mersch S, Schütte SC, Driemel C, Verde PE, Raba K, Topp SA, Schott M, Knoefel WT, Krieg A (2017) Survivin and XIAP - two potential biological targets in follicular thyroid carcinoma. Sci Rep 7:11383. https://doi.org/10.1038/s41598-017-11426-3

CAS  Article  PubMed  PubMed Central  Google Scholar 

Wu J, Zhang Y, Cheng R, Gong W, Ding T, Zhai Q, Wang Y, Meng B, Sun B (2019) Expression of epithelial-mesenchymal transition regulators TWIST, SLUG and SNAIL in follicular thyroid tumours may relate to widely invasive, poorly differentiated and distant metastasis. Histopathology 74:780–791. https://doi.org/10.1111/his.13778

Article  PubMed  Google Scholar 

Nicolson NG, Paulsson JO, Juhlin CC, Carling T, Korah R (2020) Transcription Factor Profiling Identifies Spatially Heterogenous Mediators of Follicular Thyroid Cancer Invasion. Endocr Pathol 31:367–376. https://doi.org/10.1007/s12022-020-09651-0

CAS  Article  PubMed  PubMed Central  Google Scholar 

Orlandi F, Saggiorato E, Pivano G, Puligheddu B, Termine A, Cappia S, De Giuli P, Angeli A (1998) Galectin-3 is a presurgical marker of human thyroid carcinoma. Cancer Res 58:3015–3020

CAS  PubMed  Google Scholar 

Xu XC, el-Naggar AK, Lotan R (1995) Differential expression of galectin-1 and galectin-3 in thyroid tumors. Potential diagnostic implications. Am J Pathol 147:815–822

CAS  PubMed  Google Scholar 

Lloyd RV, Carney JA, Ferreiro JA, Jin L, Thompson GB, Van Heerden JA, Grant CS, Wollan PC (1995) Immunohistochemical Analysis of the Cell Cycle-Associated Antigens Ki-67 and Retinoblastoma Protein in Parathyroid Carcinomas and Adenomas. Endocr Pathol 6:279–287. https://doi.org/10.1007/BF02738728

Article  PubMed  Google Scholar 

Juhlin CC, Erickson LA (2021) Genomics and Epigenomics in Parathyroid Neoplasia: from Bench to Surgical Pathology Practice. Endocr Pathol 32:17–34. https://doi.org/10.1007/s12022-020-09656-9

Article  PubMed  Google Scholar 

Pennanen M, Heiskanen I, Sane T, Remes S, Mustonen H, Haglund C, Arola J (2015) Helsinki score-a novel model for prediction of metastases in adrenocortical carcinomas. Hum Pathol 46:404–410. https://doi.org/10.1016/j.humpath.2014.11.015

Article  PubMed  Google Scholar 

Juhlin CC, Bertherat J, Giordano TJ, Hammer GD, Sasano H, Mete O (2021) What Did We Learn from the Molecular Biology of Adrenal Cortical Neoplasia? From Histopathology to Translational Genomics. Endocr Pathol 32:102–133. https://doi.org/10.1007/s12022-021-09667-0

CAS  Article  PubMed  Google Scholar 

Kimura N, Takayanagi R, Takizawa N, Itagaki E, Katabami T, Kakoi N, Rakugi H, Ikeda Y, Tanabe A, Nigawara T, Ito S, Kimura I, Naruse M, Phaeochromocytoma Study Group in Japan (2014) Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma. Endocr Relat Cancer 21:405–414. https://doi.org/10.1530/ERC-13-0494

Article  Google Scholar 

Juhlin CC (2021) Challenges in Paragangliomas and Pheochromocytomas: from Histology to Molecular Immunohistochemistry. Endocr Pathol 32:228–244. https://doi.org/10.1007/s12022-021-09675-0

Article  PubMed  PubMed Central  Google Scholar 

Kakudo K, Wakasa T, Ohta Y, Yane K, Ito Y, Yamashita H (2015) Prognostic classification of thyroid follicular cell tumors using Ki-67 labeling index: risk stratification of thyroid follicular cell carcinomas. Endocr J 62:1–12. https://doi.org/10.1507/endocrj.EJ14-0293

Article  PubMed  Google Scholar 

Ito Y, Hirokawa M, Miyauchi A, Masuoka H, Yabuta T, Fukushima M, Kihara M, Higashiyama T, Kobayashi K, Miya A (2016) Prognostic impact of Ki-67 labeling index in minimally invasive follicular thyroid carcinoma. Endocr J 63:913–917. https://doi.org/10.1507/endocrj.EJ16-0277

