Pickard JM, Zeng MY, Caruso R, Nunez G (2017) Gut microbiota: role in pathogen colonization, immune responses, and inflammatory disease. Immunol Rev 279(1):70–89
CAS PubMed PubMed Central Google Scholar
Bouskra D, Brezillon C, Berard M, Werts C, Varona R, Boneca IG, Eberl G (2008) Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature 456(7221):507–510
CAS PubMed PubMed Central Google Scholar
Yun Y, Srinivas G, Kuenzel S, Linnenbrink M, Alnahas S, Bruce KD, Steinhoff U, Baines JF, Schaible UE (2014) Environmentally determined differences in the murine lung microbiota and their relation to alveolar architecture. PLoS One 9(12):e113466
Cryan JF, Dinan TG (2012) Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 13(10):701–712
Hilty M, Burke C, Pedro H, Cardenas P, Bush A, Bossley C, Davies J, Ervine A, Poulter L, Pachter L, Moffatt MF, Cookson WO (2010) Disordered microbial communities in asthmatic airways. PLoS One 5(1):e8578
Erb-Downward JR, Thompson DL, Han MK, Freeman CM, McCloskey L, Schmidt LA, Young VB, Toews GB, Curtis JL, Sundaram B, Martinez FJ, Huffnagle GB (2011) Analysis of the lung microbiome in the healthy smoker and in COPD. PLoS One 6(2):e16384
Cox MJ, Allgaier M, Taylor B, Baek MS, Huang YJ, Daly RA, Karaoz U, Andersen GL, Brown R, Fujimura KE, Wu B, Tran D, Koff J, Kleinhenz ME, Nielson D, Brodie EL, Lynch SV (2010) Airway microbiota and pathogen abundance in age-stratified cystic fibrosis patients. PLoS One 5(6):e11044
Demoruelle MK, Norris J, Holers V, Harris J, Deane K (2014) The lung microbiome differs in asymptomatic subjects at elevated risk of future rheumatoid arthritis compared with healthy control subjects. Ann Am Thorac Soc 11:S74
Veldhoen M (2017) Interleukin 17 is a chief orchestrator of immunity. Nat Immunol 18(6):612–621
Effros RM (2006) Anatomy, development, and physiology of the lungs. GI Motility
Gusareva ES, Acerbi E, Lau KJX, Luhung I, Premkrishnan BNV, Kolundzija S, Purbojati RW, Wong A, Houghton JNI, Miller D, Gaultier NE, Heinle CE, Clare ME, Vettath VK, Kee C, Lim SBY, Chenard C, Phung WJ, Kushwaha KK, Nee AP, Putra A, Panicker D, Yanqing K, Hwee YZ, Lohar SR, Kuwata M, Kim HL, Yang L, Uchida A, Drautz-Moses DI, Junqueira ACM, Schuster SC (2019) Microbial communities in the tropical air ecosystem follow a precise diel cycle. Proc Natl Acad Sci U S A 116(46):23299–23308
CAS PubMed PubMed Central Google Scholar
Dickson RP, Erb-Downward JR, Martinez FJ, Huffnagle GB (2016) The Microbiome and the Respiratory Tract. Annu Rev Physiol 78:481–504
Man WH, de Steenhuijsen Piters WA, Bogaert D (2017) The microbiota of the respiratory tract: gatekeeper to respiratory health. Nat Rev Micro 15(5):259–270
Zhou Y, Mihindukulasuriya KA, Gao H, La Rosa PS, Wylie KM, Martin JC, Kota K, Shannon WD, Mitreva M, Sodergren E, Weinstock GM (2014) Exploration of bacterial community classes in major human habitats. Genome Biol 15(5):R66
PubMed PubMed Central Google Scholar
Edouard S, Million M, Bachar D, Dubourg G, Michelle C, Ninove L, Charrel R, Raoult D (2018) The nasopharyngeal microbiota in patients with viral respiratory tract infections is enriched in bacterial pathogens. Eur J Clin Microbiol Infect Dis 37(9):1725–1733
Le Bars P, Matamoros S, Montassier E, Le Vacon F, Potel G, Soueidan A, Jordana F, de La Cochetiere MF (2017) The oral cavity microbiota: between health, oral disease, and cancers of the aerodigestive tract. Can J Microbiol 63(6):475–492
