Introduction/Aims

A number of signs of selective involvement have been reported in amyotrophic lateral sclerosis (ALS). In this study, we describe two new ones, “weak shoulder” and “arm sparing” signs.

Methods

Subjects were retrospectively identified from our electrodiagnosis database. Medical Research Council scores of relevant muscles were evaluated. Weak shoulder was defined as the deltoid (Del) muscle being weaker than the biceps brachii (BB)/ triceps brachii (TB) muscles, i.e. Del was weaker than either or both of the two muscles and no stronger than either. Arm sparing was defined as both Del and the first dorsal interosseous (FDI) being weaker than BB/TB. Sensitivities of these signs were compared with other signs of selective involvement. The specificities of these signs were investigated in patients with cervical spondylotic amyotrophy (CSA) and multifocal motor neuropathy (MMN).

Results

We reviewed 130 patients with ALS, 64 patients with CSA, and 16 patients with MMN. The weak shoulder and the arm sparing signs were observed in 73% and 55% of patients with ALS, 44% and 2% of patients with CSA (93% and 0% of patients with proximal CSA), respectively, and no patients with MMN. The sensitivity of the weak shoulder was higher than conventional signs, whereas that of the arm sparing sign was no different from them.

Discussion

The weak shoulder sign was highly sensitive in ALS, and was specific in comparison with MMN. The arm sparing sign was highly specific for ALS. The two new signs are promising as clinical clues to diagnosing ALS.