Caregivers, whether a biological parent, adoptive parent, or a relative such as a grandparent, of adolescent with substance use disorder (SUD) undergo immense psychological and social strains, as they have to deal with substance habituated issues arising from their adolescent child. Caregivers often encounter many untold experiences while parenting adolescents on substance use. However, there is limited documentation of such experiences. A remarkable proportion of research has focused on adolescent substance use and the experiences of adolescents, whereas little attention has been paid to caregivers. This study explored the psychological experiences of caregivers of adolescents diagnosed with SUD. This was a qualitative study based on in-depth interviews with 18 caregivers of adolescents with SUD conducted at a Youth Centre located in a national referral hospital and focused on the caregivers’ psychological experiences. Data collected through in-depth interviews were transcribed and thematically coded. Recurrent themes were analysed and reported. The study identified several themes in the experiences of caregivers of adolescents with SUDs. The main psychological experience was stress, whereas lasting psychological effects as well as difficult social outcomes as a result of substance use by the adolescent child were also identified. This study revealed the complex landscape of psychological turmoil that the caregivers have to navigate while caring for an adolescent diagnosed with SUD.