Available online 11 December 2021

Multicompartment drug delivery system.

Targeted carrier system for combination drug delivery.

Various preparation methods and modifications on lipids for effective targeting.

In this review, we discuss recent developments in multicompartment systems commonly referred to as vesosomes, as well as their method of preparation, surface modifications, and clinical potential. Vesosomal systems are able to entrap more than one drug moiety and can be customized for site-specific delivery. We focus in particular on the possible reticuloendothelial system (RES- mediated accumulation of vesosomes, and their application in tumor targeting, as areas for further investigation.

Multi-compartment system

Vesosomes

Liposome in liposome

PEGylation

Vesicular system

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