Impact of Ursodeoxycholic Acid in Critically Ill Patients With Sepsis: A Retrospective Study

1. Singer, M, Deutschman, CS, Seymour, CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). J Am Med Assoc. 2016;315(8):801–810.
Google Scholar | Crossref | Medline | ISI2. Chand, N, Sanyal, AJ. Sepsis-induced cholestasis. Hepatology. 2007;45(1):230–241.
Google Scholar | Crossref | Medline | ISI3. Haussner, F, Halbgebauer, R, Chakraborty, S, Huber-Lang, M. Challenge to the intestinal mucosa during sepsis. Front Immunol. 2019;10:891.
Google Scholar | Crossref | Medline4. Welsh, FK, Ramsden, CW, MacLennan, K, et al. Increased intestinal permeability and altered mucosal immunity in cholestatic jaundice. Ann Surg. 1998;227(2):205–212.
Google Scholar | Crossref | Medline5. Yan, J, Li, S, Li, S. The role of the liver in sepsis. Int Rev Immunol. 2014;33(6):498–510.
Google Scholar | Crossref | Medline6. Chaudhry, H, Zhou, J, Zhong, Y, et al. Role of cytokines as a double-edged sword in sepsis. In vivo. 2013;27(6):669–684.
Google Scholar | Medline7. Van Amersfoort, ES, Van Berkel, TJ, Kuiper, J. Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock. Clin Microbiol Rev. 2003;16(3):379–414.
Google Scholar | Crossref | Medline8. Nesseler, N, Launey, Y, Aninat, C, Morel, F, Malledant, Y, Seguin, P. Clinical review: the liver in sepsis. Crit Care. 2012;16(5):235. doi:10.1186/cc11381
Google Scholar | Crossref | Medline9. Field, E, Horst, HM, Rubinfeld, IS, et al. Hyperbilirubinemia: A risk factor for infection in the surgical intensive care unit. Am J Surg. 2008;195(3):304–307.
Google Scholar | Crossref | Medline10. Patel, JJ, Taneja, A, Niccum, D, Kumar, G, Jacobs, E, Nanchal, R. The association of serum bilirubin levels on the outcomes of severe sepsis. J Intensive Care Med. 2015;30(1):23–29.
Google Scholar | SAGE Journals | ISI11. Zhai, R, Sheu, CC, Su, L, et al. Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis. Thorax. 2009;64(9):784–790.
Google Scholar | Crossref | Medline12. Kobashi, H, Toshimori, J, Yamamoto, K. Sepsis-associated liver injury: Incidence, classification and the clinical significance. Hepatol Res. 2013;43(3):255–266. doi:10.1111/j.1872-034x.2012.01069.x
Google Scholar | Crossref | Medline13. Nesseler, N, Launey, Y, Aninat, C, et al. Liver dysfunction is associated with long-term mortality in septic shock. Am J Respir Crit Care Med. 2016;193(3):335–337. doi:10.1164/rccm.201508-1660le
Google Scholar | Crossref | Medline14. Roma, MG, Toledo, FD, Boaglio, AC, Basiglio, CL, Crocenzi, FA, Sánchez Pozzi, EJ. Ursodeoxycholic acid in cholestasis: Linking action mechanisms to therapeutic applications. Clin Sci. 2011;121(12):523–544.
Google Scholar | Crossref15. Festi, D, Montagnani, M, Azzaroli, F, et al. Clinical efficacy and effectiveness of ursodeoxycholic acid in cholestatic liver diseases. Curr Clin Pharmacol. 2007;2(2):155–177.
Google Scholar | Crossref | Medline16. Beuers, U, Trauner, M, Jansen, P, Poupon, R. New paradigms in the treatment of hepatic cholestasis: From UDCA to FXR, PXR and beyond. J Hepatol. 2015;62(1 suppl):S25–S37.
Google Scholar | Crossref | Medline17. Bessone, F, Roma, MG. Is ursodeoxycholic acid detrimental in obstructive cholestasis? A propos of a case of malignant biliary obstruction. Ann Hepatol. 2016;15(3):442–447.
