Deconvolution of the epigenetic age discloses distinct inter-personal variability in epigenetic aging patterns

Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):R115.

PubMed  PubMed Central  Google Scholar 

Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY). 2018;10(4):573–91.

Google Scholar 

Lu AT, Quach A, Wilson JG, Reiner AP, Aviv A, Raj K, et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging (Albany NY). 2019;11(2):303–27.

CAS  Google Scholar 

McCrory C, Fiorito G, Hernandez B, Polidoro S, O’Halloran AM, Hever A, et al. GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality. J Gerontol Ser A. 2020;76(5):741–9.

Google Scholar 

Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda SV, et al. Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell. 2013;49(2):359–67.

CAS  PubMed  Google Scholar 

Horvath S, Raj K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat Rev Genet. 2018;19(6):371–84.

CAS  PubMed  Google Scholar 

Chen BH, Marioni RE, Colicino E, Peters MJ, Ward-Caviness CK, Tsai PC, et al. DNA methylation-based measures of biological age: Meta-analysis predicting time to death. Aging (Albany NY). 2016;8(9):1844–65.

CAS  Google Scholar 

Horvath S, Gurven M, Levine ME, Trumble BC, Kaplan H, Allayee H, et al. An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease. Genome Biol. 2016;17:171.

PubMed  PubMed Central  Google Scholar 

Zhang Y, Wilson R, Heiss J, Breitling LP, Saum KU, Schöttker B, et al. DNA methylation signatures in peripheral blood strongly predict all-cause mortality. Nat Commun. 2017;8:14617.

CAS  PubMed  PubMed Central  Google Scholar 

Levine ME, Hosgood HD, Chen B, Absher D, Assimes T, Horvath S. DNA methylation age of blood predicts future onset of lung cancer in the women’s health initiative. Aging (Albany NY). 2015;7(9):690–700.

CAS  Google Scholar 

Ambatipudi S, Horvath S, Perrier F, Cuenin C, Hernandez-Vargas H, Le Calvez-Kelm F, et al. DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility. Eur J Cancer. 2017;75:299–307.

CAS  PubMed  PubMed Central  Google Scholar 

Roetker NS, Pankow JS, Bressler J, Morrison AC, Boerwinkle E. Prospective study of epigenetic age acceleration and incidence of cardiovascular disease outcomes in the ARIC Study (atherosclerosis risk in communities). Circ Genomic Precis Med. 2018;11(3):e001937.

Google Scholar 

Liu Z, Leung D, Thrush K, Zhao W, Ratliff S, Tanaka T, et al. Underlying features of epigenetic aging clocks in vivo and in vitro. Aging Cell. 2020;19(10):e13229.

CAS  PubMed  PubMed Central  Google Scholar 

Fahy GM, Brooke RT, Watson JP, Good Z, Vasanawala SS, Maecker H, et al. Reversal of epigenetic aging and immunosenescent trends in humans. Aging Cell. 2019;18(6):e13028.

CAS  PubMed  PubMed Central  Google Scholar 

Hahn O, Grönke S, Stubbs TM, Ficz G, Hendrich O, Krueger F, et al. Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism. Genome Biol. 2017;18(1):56.

PubMed  PubMed Central  Google Scholar 

Yusipov I, Bacalini MG, Kalyakulina A, Krivonosov M, Pirazzini C, Gensous N, et al. Age-related DNA methylation changes are sex-specific: a comprehensive assessment. Aging (Albany NY). 2020;12(23):24057–80.

CAS  Google Scholar 

Irvin MR, Aslibekyan S, Do A, Zhi D, Hidalgo B, Claas SA, et al. Metabolic and inflammatory biomarkers are associated with epigenetic aging acceleration estimates in the GOLDN study. Clin Epigenet. 2018;18(10):56.

Google Scholar 

Vidaki A, Ballard D, Aliferi A, Miller TH, Barron LP, Syndercombe CD. DNA methylation-based forensic age prediction using artificial neural networks and next generation sequencing. Forensic Sci Int Genet. 2017;28:225–36.

CAS  PubMed  PubMed Central  Google Scholar 

Sanchez-Martin P, Lahuerta M, Viana R, Knecht E, Sanz P. Regulation of the autophagic PI3KC3 complex by laforin/malin E3-ubiquitin ligase, two proteins involved in Lafora disease. Biochim Biophys Acta Mol Cell Res. 2020;1867(2):118613.

CAS  PubMed  Google Scholar 

Tagliabracci VS, Girard JM, Segvich D, Meyer C, Turnbull J, Zhao X, et al. Abnormal metabolism of glycogen phosphate as a cause for Lafora disease. J Biol Chem. 2008;283(49):33816–25.

CAS  PubMed  PubMed Central  Google Scholar 

Nitschke F, Sullivan MA, Wang P, Zhao X, Chown EE, Perri AM, et al. Abnormal glycogen chain length pattern, not hyperphosphorylation, is critical in Lafora disease. EMBO Mol Med. 2017;9(7):906–17.

CAS  PubMed  PubMed Central  Google Scholar 

Roach PJ. Glycogen phosphorylation and Lafora disease. Mol Aspects Med. 2015;46:78–84.

CAS  PubMed  PubMed Central  Google Scholar 

Cavanagh JB. Corpora-amylacea and the family of polyglucosan diseases. Brain Res Rev. 1999;29:265–95.

CAS  PubMed  Google Scholar 

Cisse S, Perry G, Lacoste-Royal G, Cabana T, Gauvreau D. Immunochemical identification of ubiquitin and heat-shock proteins in corpora amylacea from normal aged and Alzheimer’s disease brains. Acta Neuropathol. 1993;85(3):233–40.

