Figure S1. The flow chart of collecting publications for analyzing the association between rs864745 polymorphism and T2D.

Figure S2. The interactive heatmap matrix of pairwise linkage disequilibrium of GWAS catalog (rs34824357, rs1635852, rs849133, rs860262, rs849134, rs849135, rs1708302 and rs1513272).

Figure S3. Skeletal muscle JAZF1 eQTLs and GWAS associations with T2D. LocusCompare plot showing the relationship between muscle JAZF1 eQTLs and GWAS associations with T2D for variants located within 2kb of JAZF1. Colocalization PP4=75.09%. The lead GWAS variant (rs4722760) is annotated.

Figure S4. Meta-analysis of SNP rs864745 in subgroup analysis.

Figure S5. The RT-PCR amplification of either the complementary region or non-complementary region of BACE1 and BACE1-AS mRNA (positive control) and GAPDH (negative control) by RNase protection assay.

Figure S6. The regulation of JAZF1-AS1 upon muscular lipid oxidation. (A) The MDA level was assessed by ELISA kits, and AICAR increases level of muscle cellular lipid metabolism. & indicates P<0.05.; (B) The expression levels of lipid oxidation related genes were determined by qPCR. Data are mean ± SEM (N=3). * indicates P<0.05, ** indicates P<0.01 and *** indicates P<0.001, comparing with si-control group; # indicates P<0.05, ## indicates P<0.01 and ### indicates P<0.001, comparing with si-JAZF1-AS1 group.

Table S1. Main information of these studies used to analyze the association between rs864745 polymorphism and T2D.

Table S2. Main information of 7 GEO datasets for association analysis.

Table S3. Primers used in this study.

Table S4. Antibodies used for Western Blot.

Table S5. The results of heterogeneity test and meta-analysis in subgroup analysis.