A metal-organic framework ZJU-136-Ce with ideal water stability was synthesized. It was adopted to load Mn 2+ and DOX for chemo/chemodynamic therapy of tumor, the loading capacity of Mn 2+ and DOX was 0.87 wt% and 10.19 wt% in ZJU-136-Ce, respectively. DOX&Mn@ZJU-136-Ce exhibited significant effects of inhibition of Hela cell growth, which confirmed it had a potential application prospect in the multimodal cancer therapy .