Asymmetric Henry reaction of trifluoromethyl enones with nitromethane using a N,N‐dibenzyl diaminomethylenemalononitrile organocatalyst

A novel N,N -dibenzyl diaminomethylenemalononitrile organocatalyst efficiently promoted asymmetric Henry reactions of trifluoromethyl enones with nitromethane, affording corresponding highly functionalized products in high yields with excellent enantioselectivities (up to 90% ee). This study is the first to report the successful example of the asymmetric 1,2-additions of nitromethane to trifluoromethyl enones.

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