Available online 8 March 2022, 101602

Formyl peptide receptor type 2 (FPR2) regulates the initiation and resolution phases of the inflammatory response. In the setting of heart injury and disease, dysregulated inflammation can potentiate maladaptive healing and pathological remodeling of the heart leading to cardiac dysfunction and failure. The potential to regulate and resolve adverse inflammation is postulated to improve outcome in the setting of heart disease. This review covers emerging concepts on the role of FPR2 in heart disease and strategies to activate pro-resolution processes to limit disease progression. We summarize key preclinical studies that support use of FPR2 agonists in heart disease. Finally, we briefly discuss the status of FPR2 agonists under evaluation in the clinic.

CC chemokine receptor 2

Damage associated molecular pattern

Formyl peptide receptor

FPR2, Formyl peptide receptor 2

Resolution

MI, Myocardial infarction

HF, Heart failure

© 2022 The Authors. Published by Elsevier Ltd.