Google Scholar | Crossref | Medline18. Razori, MV, Maidagan, PM, Ciriaci, N, et al. Anticholestatic mechanisms of ursodeoxycholic acid in lipopolysaccharide-induced cholestasis. Biochem Pharmacol. 2019;168:48–56.
Google Scholar | Crossref | Medline19. Nee, PA . Critical care in the emergency department: Severe sepsis and septic shock. Emerg Med J. 2006;23(9):713–717. doi:10.1136/emj.2005.029934
Google Scholar | Crossref | Medline20. Canabal, JM, Kramer, DJ. Management of sepsis in patients with liver failure. Curr Opin Crit Care. 2008;14(2):189–197. doi:10.1097/MCC.0b013e3282f6a435
Google Scholar | Crossref | Medline21. Foreman, MG, Mannino, DM, Moss, M. Cirrhosis as a risk factor for sepsis and death: analysis of the National Hospital Discharge Survey. Chest. 2003;124(3):1016–1020. doi:10.1378/chest.124.3.1016
Google Scholar | Crossref | Medline22. Wong, F, Bernardi, M, Balk, R, et al. Sepsis in cirrhosis: report on the 7th meeting of the International Ascites Club. Gut. 2005;54(5):718–725. doi:10.1136/gut.2004.038679
Google Scholar | Crossref | Medline23. Papastergiou, V, Tsochatzis, EA, Rodriguez-Peralvarez, M, et al. Biochemical criteria at 1 year are not robust indicators of response to ursodeoxycholic acid in early primary biliary cirrhosis: results from a 29-year cohort study [published correction appears in Aliment Pharmacol Ther. Aliment Pharmacol Ther. 2014;38(11–12):904–1364. doi:10.1111/apt.12522
Google Scholar | Crossref24. Lammert, C, Juran, BD, Schlicht, E, et al. Biochemical response to ursodeoxycholic acid predicts survival in a North American cohort of primary biliary cirrhosis patients. J Gastroenterol. 2014;49(10):1414–1420. doi:10.1007/s00535-013-0903-1
Google Scholar | Crossref | Medline25. Fuchs, M, Sanyal, AJ. Sepsis and cholestasis. Clin Liver Dis. 2008;12(1):151–159. doi:10.1016/j.cld.2007.11.002
Google Scholar | Crossref | Medline26. Geier, A, Fickert, P, Trauner, M. Mechanisms of disease: mechanisms and clinical implications of cholestasis in sepsis. Nat Clin Pract Gastroenterol Hepatol. 2006;3(10):574–585. doi:10.1038/ncpgasthep0602
Google Scholar | Crossref | Medline27. Işık, S, Karaman, M, Çilaker Micili, S, et al. Beneficial effects of ursodeoxycholic acid via inhibition of airway remodelling, apoptosis of airway epithelial cells, and Th2 immune response in murine model of chronic asthma. Allergol Immunopathol. 2017;45(4):339–349.
Google Scholar | Crossref | Medline28. Niu, F, Xu, X, Zhang, R, Sun, L, Gan, N, Wang, A. Ursodeoxycholic acid stimulates alveolar fluid clearance in LPS-induced pulmonary edema via ALX/cAMP/PI3K pathway. J Cell Physiol. 2019;234(11):20057–20065. doi:10.1002/jcp.28602
Google Scholar | Crossref | Medline29. Ainosah, RH, Hagras, MM, E Alharthi, S, Saadah, OI. The effects of ursodeoxycholic acid on sepsis-induced cholestasis management in an animal model. J Taibah Univ Med Sci. 2020;15(4):312–320.
Google Scholar | Crossref | Medline30. Rina, R, Oswari, H, Amalia, P. Ursodeoxycholic acid in neonatal sepsis-associated cholestasis. Paediatr Indones. 2014;54(4):206. doi:10.14238/pi54.4.2014.206-12
Google Scholar | Crossref31. Niu, F, Li, H, Xu, X, Sun, L, Gan, N, Wang, A. Ursodeoxycholic acid protects against lung injury induced by fat embolism syndrome. J Cell Mol Med. 2020;24(24):14626–14632. doi:10.1111/jcmm.15985
Google Scholar | Crossref | Medline

留言 (0)

沒有登入
gif