Charlson ES, Chen J, Custers-Allen R, Bittinger K, Li H, Sinha R, Hwang J, Bushman FD, Collman RG (2010) Disordered microbial communities in the upper respiratory tract of cigarette smokers. PLoS One 5(12):e15216
Pettigrew MM, Laufer AS, Gent JF, Kong Y, Fennie KP, Metlay JP (2012) Upper respiratory tract microbial communities, acute otitis media pathogens, and antibiotic use in healthy and sick children. Appl Environ Microbiol 78(17):6262–6270
CAS PubMed PubMed Central Google Scholar
Teo SM, Mok D, Pham K, Kusel M, Serralha M, Troy N, Holt BJ, Hales BJ, Walker ML, Hollams E, Bochkov YA, Grindle K, Johnston SL, Gern JE, Sly PD, Holt PG, Holt KE, Inouye M (2015) The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development. Cell Host Microbe 17(5):704–715
CAS PubMed PubMed Central Google Scholar
LeVine AM, Whitsett JA, Gwozdz JA, Richardson TR, Fisher JH, Burhans MS, Korfhagen TR (2000) Distinct effects of surfactant protein A or D deficiency during bacterial infection on the lung. J Immunol 165(7):3934–3940
Bassis CM, Erb-Downward JR, Dickson RP, Freeman CM, Schmidt TM, Young VB, Beck JM, Curtis JL, Huffnagle GB (2015) Analysis of the upper respiratory tract microbiotas as the source of the lung and gastric microbiotas in healthy individuals. MBio 6(2):e00037
Huffnagle GB, Dickson RP, Lukacs NW (2017) The respiratory tract microbiome and lung inflammation: a two-way street. Mucosal Immunol 10(2):299–306
Cameron SJS, Lewis KE, Huws SA, Hegarty MJ, Lewis PD, Pachebat JA, Mur LAJ (2017) A pilot study using metagenomic sequencing of the sputum microbiome suggests potential bacterial biomarkers for lung cancer. PLoS One 12(5):e0177062-e
Ren Y, Su H, She Y, Dai C, Xie D, Narrandes S, Huang S, Chen C, Xu W (2019) Whole genome sequencing revealed microbiome in lung adenocarcinomas presented as ground-glass nodules. Transl Lung Cancer Res 8(3):235–246
CAS PubMed PubMed Central Google Scholar
Jin C, Lagoudas GK, Zhao C, Bullman S, Bhutkar A, Hu B, Ameh S, Sandel D, Liang XS, Mazzilli S, Whary MT, Meyerson M, Germain R, Blainey PC, Fox JG, Jacks T (2019) Commensal microbiota promote lung cancer development via gammadelta T cells. Cell 176(5):998-1013.e16
CAS PubMed PubMed Central Google Scholar
Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT (2005) Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6(11):1123–1132
Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C (2005) A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6(11):1133–1141
CAS PubMed PubMed Central Google Scholar
McGeachy MJ, Cua DJ, Gaffen SL (2019) The IL-17 family of cytokines in health and disease. Immunity 50(4):892–906
CAS PubMed PubMed Central Google Scholar
Molet S, Hamid Q, Davoine F, Nutku E, Taha R, Page N, Olivenstein R, Elias J, Chakir J (2001) IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol 108(3):430–438
Halwani R, Sultana A, Vazquez-Tello A, Jamhawi A, Al-Masri AA, Al-Muhsen S (2017) Th-17 regulatory cytokines IL-21, IL-23, and IL-6 enhance neutrophil production of IL-17 cytokines during asthma. J Asthma 54(9):893–904
Yang D, Chen X, Wang J, Lou Q, Lou Y, Li L, Wang H, Chen J, Wu M, Song X, Qian Y (2019) Dysregulated lung commensal bacteria drive interleukin-17B production to promote pulmonary fibrosis through their outer membrane vesicles. Immunity 50(3):692-706.e7
Wilson MS, Madala SK, Ramalingam TR, Gochuico BR, Rosas IO, Cheever AW, Wynn TA (2010) Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. J Exp Med 207(3):535–552
