Elevated cystatin-C levels are associated with increased mortality in acute coronary syndrome patients: An HIJ-PROPER Sub-Analysis

Abstract

Background and aims: We investigated the association between serum cystatin-C levels and cardiovascular events in patients with acute coronary syndrome. Methods: Data of 1,100 patients from the prospective parent study were included. Patients hospitalized for acute coronary syndrome were divided into four groups based on quartiles (Q) of cystatin-C levels (mg/L) within 24-hours of admission: Q1, ≤0.82; Q2, 0.821.12. The primary endpoint of this study was all-cause mortality and secondary endpoint was composite of all-cause mortality, non-fatal myocardial infarction, non-fatal stroke, unstable angina pectoris, or ischemia-driven revascularization. Results: During a median observation period of 4.0 years, the primary endpoint was noted in 5, 12, 18, and 36 patients in Q1, Q2, Q3, and Q4, respectively, with corresponding incidence rates of 1.8%, 4.4%, 6.5%, and 13.5%, respectively (p

The Author(s). Published by S. Karger AG, Basel

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