Advances in Pharmacology and Pharmacy Vol. 10(1), pp. 69 - 75
DOI: 10.13189/app.2022.100106
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Jincy Thomas 1,*, A. Srinivas 2, Folitartha Roy 3
1 Department of Pharmacology, College of Pharmaceutical Sciences, Dayanada Sagar University, Bengaluru, Karnataka, India
2 Principal of Sree Dattha Institute of Pharmacy, Hyderabad, Telangana, India
3 Department of Pharmacology, Himalayan University, Jullang, Arunachal Pradesh, India

ABSTRACT

The current research has been performed to substantiate the traditional claim of the anti-diabetic activity of seeds of Datura Innoxia Mill. in rats. This plant contains scopolamine alkaloid, which has been reported to be used in operations as pre-anaesthesia, used in delivery, as well as in ocular surgeries and for travel sickness prophylaxis. Datura is a medicinal and hallucinogenic plant that is used everywhere in the globe. Datura is revered in Ayurveda because all parts of the plant have medicinal properties, including the roots, leaves, seeds, and flowers, and have been employed to treat a variety of ailments, including leprosy, rabies, and insanity. Withanolide has recently been found to have potent anti-tumor, anti-inflammatory, anti-bacterial, hepatoprotective, soporfic, cytotoxic, and immune suppressant properties. An alloxan-induced diabetes model in rats was used to test the anti-diabetic activity of an ethanolic extract of the seeds of Datura Innoxia Mill. (Family-Solanaceae). A comparison was made between both the animals treated with extract from seeds and animals treated with known drug for diabetes i.e.., glibenclamide. The extract dose was chosen based on acute oral toxicity tests conducted in accordance with OECD norms. The outcomes revealed the fact that ethanolic extract significantly reduced the glucose levels in blood. The findings supported the use of seeds extract in the treatment of diabetes.

KEYWORDS
Datura Innoxia Mill, Alloxan Monohydrate, Glibenclamide, Glucose, Glucometer

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Jincy Thomas , A. Srinivas , Folitartha Roy , "Evaluation of Anti Diabetic Activity of Ethanolic Seed Extract of Datura Innoxia Mill.," Advances in Pharmacology and Pharmacy, Vol. 10, No. 1, pp. 69 - 75, 2022. DOI: 10.13189/app.2022.100106.

(b). APA Format:
Jincy Thomas , A. Srinivas , Folitartha Roy (2022). Evaluation of Anti Diabetic Activity of Ethanolic Seed Extract of Datura Innoxia Mill.. Advances in Pharmacology and Pharmacy, 10(1), 69 - 75. DOI: 10.13189/app.2022.100106.