CAS PubMed PubMed Central Google Scholar
Paats MS, Bergen IM, Hoogsteden HC, van der Eerden MM, Hendriks RW (2012) Systemic CD4+ and CD8+ T-cell cytokine profiles correlate with GOLD stage in stable COPD. Eur Respir J 40(2):330–337
Di Stefano A, Caramori G, Gnemmi I, Contoli M, Vicari C, Capelli A, Magno F, D’Anna SE, Zanini A, Brun P, Casolari P, Chung KF, Barnes PJ, Papi A, Adcock I, Balbi B (2009) T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients. Clin Exp Immunol 157(2):316–324
PubMed PubMed Central Google Scholar
Eustace A, Smyth LJC, Mitchell L, Williamson K, Plumb J, Singh D (2011) Identification of cells expressing IL-17A and IL-17F in the lungs of patients with COPD. Chest 139(5):1089–1100
Vargas-Rojas MI, Ramírez-Venegas A, Limón-Camacho L, Ochoa L, Hernández-Zenteno R, Sansores RH (2011) Increase of Th17 cells in peripheral blood of patients with chronic obstructive pulmonary disease. Respir Med 105(11):1648–1654
Zhang J, Chu S, Zhong X, Lao Q, He Z, Liang Y (2013) Increased expression of CD4+IL-17+ cells in the lung tissue of patients with stable chronic obstructive pulmonary disease (COPD) and smokers. Int Immunopharmacol 15(1):58–66
Xu W, Li R, Sun Y (2019) Increased IFN-γ-producing Th17/Th1 cells and their association with lung function and current smoking status in patients with chronic obstructive pulmonary disease. BMC Pulm Med 19(1):137
PubMed PubMed Central Google Scholar
Tan H-L, Regamey N, Brown S, Bush A, Lloyd CM, Davies JC (2011) The Th17 pathway in cystic fibrosis lung disease. Am J Respir Crit Care Med 184(2):252–258
Brodlie M, McKean MC, Johnson GE, Anderson AE, Hilkens CM, Fisher AJ, Corris PA, Lordan JL, Ward C (2011) Raised interleukin-17 is immunolocalised to neutrophils in cystic fibrosis lung disease. The Eur Respir J 37(6):1378–1385
Chen ACH, Martin ML, Lourie R, Rogers GB, Burr LD, Hasnain SZ, Bowler SD, McGuckin MA, Serisier DJ (2015) Adult non-cystic fibrosis bronchiectasis is characterised by airway luminal Th17 pathway activation. PLoS One 10(3):e0119325-e
McInnes IB, Schett G (2011) The pathogenesis of rheumatoid arthritis. N Engl J Med 365(23):2205–2219
CAS PubMed PubMed Central Google Scholar
Gaffen SL (2009) The role of interleukin-17 in the pathogenesis of rheumatoid arthritis. Curr Rheumatol Rep 11(5):365–370
CAS PubMed PubMed Central Google Scholar
Van Hamburg JP, Asmawidjaja PS, Davelaar N, Mus AM, Colin EM, Hazes JM, Dolhain RJ, Lubberts E (2011) Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production. Arthritis Rheum 63(1):73–83
Chalan P, Kroesen B-J, van der Geest KSM, Huitema MG, Abdulahad WH, Bijzet J, Brouwer E, Boots AMH (2013) Circulating CD4+CD161+ T lymphocytes are increased in seropositive arthralgia patients but decreased in patients with newly diagnosed rheumatoid arthritis. PLoS One 8(11):e79370
Kouri V-P, Olkkonen J, Ainola M, Li T-F, Björkman L, Konttinen YT, Mandelin J (2013) Neutrophils produce interleukin-17B in rheumatoid synovial tissue. Rheumatology 53(1):39–47
Liu D, Cao T, Wang N, Liu C, Ma N, Tu R, Min X (2016) IL-25 attenuates rheumatoid arthritis through suppression of Th17 immune responses in an IL-13-dependent manner. Sci Rep 6(1):36002
CAS PubMed PubMed Central Google Scholar
Akitsu A, Ishigame H, Kakuta S, Chung SH, Ikeda S, Shimizu K, Kubo S, Liu Y, Umemura M, Matsuzaki G, Yoshikai Y, Saijo S, Iwakura Y (2015) IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vgamma6(+)gammadelta T cells. Nat Commun 6:7464
留言 (0)