αSMA
alpha smooth muscle actin
ARCON
accelerated radiotherapy with carbogen and nicotinamide
CAF
cancer-associated fibroblast
cfDNA
circulating-free DNA
CPS
combined positive score
CTC
circulating tumor cells
ctDNA
circulating tumor DNA
CTLA-4
cytotoxic T lymphocyte antigen 4
DAHANCA
Danish Head and Neck Cancer Group
DDR1
discoidin domain receptor 1
EGFR
epidermal growth factor receptor
EMA
European Medicines Agency
EMT
epithelial-to-mesenchymal transition
EORTC
European Organization for Research and Treatment of Cancer
FAP
fibroblast activation protein
FAZA
18F-fluoroazomycin arabinoside
FDA
Food and Drug Administration
FDG
18F-fluoro-2-deoxy-D-glucose
FGF
fibroblast growth factor
FGFR
fibroblast growth factor receptor
HGF
hepatocyte growth factor
HIF
hypoxia-inducible factor
MATH
mutant allele tumor heterogeneity
MCAM
melanoma cell adhesion molecule
MCT
monocarboxylate transporter
MRI
magnetic resonance imaging
NGS
next-generation sequencing
OPSCC
oropharyngeal squamous cell carcinoma
OSCC
oral squamous cell carcinoma
OXPHOS
oxidative phosphorylation
PBMC
peripheral blood mononuclear cell
PD-1
programmed cell death-1
PD-L1
programmed cell death ligand 1
PDTO
patient-derived tumor organoid
PDTX
patient-derived tumor xenograft
PET
positron emission tomography
PFS
progression-free survival
SCCHN
squamous cell carcinoma of the head and neck
scRNA-seq
single-cell RNA sequencing
TAM
tumor-associated macrophage
TAZ
transcriptional coactivator with PDZ-binding motif
TCGA
The Cancer Genome Atlas
TGF-β
transforming growth factor beta
TIGIT
T cell immunoglobin and immunoreceptor tyrosine based inhibitory motif
TiME
tumor immune microenvironment
TMB
tumor mutational burden
TME
tumor microenvironment
TPS
tumor proportion score
YAP
Yes-associated protein 1
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