aDepartment of Bioengineering, School of Engineering and Applied Science

bCardiovascular Institute, Department of Medicine, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Correspondence to Kiran Musunuru, MD, PhD, MPH, ML, University of Pennsylvania, 11-104 Smilow Center for Translational Research, 3400 Civic Center Boulevard, Bldg. 421, Philadelphia, PA 19104, USA. Tel: +1 215 573 4717; fax: +1 215 746-7415; e-mail: [email protected]