aDepartments of Biochemistry and Medicine, Schulich School of Medicine and Dentistry

bRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London

cDepartment of Medicine, Queen's University, Kingston, Ontario, Canada

Correspondence to Robert A. Hegele, MD, FRCPC, FACP, Robarts Research Institute, Western University, 4288A-1151 Richmond Street North, London, Ontario N6A 5B7, Canada. Tel: +1 519 931 5271; fax: +1 519 931 5218; e-mail: [email protected]

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