Hu X.a· Hu K.b· Xu X.c· Zhang W.c· Xu F.c

Author affiliations

aClinical Laboratory of the First Affiliated Hospital of Nanchang University, Nanchang, China
b2019 Graduate Student of Urology, The First Clinical College of Nanchang University Medical College, Nanchang, China
cDepartment of Respiration, The First Affiliated Hospital of Nanchang University, Nanchang, China

Log in to MyKarger to check if you already have access to this content.

Buy FullText & PDF Unlimited re-access via MyKarger Unrestricted printing, no saving restrictions for personal use read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.

Save over 20% compared to the individual article price.

Learn more

Rent/Cloud Rent for 48h to view Buy Cloud Access for unlimited viewing via different devices Synchronizing in the ReadCube Cloud Printing and saving restrictions apply Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe Access to all articles of the subscribed year(s) guaranteed for 5 years Unlimited re-access via Subscriber Login or MyKarger Unrestricted printing, no saving restrictions for personal use read more

Subcription rates

Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview

Received: March 01, 2021
Accepted: November 08, 2021
Published online: January 31, 2022

Number of Print Pages: 11
Number of Figures: 6
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: https://www.karger.com/NIM

Abstract

Objective: In this study, we investigated that the effects and possible mechanisms of the α7 nAChR subunit duplicate form (CHRFAM7A) affected inflammation in the model of intracranial infection. Methods: Mice of the model group were injected (intracranial injection) with Staphylococcus aureus. Mouse microglial BV2 cell was exposed with 200 ng of LPS for 4 h. Results: CHRFAM7A mRNA expressions were reduced in patients with intracranial infection. CHRFAM7A mRNA and protein expressions were suppressed in mice with intracranial infection in a time-dependent manner. CHRFAM7A reduced inflammation in mice with intracranial infection. The inhibition of CHRFAM7A reduced inflammation in mice with intracranial infection. CHRFAM7A suppressed p38 MAPK in mice with intracranial infection. The inhibition of p38 MAPK shows the effects of CHRFAM7A in intracranial infection. Conclusion: Our data demonstrate that the expression of the CHRFAM7A was down-regulated in patients with intracranial infection and reduced inflammation in in vitro model by p38 MAPK, which suggests the potential role of CHRFAM7A as a diagnostic biomarker for intracranial infection.