CAS  Article  PubMed  Google Scholar 

Katoh R, Bray CE, Suzuki K, Komiyama A, Hemmi A, Kawaoi A, Oyama T, Sugai T, Sasou S (1995) Growth activity in hyperplastic and neoplastic human thyroid determined by an immunohistochemical staining procedure using monoclonal antibody MIB-1. Hum Pathol 26:139–146. https://doi.org/10.1016/0046-8177(95)90029-2

CAS  Article  PubMed  Google Scholar 

Erickson LA, Jin L, Wollan PC, Thompson GB, van Heerden J, Lloyd RV (1998) Expression of p27kip1 and Ki-67 in benign and malignant thyroid tumors. Mod Pathol 11:169–174

CAS  PubMed  Google Scholar 

Tallini G, Garcia-Rostan G, Herrero A, Zelterman D, Viale G, Bosari S, Carcangiu ML (1999) Downregulation of p27KIP1 and Ki67/Mib1 labeling index support the classification of thyroid carcinoma into prognostically relevant categories. Am J Surg Pathol 23:678–685. https://doi.org/10.1097/00000478-199906000-00007

CAS  Article  PubMed  Google Scholar 

Rickert D, Mittermayer C, Lindenfelser R, Biesterfeld S (2000) MIB-1 immunohistometry of follicular adenoma and follicular carcinoma of the thyroid gland. Anal Quant Cytol Histol 22:229–234

CAS  PubMed  Google Scholar 

Ludvíková M, Holubec L, Ryska A, Topolcan O (2005) Proliferative markers in diagnosis of thyroid tumors: a comparative study of MIB-1 and topoisomerase II-a immunostaining. Anticancer Res 25:1835–1840

PubMed  Google Scholar 

Sofiadis A, Tani E, Foukakis T, Kjellman P, Skoog L, Höög A, Wallin G, Zedenius J, Larsson C (2009) Diagnostic and prognostic potential of MIB-1 proliferation index in thyroid fine needle aspiration biopsy. Int J Oncol 35:369–374

CAS  PubMed  Google Scholar 

Kjellman P, Wallin G, Höög A, Auer G, Larsson C, Zedenius J (2003) MIB-1 index in thyroid tumors: a predictor of the clinical course in papillary thyroid carcinoma. Thyroid 13:371–380. https://doi.org/10.1089/105072503321669866

Article  PubMed  Google Scholar 

Lindfors H, Ihre Lundgren C, Zedenius J, Juhlin CC, Shabo I (2021) The Clinical Significance of Lymph Node Ratio and Ki-67 Expression in Papillary Thyroid Cancer. World J Surg 45:2155–2164. https://doi.org/10.1007/s00268-021-06070-y

Article  PubMed  PubMed Central  Google Scholar 

Mu N, Juhlin CC, Tani E, Sofiadis A, Reihnér E, Zedenius J, Larsson C, Nilsson I-L (2018) High Ki-67 index in fine needle aspiration cytology of follicular thyroid tumors is associated with increased risk of carcinoma. Endocrine 61:293–302. https://doi.org/10.1007/s12020-018-1627-z

CAS  Article  PubMed  PubMed Central  Google Scholar 

Rindi G, Klöppel G, Alhman H, Caplin M, Couvelard A, de Herder WW, Erikssson B, Falchetti A, Falconi M, Komminoth P, Körner M, Lopes JM, McNicol A-M, Nilsson O, Perren A, Scarpa A, Scoazec J-Y, Wiedenmann B, all other Frascati Consensus Conference participants, European Neuroendocrine Tumor Society (ENETS) (2006) TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system. Virchows Arch 449:395–401. https://doi.org/10.1007/s00428-006-0250-1

Article  Google Scholar 

Hysek M, Paulsson JO, Jatta K, Shabo I, Stenman A, Höög A, Larsson C, Zedenius J, Juhlin CC (2019) Clinical Routine TERT Promoter Mutational Screening of Follicular Thyroid Tumors of Uncertain Malignant Potential (FT-UMPs): A Useful Predictor of Metastatic Disease. Cancers (Basel) 11. https://doi.org/10.3390/cancers11101443

Juhlin CC (2020) A Clinical Overview of Telomerase-Associated Aberrancies in Follicular Thyroid Tumors as Diagnostic and Prognostic Markers: Tert Alert! Scand J Surg 109:187–192. https://doi.org/10.1177/1457496919850434

CAS  Article  PubMed  Google Scholar 

Liu T, Wang N, Cao J, Sofiadis A, Dinets A, Zedenius J, Larsson C, Xu D (2014) The age- and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomas. Oncogene 33:4978–4984. https://doi.org/10.1038/onc.2013.446

