1. Guo, S . Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms. J Endocrinol 2014; 220(2): T1–T23.
Google Scholar | Crossref | Medline2. Doshi Simit, M, Friedman, AN. Diagnosis and management of type 2 diabetic kidney disease. Clin J Am Soc Nephrol 2017; 12: 1366–1373.
Google Scholar | Crossref | Medline3. Genuth, S . Classification and diagnosis of diabetes mellitus. Med Clin North Am 1982; 66(6): 1191–1207.
Google Scholar | Crossref | Medline4. Zimmet, P, Alberti, KG, Magliano, DJ, et al. Diabetes mellitus statistics on prevalence and mortality: facts and fallacies. Nat Rev Endocrinol 2016; 12: 616–622.
Google Scholar | Crossref | Medline | ISI5. Nakhoul, FM, Miller-Lotan, R, Awaad, H, et al. Hypothesis - Haptoglobin genotype and diabetic nephropathy. Nat Clin Pract Nephrol 2007.
Google Scholar | Crossref | Medline6. Fowler, MJ . Microvascular and macrovascular complications of diabetes. Clin Diabetes 2011; 29(3): 116–122.
Google Scholar | Crossref7. Lim Andy, KH . Diabetic nephropathy – Complications and treatment. Int J Nephrol Renovasc Dis 2014; 7: 361–381.
Google Scholar | Medline8. Liang, S, Cai Guang, Y, Chen, XM, et al. Clinical and pathological factors associated with progression of diabetic nephropathy. Nephrology 2017; 22: 14–19.
Google Scholar | Crossref | Medline9. Cheung, N, Mitchell, P, Wong, TY. Diabetic retinopathy. Lancet 2010; 376: 124–136.
Google Scholar | Crossref | Medline | ISI10. Judith, L, O’Leary Olivia, E, Stitt Alan, W. The pathology associated with diabetic retinopathy. Vis Res 2017; 139: 7–14.
Google Scholar | Crossref | Medline11. Heng, LZ, Comyn, O, Peto, T, et al. Diabetic retinopathy: pathogenesis, clinical grading, management and future developments. Diabetic Med 2013; 30: 640–650.
Google Scholar | Crossref | Medline | ISI12. Wong, TY, Cheung, CMG, Larsen, M, et al. Diabetic retinopathy. Nat Rev Dis Prim 2016; 2: 16012.
Google Scholar | Crossref | Medline13. Sahajpal, NS, Goel, RK, Chaubey, A, et al. Pathological perturbations in diabetic retinopathy: hyperglycemia, AGEs, oxidative stress and inflammatory pathways. Curr Protein Pept Sci 2018; 20(1): 92–110.
Google Scholar | Crossref14. Ding, Y, Choi, ME. Autophagy in diabetic nephropathy. J Endocrinol 2015; 224: R15–R30.
Google Scholar | Crossref | Medline15. Levy, AP, Asleh, R, Blum, S, et al. Haptoglobin: basic and clinical aspects. Antioxid Redox Signaling 2010; 12: 293–304.
Google Scholar | Crossref | Medline | ISI16. Carranza, K, Veron, D, Cercado, A, et al. Aspectos celulares y moleculares de la nefropatía diabética, rol del VEGF-A. Nefrologia 2015; 35(2): 131–138.
Google Scholar | Crossref | Medline17. Lin, YC, Chang, YH, Yang, SY, et al. Update of pathophysiology and management of diabetic kidney disease. J Formos Med Assoc 2018; 117: 662–675.
Google Scholar | Crossref | Medline18. Nakhoul, R, Nakhoul, F, Nakhoul, N Diabetic nephropathy from RAAS to autophagy: the era for new players. J Clin Exp Nephrol 2017; 2(3).
Google Scholar | Crossref | Medline19. Ruggenenti, P, Cravedi, P, Remuzzi, G. The RAAS in the pathogenesis and treatment of diabetic nephropathy. Nat Rev Nephrol 2010; 6(6): 319–330.
