A 10-fold and greater increase in D-dimer at admission in COVID-19 patients is highly predictive of pulmonary embolism in a retrospective cohort study

1. Guan, WJ, Ni, ZY, Hu, Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020; 382: 1708–1720.
Google Scholar | Crossref | Medline2. Yang, X, Yu, Y, Xu, J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med 2020; 8: 475–481.
Google Scholar | Crossref | Medline3. Zhang, L, Yan, X, Fan, Q, et al. D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19. J Thromb Haemost 2020; 18: 1324–1329.
Google Scholar | Crossref | Medline4. Chen, T, Wu, D, Chen, H, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ 2020; 368: m1091.
Google Scholar | Crossref | Medline5. Cui, S, Chen, S, Li, X, et al. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost 2020; 18: 1421–1424.
Google Scholar | Crossref | Medline6. Zhou, F, Yu, T, Du, R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395: 1054–1062.
Google Scholar | Crossref | Medline7. Helms, J, Tacquard, C, Severac, F, et al. High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study. Intensive Care Med 2020; 46: 1089–1098.
Google Scholar | Crossref | Medline8. Klok, FA, Kruip, MJHA, van der Meer, NJM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res 2020; 191: 145–147.
Google Scholar | Crossref | Medline9. Leonard-Lorant, I, Delabranche, X, Severac, F, et al. Acute pulmonary embolism in patients with COVID-19 at CT angiography and relationship to D-dimer levels. Radiology 2020; 296: E189–E191.
Google Scholar | Crossref | Medline10. Middeldorp, S, Coppens, M, van Haaps, TF, et al. Incidence of venous thromboembolism in hospitalized patients with COVID-19. J Thromb Haemost 2020; 18: 1995–2002.
Google Scholar | Crossref | Medline11. Ackermann, M, Verleden, SE, Kuehnel, M, et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N Engl J Med 2020; 383: 120–128.
Google Scholar | Crossref | Medline12. Wichmann, D, Sperhake, JP, Lutgehetmann, M, et al. Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Ann Intern Med 2020; 173: 268–277.
Google Scholar | Crossref | Medline13. Connors, JM, Levy, JH. Thromboinflammation and the hypercoagulability of COVID-19. J Thromb Haemost 2020; 18: 1559–1561.
Google Scholar | Crossref | Medline14. Ciceri, F, Beretta, L, Scandroglio, AM, et al. Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis. Crit Care Resusc 2020; 22: 95–97.
Google Scholar | Medline15. Cattaneo, M, Bertinato, EM, Birocchi, S, et al. Pulmonary embolism or pulmonary thrombosis in COVID-19? Is the recommendation to use high-dose heparin for thromboprophylaxis justified? Thromb Haemost 2020; 120: 1230–1232.
Google Scholar | Crossref | Medline16. Thachil, J, Tang, N, Gando, S, et al. ISTH interim guidance on recognition and management of coagulopathy in COVID-19. J Thromb Haemost 2020; 18: 1023–1026.
Google Scholar | Crossref | Medline17. Spyropoulos, AC, Levy, JH, Ageno, W, et al. Scientific and Standardization Committee Communication: clinical guidance on the diagnosis, prevention, and treatment of venous thromboembolism in hospitalized patients with COVID-19. J Thromb Haemost 2020; 18: 1859–1865.
Google Scholar | Crossref | Medline18. Wells, PS, Anderson, DR, Rodger, M, et al. Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and D-dimer. Ann Intern Med 2001; 135: 98–107.
Google Scholar | Crossref | Medline | ISI19. Konstantinides, SV, Meyer, G, Becattini, C, et al. 2019 ESC guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). Eur Respir J 2019; 54: 1901647.
Google Scholar | Crossref | Medline20. NG158 . Venous thromboembolic diseases: diagnosis, management and thrombophilia testing – NICE guideline, www.nice.org.uk/guidance/ng158 (March 2020, accessed 10 May 2020).
Google Scholar21. Docherty, AB, Harrison, EM, Green, CA, et al. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. BMJ 2020; 369: m1985.
Google Scholar | Crossref | Medline22. HRA , https://www.hra.nhs.uk/covid-19-research/guidance-using-patient-data/ (2020, accessed 27 September 2020).
Google Scholar23. Nopp, S, Moik, F, Jilma, B, et al. Risk of venous thromboembolism in patients with COVID-19: a systematic review and meta-analysis. Res Pract Thromb Haemost 2020; 4: 1178–1191.
Google Scholar | Crossref24. Freund, Y, Drogrey, M, Miró, Ò, et al. Association between pulmonary embolism and COVID-19 in emergency department patients undergoing computed tomography pulmonary angiogram: the PEPCOV International Retrospective Study. Acad Emerg Med 2020; 27: 811–820.
Google Scholar | Crossref | Medline25. Ruan, Q, Yang, K, Wang, W, et al. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med 2020; 46: 846–848.
Google Scholar | Crossref | Medline26. Wang, G, Wu, C, Zhang, Q, et al. C reactive protein level may predict the risk of COVID-19 aggravation. Open Forum Infect Dis 2020; 7: ofaa153.
Google Scholar | Crossref27. Garcia-Olivé, I, Sintes, H, Radua, J, et al. D-dimer in patients infected with COVID-19 and suspected pulmonary embolism. Respir Med 2020; 169: 106023.
Google Scholar | Crossref | Medline28. Yao, Y, Cao, J, Wang, Q, et al. D-dimer as a biomarker for disease severity and mortality in COVID-19 patients: a case control study. J Intensive Care 2020; 8: 49.
Google Scholar | Crossref | Medline29. Schouten, HJ, Geersing, GJ, Koek, HL, et al. Diagnostic accuracy of conventional or age adjusted D-dimer cut-off values in older patients with suspected venous thromboembolism: systematic review and meta-analysis. BMJ 2013; 346: f2492.
Google Scholar | Crossref | Medline30. Sikora-Skrabaka, M, Skrabaka, D, Ruggeri, P, et al. D-dimer value in the diagnosis of pulmonary embolism-may it exclude only. J Thorac Dis 2019; 11: 664–672.
Google Scholar | Crossref | Medline31. Ventura-Díaz, S, Quintana-Pérez, JV, Gil-Boronat, A, et al. A higher D-dimer threshold for predicting pulmonary embolism in patients with COVID-19: a retrospective study. Emerg Radiol 2020; 27: 679–689.
Google Scholar | Crossref | Medline

留言 (0)

沒有登入
gif