A Prospective, 3-year Longitudinal Study of Modic Changes of the Lumbar Spine in a Population-based Cohort: The Wakayama Spine Study

aDepartment of Orthopedic Surgery, Wakayama Medical University, Wakayama, Japan

bSpine Care Center, Wakayama Medical University Kihoku Hospital, Wakayama, Japan

cDepartment of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical and Research Center, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

dDepartment of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, China

eDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL

fDepartment of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

gDepartment of Orthopedic Surgery, The University of Tokyo, Bunkyoku, Tokyo, Japan

hDepartment of Orthopedic Surgery, Sumiya Orthopedic Hospital, Wakayama City, Wakayama, Japan.

Address correspondence and reprint requests to Masatoshi Teraguchi, MD, PhD, Department of Orthopedic Surgery, Wakayama Medical University Kihoku Hospital, 219 Myoji, Katsuragi town, Ito, Wakayama 649-7113, Japan; E-mail: [email protected]

Received 16 June, 2021

Revised 13 November, 2021

Accepted 17 November, 2021

The manuscript submitted does not contain information about medical device(s)/drug(s).

This study was supported by Grant-in-Aid funding from the Ministry of Health, Labour and Welfare 21FA0601, Scientific Research grants 22591639, 25462305, 16K10834, and Scientific Research grants 26462249, 21K09306, grants from the Japan Osteoporosis Society, a grant from JA Kyosai Research Institute, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research (KAKENHI) Research C (17K10937, 20K09509), and a grant from the Japanese Orthopedics and Traumatology Foundation, Inc (No. 287), Grant-in-Aid funding from the Ministry of Health, Labour and Welfare: H23-Choujyu-002, H25-Choujyu-007, and H25-Nanchitou (Men)-005, 19FA1401, and 19FA0701; Scientific Research grants B19H03895, B26293139, B23390172, and B20390182, and Challenging Exploratory Research grants 18K18447, 15K15219, and 24659317, Challenging Exploratory Research grants 24659666 and 21659349 and Young Scientists A18689031; Scientific Research grants B26293329, B23390357, and C20591737 and Challenging Exploratory Research grant 25670293, and by Collaborating Research with NSF from the Ministry of Education, Culture, Sports, Science and Technology in Japan 08033011-00262; grants from the Japan Agency for Medical Research and Development (17dk0110028h0001; 17gk0210007h0003, and 19gk0210018h0002); grants from the Japan Osteoporosis Society and Japan Osteoporosis Foundation 2015, the Japanese Society for Musculoskeletal Medicine (2015 and 2017), Mitsui Sumitomo Insurance Welfare Foundation (2016), and Japan Dairy Association (2017).

No relevant financial activities outside the submitted work.

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