CAS  PubMed  Google Scholar 

Sinadinos C, Valles-Ortega J, Boulan L, Solsona E, Tevy MF, Marquez M, et al. Neuronal glycogen synthesis contributes to physiological aging. Aging Cell. 2014;13(5):935–45.

CAS  PubMed  PubMed Central  Google Scholar 

Sun RC, Dukhande VV, Zhou Z, Young LEA, Emanuelle S, Brainson CF, et al. Nuclear glycogenolysis modulates histone acetylation in human non-small cell lung cancers. Cell Metab. 2019;30(5):903–16.

CAS  PubMed  PubMed Central  Google Scholar 

Bilanges B, Posor Y, Vanhaesebroeck B. PI3K isoforms in cell signalling and vesicle trafficking. Nat Rev Mol Cell Biol. 2019;20:515–34.

CAS  PubMed  Google Scholar 

Sengupta S, Badhwar I, Upadhyay M, Singh S, Ganesh S. Malin and laforin are essential components of a protein complex that protects cells from thermal stress. J Cell Sci. 2011;124(13):2277–86.

CAS  PubMed  Google Scholar 

Wagner L, Oliyarnyk O, Gartner W, Nowotny P, Groeger M, Kaserer K, et al. Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein. J Biol Chem. 2000;275(32):24740–51.

CAS  PubMed  Google Scholar 

Yang SY, Lee JJ, Lee JH, Lee K, Oh SH, Lim YM, et al. Secretagogin affects insulin secretion in pancreatic β-cells by regulating actin dynamics and focal adhesion. Biochem J. 2016;473(12):1791–803.

CAS  PubMed  Google Scholar 

Sharma AK, Khandelwal R, Kumar MJM, Ram NS, Chidananda AH, Raj TA, et al. Secretagogin regulates insulin signaling by direct insulin binding. iScience. 2019;21:736–53.

CAS  PubMed  PubMed Central  Google Scholar 

Malenczyk K, Girach F, Szodorai E, Storm P, Segerstolpe Å, Tortoriello G, et al. A TRPV 1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover. EMBO J. 2017;36(14):2107–25.

CAS  PubMed  PubMed Central  Google Scholar 

Dong Y, Li Y, Liu R, Li Y, Zhang H, Liu H, et al. Secretagogin, a marker for neuroendocrine cells, is more sensitive and specific in large cell neuroendocrine carcinoma compared with the markers CD56, CgA. Syn and Napsin A Oncol Lett. 2020. https://doi.org/10.3892/ol.2020.11336.

Article  PubMed  Google Scholar 

Romanov RA, Alpár A, Zhang M, Zeisel A, Calas A, Landry M, et al. A secretagogin locus of the mammalian hypothalamus controls stress hormone release. EMBO J. 2015;34(1):36–54.

CAS  PubMed  Google Scholar 

Hevesi Z, Zelena D, Romanov RA, Hanics J, Ignácz A, Zambon A, et al. Secretagogin marks amygdaloid PKCδ interneurons and modulates NMDA receptor availability. Proc Natl Acad Sci U S A. 2021;118(7):e1921123118.

CAS  PubMed  PubMed Central  Google Scholar 

Schiavi A, Maglioni S, Palikaras K, Shaik A, Strappazzon F, Brinkmann V, et al. Iron-starvation-induced mitophagy mediates lifespan extension upon mitochondrial stress in C. elegans. Curr Biol. 2015;25(14):1810–22.

CAS  PubMed  Google Scholar 

Lynch DR, Farmer JM, Balcer LJ, Wilson RB. Friedreich ataxia: effects of genetic understanding on clinical evaluation and therapy. Arch Neurol. 2002;59:743–7.

PubMed  Google Scholar 

Campuzano V, Montermini L, Molto MD, Pianese L, Cossee M, Cavalcanti F, et al. Friedreich’s Ataxia: autosomal recessive disase caused by an intronic GAA triplet repeat expansion. Science (80-). 1996;271:1423–7.

CAS  Google Scholar 

Parkinson MH, Boesch S, Nachbauer W, Mariotti C, Giunti P. Clinical features of Friedreich’s ataxia: classical and atypical phenotypes. J Neurochem. 2013. https://doi.org/10.1111/jnc.12317.

Article  PubMed  Google Scholar 

Lee SS, Lee RYN, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet. 2003;33:40–8.

CAS  PubMed  Google Scholar 

Ventura N, Rea S, Henderson ST, Condo I, Johnson TE, Testi R. Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans. Aging Cell. 2005;4(2):109–12.

CAS  PubMed  Google Scholar 

Roshandel D, Chen Z, Canty AJ, Bull SB, Natarajan R, Paterson AD, et al. DNA methylation age calculators reveal association with diabetic neuropathy in type 1 diabetes. Clin Epigenetics. 2020;12(1):1–16.

Google Scholar 

Yang K, Shen J, Chen SW, Qin J, Zheng XY, Xie LP. Upregulation of PAWR by small activating RNAs induces cell apoptosis in human prostate cancer cells. Oncol Rep. 2016;35(4):2487–93.

CAS  PubMed  Google Scholar 

Song R, Li Y, Hao W, Yang L, Chen B, Zhao Y, et al. Circular RNA MTO1 inhibits gastric cancer progression by elevating PAWR via sponging miR-199a-3p. Cell Cycle. 2020;19(22):3127–39.

CAS  PubMed  PubMed Central 

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