Google Scholar | Crossref | Medline20. Kume, S, Yamahara, K, Yasuda, M, et al. Autophagy: emerging therapeutic target for diabetic nephropathy. Semin Nephrol 2014; 34: 9–16.
Google Scholar | Crossref | Medline21. Takabatake, Y, Kimura, T, Takahashi, A, et al. Autophagy and the kidney: health and disease. Nephrol Dial Transplant 2014; 29: 1639–1647.
Google Scholar | Crossref | Medline22. Yang, D, Livingston, M, Liu, Z, et al. Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential. Cell Mol Life Sci 2018; 75: 669–688.
Google Scholar | Crossref | Medline23. Choi, AMK, Ryter, SW, Beth, L. Autophagy in human health and disease. N Engl J Med 2013; 368(7): 651–662.
Google Scholar | Crossref | Medline | ISI24. Glick, D, Barth, S, Macleod, KF. Autophagy: cellular and molecular mechanisms. J Pathol 2010; 221: 3–12.
Google Scholar | Crossref | Medline | ISI25. Yamahara, K, Yasuda, M, Kume, S, et al. The role of autophagy in the pathogenesis of diabetic nephropathy. J Diabetes Res 2013; 2013.
Google Scholar | Crossref | Medline26. Arakawa, S, Honda, S, Yamaguchi, H, et al. Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy. Proc Jpn Acad Ser B Phys Biol Sci 2017; 93: 378–385.
Google Scholar | Crossref | Medline27. Walczak, M, Martens, S. Dissecting the role of the Atg12-Atg5-Atg16 complex during autophagosome formation. Autophagy 2013; 9(3): 424–425.
Google Scholar | Crossref | Medline28. Qi, Z, Fujita, H, Jin, J, et al. Characterization of susceptibility of inbred mouse strains to diabetic nephropathy. Diabetes 2005; 54(9): 2628–2637.
Google Scholar | Crossref | Medline29. Alizadeh, S, Mazloom, H, Sadeghi, A, et al. Evidence for the link between defective autophagy and inflammation in peripheral blood mononuclear cells of type 2 diabetic patients. J Physiol Biochem 2018; 74(3): 369–379.
Google Scholar | Crossref | Medline30. Fang, L, Zhou, Y, Cao, H, et al. Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia induced podocyte injury. PLoS One 2013; 8(4): e60546
Google Scholar | Crossref | Medline | ISI31. Liu, W-J, Huang, W-F, Ye, L, et al. The activity and role of autophagy in the pathogenesis of diabetic nephropathy. Eur Rev Med Pharmacol Sci 2018; 22: 3182–3189.
Google Scholar | Medline32. Dong, D, Fan, TT, Ji, YH. Spironolactone alleviates diabetic nephropathy through promoting autophagy in podocytes. Int Urol Nephrol 2019; 51(4): 755–764.
Google Scholar | Crossref | Medline33. Warren, AM, Knudsen, ST, Cooper, ME. Diabetic nephropathy: an insight into molecular mechanisms and emerging therapies. Expert Opin Ther Targets 2019; 23(7): 579–591.
Google Scholar | Crossref | Medline34. Kitada, M, Ogura, Y, Monno, I, et al. Regulating autophagy as a therapeutic target for diabetic nephropathy. Curr Diab Rep 2017; 17.
Google Scholar | Crossref | Medline35. Bhattacharya, D, Mukhopadhyay, M, Bhattacharyya, M, et al. Is autophagy associated with diabetes mellitus and its complications? A review. EXCLI J 2018; 17: 709–720.
Google Scholar | Medline36. Dehdashtian, E, Mehrzadi, S, Yousefi, B, et al. Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin; involvement of autophagy, inflammation and oxidative stress. Life Sci 2018; 193: 20–33.
Google Scholar | Crossref | Medline