1. Papanikolaou, G, Pantopoulos, K. Systemic iron homeostasis and erythropoiesis. IUBMB Life 2017;69:399–413.
Google Scholar | Crossref | Medline2. Angelucci, E, Brittenham, GM, McLaren, CE, et al. Hepatic iron concentration and total body iron stores in thalassemia major. N Engl J Med 2000;343:327–331.
Google Scholar | Crossref | Medline3. Fan, JG, Kim, SU, Wong, VW. New trends on obesity and NAFLD in Asia. J Hepatol 2017;67:862–873.
Google Scholar | Crossref | Medline4. Maliken, BD, Nelson, JE, Klintworth, HM, et al. Hepatic reticuloendothelial system cell iron deposition is associated with increased apoptosis in nonalcoholic fatty liver disease. Hepatology 2013;57:1806–1813.
Google Scholar | Crossref | Medline5. Marmur, J, Beshara, S, Eggertsen, G, et al. Hepcidin levels correlate to liver iron content, but not steatohepatitis, in non-alcoholic fatty liver disease. BMC Gastroenterol 2018;18:78.
Google Scholar | Crossref | Medline6. Xue’e, P, Shishen, X, Wei, L, et al. The combination and comprehensive influence of iron in the diet and the influence of selected risk factors on the risk of NAFLD in the Chinese population. Sci Rep 2019;9:4069.
Google Scholar | Crossref | Medline7. Powell, EE, Ali, A, Clouston, AD, et al. Steatosis is a cofactor in liver injury in hemochromatosis. Gastroenterology 2005;129:1937–1943.
Google Scholar | Crossref | Medline8. Wu, Q, Fu, X, Zhuo, Z, et al. The application value of ultra-short echo time MRI in the quantification of liver iron overload in a rat model. Quant Imaging Med Surg 2019;9:180–187.
Google Scholar | Crossref | Medline9. Peng, P, Huang, Z, Long, L, et al. Liver iron quantification by 3 Tesla MRI: calibration on a rabbit model. J Magn Reson Imaging 2013;38:1585–1590.
Google Scholar | Crossref | Medline10. Henninger, B, Alustiza, J, Garbowski, M, et al. Practical guide to quantification of hepatic iron with MRI. Eur Radiol 2020;30:383–393.
Google Scholar | Crossref | Medline11. Galimberti, S, Trombini, P, Bernasconi, DP, et al. Simultaneous liver iron and fat measures by magnetic resonance imaging in patients with hyperferritinemia. Scand J Gastroenterol 2015;50:429–438.
Google Scholar | Crossref | Medline12. Sharma, P, Altbach, M, Galons, JP, et al. Measurement of liver fat fraction and iron with MRI and MR spectroscopy techniques. Diagn Interv Radiol 2014;20:17–26.
Google Scholar | Medline13. Fukuzawa, K, Hayashi, T, Takahashi, J, et al. Evaluation of six-point modified Dixon and magnetic resonance spectroscopy for fat quantification: a fat-water-iron phantom study. Radiol Phys Technol 2017;10:349–358.
Google Scholar | Crossref | Medline14. Henninger, B, Plaikner, M, Zoller, H, et al. Performance of different Dixon-based methods for MR liver iron assessment in comparison to a biopsy-validated R2* relaxometry method. Eur Radiol 2021;31:2252–2262.
Google Scholar | Crossref | Medline15. Hu, F, Yang, R, Huang, Z, et al. 3D multi-echo Dixon technique for simultaneous assessment of liver steatosis and iron overload in patients with chronic liver diseases: a feasibility study. Quant Imaging Med Surg 2019;9:1014–1024.
Google Scholar | Crossref | Medline16. Zhan, C, Olsen, S, Zhang, HC, et al. Detection of hepatic steatosis and iron content at 3 Tesla: comparison of two-point Dixon, quantitative multi-echo Dixon, and MR spectroscopy. Abdom Radiol (NY) 2019;44:3040–3048.
Google Scholar | Crossref | Medline17. Pineda, N, Sharma, P, Xu, Q, et al. Measurement of hepatic lipid: high-speed T2-corrected multiecho acquisition at 1H MR spectroscopy–a rapid and accurate technique. Radiology 2009;252:568–576.
Google Scholar | Crossref | Medline18. Satkunasingham, J, Besa, C, Bane, O, et al. Liver fat quantification: comparison of dual-echo and triple-echo chemical shift MRI to MR spectroscopy. Eur J Radiol 2015;84:1452–1458.
Google Scholar | Crossref | Medline19. National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals . Guide for the care and use of laboratory animals. 8th ed. Washington, DC: National Academies Press (US), 2011.
Google Scholar20. Zhong, X, Nickel, MD, Kannengiesser, SA, et al. Liver fat quantification using a multi-step adaptive fitting approach with multi-echo GRE imaging. Magn Reson Med 2014;72:1353–1365.
Google Scholar | Crossref | Medline21. Jhaveri, KS, Kannengiesser, SAR, Ward, R, et al. Prospective evaluation of an R2* method for assessing liver iron concentration (LIC) against FerriScan: derivation of the calibration curve and characterization of the nature and source of uncertainty in the relationship. J Magn Reson Imaging 2019;49:1467–1474.
Google Scholar | Crossref | Medline22. Olivieri, NF, Brittenham, GM. Iron-chelating therapy and the treatment of thalassemia [published correction appears in Blood 1997 Apr 1;89(7):2621]. Blood 1997;89:739–761.
Google Scholar | Crossref | Medline | ISI23. Sharma, P, Martin, DR, Pineda, N, et al. Quantitative analysis of T2-correction in single-voxel magnetic resonance spectroscopy of hepatic lipid fraction. J Magn Reson Imaging 2009;29:629–635.
Google Scholar | Crossref | Medline24. França, M, Alberich-Bayarri, Á, Martí-Bonmatí, L, et al. Accurate simultaneous quantification of liver steatosis and iron overload in diffuse liver diseases with MRI. Abdom Radiol (NY) 2017;42:1434–1443.
Google Scholar | Crossref | Medline25. d’Assignies, G, Paisant, A, Bardou-Jacquet, E, et al. Non-invasive measurement of liver iron concentration using 3-tesla magnetic resonance imaging: validation against biopsy. Eur Radiol 2018;28:2022–2030.
Google Scholar | Crossref | Medline26. St Pierre, TG, El-Beshlawy, A, Elalfy, M, et al. Multicenter validation of spin-density projection-assisted R2-MRI for the noninvasive measurement of liver iron concentration. Magn Reson Med 2014;71:2215–2223.
Google Scholar | Crossref | Medline