Z.R. Zhu, X.L. Zhang, L. Cheng and G.L. Tang

Author information

Department of Urology, Shaoxing People’s Hospital, Zhejiang University School of Medicine, Shaoxing, Zhejiang, China

Abstract

This study aimed at observing the expression of thioredoxin domain-containing protein 5 (TXNDC5) in the epididymis of rats with varicocele (VC) and the change after high ligation of the spermatic vein. Thirty-seven-week-old male SD rats were randomly divided into sham operation, varicocele model, and treatment group. The treatment alleviated damage in the epididymis tissue of the varicocele model and inhibited the increase of miR-200c induced by varicocele. In addition, the TXNDC5 protein level in the treatment group was significantly higher than that in the model group but still lower than that in the sham operation group. In conclusion, high ligation of varicocele could repair epididymal injury, decrease miR-200c and increase TXNDC5 in the epididymis.

Keywords:

NF-κB, PPAR-γ, inflammatory response, pogostone, traumatic brain injury (TBI)

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