Combination therapy has shown great potential for effective cancer treatment. In this work, anticancer drug curcumin (Cur) and photothermal agent indocyanine green (ICG) have been encapsulated into the pH-responsive ZIF-8 simultaneously to obtain ICG&Cur@ZIF-8 through one-pot synthesis method. The drug loading capacity was estimated as 9.6 and 12.3 wt% for Cur and ICG, respectively. As expected, ICG&Cur@ZIF-8 exhibited the pH-responsive ICG and Cur delivery, which was ascribed to the decomposition of ZIF-8 in acidic environment. Moreover, ICG&Cur@ZIF-8 also showed the high photothermal performance due to the efficient encapsulation of ICG. The co-delivery of two therapeutic agents may bring more opportunities for biomedical application.