Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced Mice

Bhattacharya A, Jones DNC (2018) Emerging role of the P2X7-NLRP3-IL1beta pathway in mood disorders. Psychoneuroendocrinology 98:95–100

CAS  Article  Google Scholar 

Bygdeman S, Kallings I, Danielsson D (1981) Serogrouping and auxotyping for epidemiological study of beta-lactamase-producing Neisseria gonorrhoeae strains isolated in Sweden. Acta Derm Venereol 61:329–334

CAS  PubMed  Google Scholar 

Cheng J, Chen M, Zhu JX, Li CF, Zhang QP, Geng D, Liu Q, Yi LT (2019) FGF-2 signaling activation in the hippocampus contributes to the behavioral and cellular responses to puerarin. Biochem Pharmacol 168:91–99

CAS  Article  Google Scholar 

Coll RC et al (2015) A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med 21:248–255

CAS  Article  Google Scholar 

Cornell J, Salinas S, Huang HY, Zhou M (2022) Microglia regulation of synaptic plasticity and learning and memory. Neural Regen Res 17:705–716

Article  Google Scholar 

Dempsey C, Araiz AR, Bryson KJ, Finucane O, Larkin C, Mills EL, Robertson AAB, Cooper MA, O’Neill LAJ, Lynch MA (2017) Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-beta and cognitive function in APP/PS1 mice. Brain Behav Immun 61:306–316

CAS  Article  Google Scholar 

Dolunay A, Senol SP, Temiz-Resitoglu M, Guden DS, Sari AN, Sahan-Firat S, Tunctan B (2017) Inhibition of NLRP3 Inflammasome Prevents LPS-Induced Inflammatory Hyperalgesia in Mice: Contribution of NF-kappaB, Caspase-1/11, ASC, NOX, and NOS Isoforms. Inflammation 40:366–386

CAS  Article  Google Scholar 

Dong Y, Li S, Lu Y, Li X, Liao Y, Peng Z, Li Y, Hou L, Yuan Z, Cheng J (2020) Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice. J Neuroinflammation 17:205

CAS  Article  Google Scholar 

Du RH, Tan J, Sun XY, Lu M, Ding JH, Hu G (2016) Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression. Int J Neuropsychopharmacol 19

Goshen I, Yirmiya R (2009) Interleukin-1 (IL-1): a central regulator of stress responses. Front Neuroendocrinol 30:30–45

CAS  Article  Google Scholar 

Hellwig S, Brioschi S, Dieni S, Frings L, Masuch A, Blank T, Biber K (2016) Altered microglia morphology and higher resilience to stress-induced depression-like behavior in CX3CR1-deficient mice. Brain Behav Immun 55:126–137

Article  Google Scholar 

Himmerich H, Patsalos O, Lichtblau N, Ibrahim MAA, Dalton B (2019) Cytokine research in depression: principles, challenges, and open questions. Front Psychiatry 10:30

Article  Google Scholar 

Idova GV, Markova EV, Gevorgyan MM, Al’perina EL, Zhanaeva SY (2018) Cytokine production by splenic cells in C57BL/6J mice with depression-like behavior depends on the duration of social stress. Bull Exp Biol Med 164:645–649

CAS  Article  Google Scholar 

Ising C et al (2019) NLRP3 inflammasome activation drives tau pathology. Nature 575:669–673

CAS  Article  Google Scholar 

Ismael S, Nasoohi S, Li L, Aslam KS, Khan MM, El-Remessy AB, McDonald MP, Liao FF, Ishrat T (2021) Thioredoxin interacting protein regulates age-associated neuroinflammation. Neurobiol Dis 156:105399

Izquierdo P, Shiina H, Hirunpattarasilp C, Gillis G, Attwell D (2021) Synapse development is regulated by microglial THIK-1 K(+) channels. Proc Natl Acad Sci U S A 118

Kelley N, Jeltema D, Duan Y, He Y (2019) The NLRP3 inflammasome: an overview of mechanisms of activation and regulation. Int J Mol Sci 20

Kinoshita S, Koyama R (2021) Pro- and anti-epileptic roles of microglia. Neural Regen Res 16:1369–1371

Article  Google Scholar 

Krugel U, Fischer J, Radicke S, Sack U, Himmerich H (2013) Antidepressant effects of TNF-alpha blockade in an animal model of depression. J Psychiatr Res 47:611–616

Article  Google Scholar 

Lang L, Xu B, Yuan J, Li S, Lian S, Chen Y, Guo J, Yang H (2020) GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-kappaB signaling pathways. Int Immunopharmacol 89:106908

Li W, Niu L, Liu Z, Xu X, Shi M, Zhang Y, Deng Y, He J, Xu Y, Wan W, Sun Q, Zhong X, Cao W (2021) Inhibition of the NLRP3 inflammasome with MCC950 prevents chronic social isolation-induced depression-like behavior in male mice. Neurosci Lett 136290

Liu JJ, Wei YB, Strawbridge R, Bao Y, Chang S, Shi L, Que J, Gadad BS, Trivedi MH, Kelsoe JR, Lu L (2020) Peripheral cytokine levels and response to antidepressant treatment in depression: a systematic review and meta-analysis. Mol Psychiatry 25:339–350

CAS  Article  Google Scholar 

Liu MY, Yin CY, Zhu LJ, Zhu XH, Xu C, Luo CX, Chen H, Zhu DY, Zhou QG (2018) Sucrose preference test for measurement of stress-induced anhedonia in mice. Nat Protoc 13:1686–1698

