The Global initiative on asthma (GINA) strategy included major changes for the treatment of mild asthma in the 2020 version, that are even taken to a next level in 2021, leaving a preferred track with only rescue therapy with inhaled corticosteroid and formoterol (ICS-FORM) for step 1-2 in 12+ years-old. It has been questioned how solid the evidence behind these recommendations is.

We decided to independently conduct an in-depth analysis of published evidence based on a comprehensive evaluation of original articles and related appendices and publications, including quality of evidence and risk-of-bias per article. We first defined the major asthma treatment goals and proceeded to review how these were met in publications referenced in the main asthma guidelines.

For patients with GINA 2021 Step 1 characteristics the analysis supports GINA’s decision to avoid SABA monotherapy and to prefer ICS-FORM rescue with as alternative ICS rescue every time a SABA is used for ≥12 years, even though evidence is extrapolated from step 2 patients. For 6-11 year-olds we propose to consider ICS-FORM rescue as an alternative, as its use has been approved in this age-group, be it not as rescue-medication.

For patients with GINA 2021 Step 2 characteristics our proposal slightly differs from GINA 2021. We propose to continue avoiding the separate use of SABA, using ICS rescue whenever a fast-acting bronchodilator is taken (even with ICS maintenance). Also, the superiority of ICS-FORM rescue over classical step 2 treatment is not uniform and year-long experience is lacking. Consequently for now, both treatment options seem equal: ICS-FORM rescue or ICS maintenance with SABA (+ICS) rescue. For 6-11 year-olds ICS rescue every time a SABA is used has the advantage of lower total ICS dose; as alternative we suggest ICS-FORM rescue.

The best treatment option depends on patient characteristics and treatment goals. Recommendations should be reviewed as soon as new evidence becomes available.