In recent years, reconstruction of structures in the posteromedial and posterolateral corners of the knee has increased in popularity. While these procedures produce good objective and subjective patient outcomes, the increasing incidence of these procedures also results in a higher rate of complications. There is currently a paucity of literature on the avoidance, identification, and management of complications that can occur in the setting of medial and lateral knee surgery. Common complications of surgery of the lateral knee include common peroneal nerve injury, equinus deformity, fibular head fracture, difficult graft passage, incorrect tensioning of the graft, graft amputation, incorrect tunnel placement, recurrent instability, and arthrofibrosis. Common complications of medial sided surgery include heterotopic ossification, incorrect tunnel placement, tunnel convergence, incorrect graft length, incorrect graft tensioning, hardware irritation, recurrent instability, and arthrofibrosis. The aim of this article is to discuss ways to avoid these complications, and how to identify and manage them if they occur.