CAS  Article  PubMed  Google Scholar 

Paulsson JO, Mu N, Shabo I, Wang N, Zedenius J, Larsson C, Juhlin CC (2018) TERT aberrancies: a screening tool for malignancy in follicular thyroid tumours. Endocr Relat Cancer 25:723–733. https://doi.org/10.1530/ERC-18-0050

CAS  Article  PubMed  Google Scholar 

American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper DS, Doherty GM, Haugen BR, Hauger BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM (2009) Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 19:1167–1214. https://doi.org/10.1089/thy.2009.0110

Nicolson NG, Murtha TD, Dong W, Paulsson JO, Choi J, Barbieri AL, Brown TC, Kunstman JW, Larsson C, Prasad ML, Korah R, Lifton RP, Juhlin CC, Carling T (2018) Comprehensive Genetic Analysis of Follicular Thyroid Carcinoma Predicts Prognosis Independent of Histology. J Clin Endocrinol Metab 103:2640–2650. https://doi.org/10.1210/jc.2018-00277

Article  PubMed  Google Scholar 

Bournaud C, Descotes F, Decaussin-Petrucci M, Berthiller J, de la Fouchardière C, Giraudet A-L, Bertholon-Gregoire M, Robinson P, Lifante J-C, Lopez J, Borson-Chazot F (2019) TERT promoter mutations identify a high-risk group in metastasis-free advanced thyroid carcinoma. Eur J Cancer 108:41–49. https://doi.org/10.1016/j.ejca.2018.12.003

CAS  Article  PubMed  Google Scholar 

Landa I, Ganly I, Chan TA, Mitsutake N, Matsuse M, Ibrahimpasic T, Ghossein RA, Fagin JA (2013) Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease. J Clin Endocrinol Metab 98:E1562-1566. https://doi.org/10.1210/jc.2013-2383

CAS  Article  PubMed  PubMed Central  Google Scholar 

Tanaka A, Matsuse M, Saenko V, Nakao T, Yamanouchi K, Sakimura C, Yano H, Nishihara E, Hirokawa M, Suzuki K, Miyauchi A, Eguchi S, Yoshiura K-I, Yamashita S, Nagayasu T, Mitsutake N (2019) TERT mRNA Expression as a Novel Prognostic Marker in Papillary Thyroid Carcinomas. Thyroid 29:1105–1114. https://doi.org/10.1089/thy.2018.0695

CAS  Article  PubMed  Google Scholar 

Hellgren LS, Olsson A, Kaufeldt A, Paulsson JO, Hysek M, Stenman A, Zedenius J, Larsson C, Höög A, Juhlin CC (2021) Nuclear-specific accumulation of telomerase reverse transcriptase (TERT) mRNA in TERT promoter mutated follicular thyroid tumours visualised by in situ hybridisation: a possible clinical screening tool? J Clin Pathol jclinpath-2021–207631. https://doi.org/10.1136/jclinpath-2021-207631

Hysek M, Jatta K, Hellgren LS, Stenman A, Larsson C, Zedenius J, Juhlin CC (2021) Spatial Distribution Patterns of Clinically Relevant TERT Promoter Mutations in Follicular Thyroid Tumors of Uncertain Malignant Potential: Advantages of the Digital Droplet PCR Technique. J Mol Diagn 23:212–222. https://doi.org/10.1016/j.jmoldx.2020.10.016

CAS  Article  PubMed  Google Scholar 

Nikiforova MN, Wald AI, Roy S, Durso MB, Nikiforov YE (2013) Targeted next-generation sequencing panel (ThyroSeq) for detection of mutations in thyroid cancer. J Clin Endocrinol Metab 98:E1852-1860. https://doi.org/10.1210/jc.2013-2292

CAS  Article  PubMed  PubMed Central  Google Scholar 

Duick DS, Klopper JP, Diggans JC, Friedman L, Kennedy GC, Lanman RB, McIver B (2012) The impact of benign gene expression classifier test results on the endocrinologist-patient decision to operate on patients with thyroid nodules with indeterminate fine-needle aspiration cytopathology. Thyroid 22:996–1001. https://doi.org/10.1089/thy.2012.0180

CAS  Article  PubMed  PubMed Central  Google Scholar 

Baloch Z, Mete O, Asa SL (2018) Immunohistochemical Biomarkers in Thyroid Pathology. Endocr Pathol 29:91–112. https://doi.org/10.1007/s12022-018-9532-9

CAS  Article  PubMed  Google Scholar 

Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho Simões M, Tallini G, Mete O (2022) Overview of the 2022 WHO Classification of Thyroid Neoplasms. Endocrine Pathology. https://doi.org/10.1007/s12022-022-09707-3

Article  PubMed 

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