CAS  Article  Google Scholar 

Lorentz A, Bischoff SC (2001) Regulation of human intestinal mast cells by stem cell factor and IL-4. Immunol Rev 179:57–60

CAS  Article  Google Scholar 

Lu Y, Xu X, Jiang T, Jin L, Zhao XD, Cheng JH, Jin XJ, Ma J, Piao HN, Piao LX (2019) Sertraline ameliorates inflammation in CUMS mice and inhibits TNF-alpha-induced inflammation in microglia cells. Int Immunopharmacol 67:119–128

CAS  Article  Google Scholar 

Pan Y, Chen XY, Zhang QY, Kong LD (2014) Microglial NLRP3 inflammasome activation mediates IL-1beta-related inflammation in prefrontal cortex of depressive rats. Brain Behav Immun 41:90–100

CAS  Article  Google Scholar 

Prinz M, Jung S, Priller J (2019) Microglia biology: one century of evolving concepts. Cell 179:292–311

CAS  Article  Google Scholar 

Rimmerman N et al (2021) Microglia and their LAG3 checkpoint underlie the antidepressant and neurogenesis-enhancing effects of electroconvulsive stimulation. Mol Psychiatry.

Schiepers OJ, Wichers MC, Maes M (2005) Cytokines and major depression. Prog Neuropsychopharmacol Biol Psychiatry 29:201–217

CAS  Article  Google Scholar 

Slavich GM, Sacher J (2019) Stress, sex hormones, inflammation, and major depressive disorder: extending social signal transduction theory of depression to account for sex differences in mood disorders. Psychopharmacology (Berl) 236:3063–3079

CAS  Article  Google Scholar 

Song L, Pei L, Yao S, Wu Y, Shang Y (2017) NLRP3 inflammasome in neurological diseases, from functions to therapies. Front Cell Neurosci 11:63

PubMed  PubMed Central  Google Scholar 

Szepesi Z, Manouchehrian O, Bachiller S, Deierborg T (2018) Bidirectional microglia-neuron communication in health and disease. Front Cell Neurosci 12:323

CAS  Article  Google Scholar 

Wang Y, Xu Y, Sheng H, Ni X, Lu J (2016) Exercise amelioration of depression-like behavior in OVX mice is associated with suppression of NLRP3 inflammasome activation in hippocampus. Behav Brain Res 307:18–24

CAS  Article  Google Scholar 

Wang Y, Che M, Xin J, Zheng Z, Li J, Zhang S (2020) The role of IL-1beta and TNF-alpha in intervertebral disc degeneration. Biomed Pharmacother 131:110660

Wang YL, Wu HR, Zhang SS, Xiao HL, Yu J, Ma YY, Zhang YD, Liu Q (2021) Catalpol ameliorates depressive-like behaviors in CUMS mice via oxidative stress-mediated NLRP3 inflammasome and neuroinflammation. Transl Psychiatry 11:353

CAS  Article  Google Scholar 

Weber ANR, Bittner ZA, Shankar S, Liu X, Chang TH, Jin T, Tapia-Abellan A (2020) Recent insights into the regulatory networks of NLRP3 inflammasome activation. J Cell Sci 133:jcs248344

Willner P (2017) The chronic mild stress (CMS) model of depression: history, evaluation and usage. Neurobiol Stress 6:78–93

Article  Google Scholar 

Wu AG, Zhou XG, Qiao G, Yu L, Tang Y, Yan L, Qiu WQ, Pan R, Yu CL, Law BY, Qin DL, Wu JM (2021) Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases. Ageing Res Rev 65:101202

Xu Y, Sheng H, Bao Q, Wang Y, Lu J, Ni X (2016) NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice. Brain Behav Immun 56:175–186

CAS  Article  Google Scholar 

Yang J, Wise L, Fukuchi KI (2020) TLR4 cross-talk with NLRP3 inflammasome and complement signaling pathways in alzheimer’s disease. Front Immunol 11:724

CAS  Article  Google Scholar 

Yankelevitch-Yahav R, Franko M, Huly A, Doron R (2015) The forced swim test as a model of depressive-like behavior. J Vis Exp

Yi LT, Zhang MM, Cheng J, Wan HQ, Li CF, Zhu JX, Zhang QP, Liu Q, Xu GH (2021) Antidepressant-like Effects of Degraded Porphyran Isolated from Porphyra haitanensis. Mol Nutr Food Res 65:e2000869

Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D’Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD (2015) The ketone metabolite beta-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med 21:263–269

CAS  Article  Google Scholar 

Yu Q, Zhao T, Liu M, Cao D, Li J, Li Y, Xia M, Wang X, Zheng T, Liu C, Mu X, Sun P (2021) Targeting NLRP3 inflammasome in translational treatment of nervous system diseases: an update. Front Pharmacol 12:707696

Zhai Y, Meng X, Ye T, Xie W, Sun G, Sun X (2018) Inhibiting the NLRP3 inflammasome activation with MCC950 ameliorates diabetic encephalopathy in db/db mice. Molecules 23

Zhu W, Cao FS, Feng J, Chen HW, Wan JR, Lu Q, Wang J (2017) NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide. Neuroscience 343:77–84

CAS  Article  Google Scholar 

留言 (0)

沒有登入
gif