© 2022 S. Karger AG, Basel

References Xie D, Xu W, Xian Y, Yuan X, Huang Z, You J, et al. Rare case of intracranial hemorrhage associated with seoul virus infection diagnosed by metagenomic next-generation sequencing. J Clin Lab Anal. 2021 Feb;35(2):e23616. Xiang L, Zhang T, Zhang B, Zhang C, Cui W, Yue W. Positive syphilis serology contributes to intracranial stenosis in ischemic stroke patients. Brain Behav. 2021;11(1):e01906. Xu Y, Wang RY, Zhao YH. Effects of perioperative comprehensive nursing based on risk prevention for patients with intracranial aneurysm. Int J Clin Pract. 2021;75(4):e13761. Offiah CE, Naseer A. Spectrum of imaging appearances of intracranial cryptococcal infection in HIV/AIDS patients in the anti-retroviral therapy era. Clin Radiol. 2016;71:9–17. Zhang S, Gao X, Xiao G, Lu C, Yao H, Fan H, et al. Intracranial subarachnoidal route of infection for investigating roles of Streptococcus suis biofilms in meningitis in a mouse infection model. J Vis Exp. 2018;(137):57658. Alawieh A, Chaudry MI, Turner RD, Turk AS, Spiotta AM. Infectious intracranial aneurysms: a systematic review of epidemiology, management, and outcomes. J Neurointerv Surg. 2018;10:708–16. Lei C, Ruan Y, Cai C, He B, Zhao D. Role of P38 mitogen-activated protein kinase on Cx43 phosphorylation in cerebral vasospasm after subarachnoid hemorrhage. Int J Neurosci. 2019;129:461–9. Wang BQ, Yang B, Yang HC, Wang JY, Hu S, Gao YS, et al. MicroRNA-499a decelerates glioma cell proliferation while accelerating apoptosis through the suppression of Notch1 and the MAPK signaling pathway. Brain Res Bull. 2018;142:96–106. Tang F, Wang H, Chen E, Bian E, Xu Y, Ji X, et al. LncRNA-ATB promotes TGF-β-induced glioma cells invasion through NF-κB and P38/MAPK pathway. J Cell Physiol. 2019;234:23302–14. Fan H, Gu R, Wei D. The α7 nAChR selective agonists as drug candidates for Alzheimer’s disease. Adv Exp Med Biol. 2015;827:353–65. Beinat C, Banister SD, Herrera M, Law V, Kassiou M. The therapeutic potential of α7 nicotinic acetylcholine receptor (α7 nAChR) agonists for the treatment of the cognitive deficits associated with schizophrenia. CNS Drugs. 2015;29:529–42. Treinin M, Papke RL, Nizri E, Ben-David Y, Mizrachi T, Brenner T. Role of the α7 nicotinic acetylcholine receptor and RIC-3 in the cholinergic anti-inflammatory pathway. Cent Nerv Syst Agents Med Chem. 2017;17:90–9. Zhang Q, Lu Y, Bian H, Guo L, Zhu H. Activation of the α7 nicotinic receptor promotes lipopolysaccharide-induced conversion of M1 microglia to M2. Am J Transl Res. 2017;9:971–85. Vonhoff CR, Wallis T, Jaeger M. Complications of elective intracranial pressure monitoring in adult hydrocephalus. J Clin Neurosci. 2020;79:67–70. Yu Y, Li HJ. Diagnostic and prognostic value of procalcitonin for early intracranial infection after craniotomy. Braz J Med Biol Res. 2017;50:e6021. Brown P, Fulks D. An unusual ischaemic presentation of thrombosed intracranial mycotic aneurysm with subsequent subarachnoid haemorrhage. BMJ Case Rep. 2020;13:e237044. Nagata E, Nishiyama T, Yamashita M, Ishigami T, Oho T. A primary canine and an impacted permanent canine with infection potentially induced an intracranial abscess. Aust Dent J. 2020;65:96–9. Nickerson JP, Richner B, Santy K, Lequin MH, Poretti A, Filippi CG, et al. Neuroimaging of pediatric intracranial infection – part 1: techniques and bacterial infections. J Neuroimaging. 2012;22:e42–51. Zhu L, Dong L, Li Y, Lu G, Zhang H, Wang X, et al. The diagnostic and antibiotic reference values of procalcitonin for intracranial infection after craniotomy. World Neurosurg. 2019;126:e1–7. Ramos FM, Delgado-Vélez M, Ortiz ÁL, Báez-Pagán CA, Quesada O, Lasalde-Dominicci JA. Expression of CHRFAM7A and CHRNA7 in neuronal cells and postmortem brain of HIV-infected patients: considerations for HIV-associated neurocognitive disorder. J Neurovirol. 2016;22:327–35. Bonfield CM, Sharma J, Dobson S. Pediatric intracranial abscesses. J Infect. 2015;71 Suppl 1:S42–6. Mo S, Wei L, Chen H, Li R, Li S, Luo G. A Chinese case of prevotella intermedia and Streptococcus constellatus intracranial mixed infection. Metab Brain Dis. 2018;33:161–6. Young GB. Encephalopathy of infection and systemic inflammation. J Clin Neurophysiol. 2013;30:454–61. Costantini TW, Chan TW, Cohen O, Langness S, Treadwell S, Williams E, et al. Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response. Proc Natl Acad Sci U S A. 2019;116:7932–40. Wu J, Zhang H, Xu Y, Zhang J, Zhu W, Zhang Y, et al. Juglone induces apoptosis of tumor stem-like cells through ROS-p38 pathway in glioblastoma. BMC Neurol. 2017;17:70. Zhang X, Zhao XD, Shi JX, Yin HX. Inhibition of the p38 mitogen-activated protein kinase (MAPK) pathway attenuates cerebral vasospasm following experimental subarachnoid hemorrhage in rabbits. Ann Clin Lab Sci. 2011;41:244–50. Zhang Y, Qian J, Ren H, Meng F, Ma R, Xu B. Human-specific CHRFAM7A protects against radiotherapy-induced lacrimal gland injury by inhibiting the p38/JNK signalling pathway and oxidative stress. Int J Clin Exp Pathol. 2017;10:9001–11. Article / Publication Details

First-Page Preview

Received: March 01, 2021
Accepted: November 08, 2021
Published online: January 31, 2022

Number of Print Pages: 11
Number of Figures: 6
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: https://www.karger.com/NIM

Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.