Therapeutic potential of targeting regulatory mechanisms of hepatic stellate cell activation in liver fibrosis

Kaveh Baghaei is a principle investigator at the Shahid Beheshti Medical University-Research Institute of Gastroenterology and Liver Disease. He leads the Applied Cell Biology group and focuses particularly on new avenues for translating cell therapy and drug-repurposing approaches into the clinic .

Sogol Mazhari Sogol Mazhari was awarded a BSc in cellular and molecular biology by the University of Shiraz (Iran) and an MSc in microbiology by the University of Shahid Beheshti (Iran). In 2017, she began a research project at RIGLD (Iran) studying the antifibrotic impacts of imatinib and mesenchymal stem cells on liver fibrosis. Since 2018, she has been working on developing therapeutical approaches against hepatic fibrosis. Her main research interests are stem cells and immunotherapy.

Saeid Ghavami Saeid Ghavami is currently an associate professor in the Department of Human Anatomy and Cell Science, University of Manitoba, Canada; an honorary professor and co-founder of the Autophagy Research Centre at Shiraz University of Medical Science; and an honorary professor at Katowice School of Technology, Poland. He is a section editor of BBA-Molecular Basis of Disease, associate editor of Molecular Neurobiology, BB Reports, International Journal of Molecular Science, and Academic Editor of PLoS ONE. He was awarded a BSc in Chemistry in 1989 by Shiraz University, Shiraz, Iran), and an MSc and PhD in clinical biochemistry in 1995 and 2004, respectively, by TMU University, Tehran, Iran. His research focuses on the effects of apoptosis, autophagy, and the unfolded protein response in the regulation of cell fate.

Dedmer Schaafsma Dedmer Schaafsma received his PhD in mathematics and natural sciences (specializing in molecular pharmacology) with honors from The University of Groningen. He is currently the CEO of Science Impact (Winnipeg, Canada). His expertise lies within identifying molecular signaling mechanisms that drive phenotypic modulation of cells contributing to profibrotic and inflammatory diseases, such as allergic asthma.

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