The effects of atorvastatin on emotional processing, reward learning, verbal memory and inflammation in healthy volunteers: An experimental medicine study

Abbasi, SH, Mohammadinejad, P, Shahmansouri, N, et al. (2015) Simvastatin versus atorvastatin for improving mild to moderate depression in post-coronary artery bypass graft patients: A double-blind, placebo-controlled, randomized trial. Journal of Affective Disorders 183: 149–155.
Google Scholar | Crossref | Medline | ISI Anderson, NH (1968) Likableness ratings of 555 personality-trait words. Journal of Personality and Social Psychology 9: 272–279.
Google Scholar | Crossref | Medline | ISI Arnone, D, Horder, J, Cowen, PJ, et al. (2009) Early effects of mirtazapine on emotional processing. Psychopharmacology 203(4): 685–691.
Google Scholar | Crossref | Medline Attenburrow, MJ, Williams, C, Odontiadis, J, et al. (2003) Acute administration of nutritionally sourced tryptophan increases fear recognition. Psychopharmacology 169(1): 104–107.
Google Scholar | Crossref | Medline Beck, AT, Ward, CH, Mendelson, M, et al. (1961) An inventory for measuring depression. Archives of General Psychiatry 4: 561–571.
Google Scholar | Crossref | Medline Berk, M, Mohebbi, M, Dean, OM, et al. (2020) Youth depression alleviation with anti-inflammatory agents (YoDA-A): A randomised clinical trial of rosuvastatin and aspirin. BMC Medicine 18(1): 16.
Google Scholar | Crossref | Medline Bond, A, Lader, M (1974) The use of analogue scales in rating subjective feelings. British Journal of Medical Psychology 47: 211–218.
Google Scholar | Crossref | ISI Browning, M, Reid, C, Cowen, PJ, et al. (2007) A single dose of citalopram increases fear recognition in healthy subjects. Journal of Psychopharmacology 21(7): 684–690.
Google Scholar | SAGE Journals | ISI Burghardt, NS, Sullivan, GM, McEwen, BS, et al. (2004) The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: A comparison with tianeptine. Biological Psychiatry 55(12): 1171–1178.
Google Scholar | Crossref | Medline Chamberlain, SR, Cavanagh, J, de Boer, P, et al. (2019) Treatment-resistant depression and peripheral C-reactive protein. The British Journal of Psychiatry 214(1): 11–19.
Google Scholar | Crossref | Medline Chan, SY, Capitão, L, Probert, F, et al. (2020) A single administration of the antibiotic, minocycline, reduces fear processing and improves implicit learning in healthy volunteers: Analysis of the serum metabolome. Translational Psychiatry 10(1): 148.
Google Scholar | Crossref | Medline Chou, R, Dana, T, Blazina, I, et al. (2016) Statin Use for the Prevention of Cardiovascular Disease in Adults: A Systematic Review for the U.S. Preventive Services Task Force (Internet, Evidence Syntheses, No. 139. Table 1, Statin Dosing and ACC/AHA Classification of Intensity). Rockville, MD: Agency for Healthcare Research and Quality. Available at: https://www.ncbi.nlm.nih.gov/books/NBK396417/table/ch1.t1/
Google Scholar | Crossref Collins, R, Reith, C, Emberson, J, et al. (2016) Interpretation of the evidence for the efficacy and safety of statin therapy. The Lancet 388(10059): 2532–2561.
Google Scholar | Crossref | Medline Cooper, CM, Godlewska, B, Sharpley, AL, et al. (2018) Interferon-α induces negative biases in emotional processing in patients with hepatitis C virus infection: A preliminary study. Psychological Medicine 48(6): 998–1007.
Google Scholar | Crossref | Medline Corsini, A, Bellosta, S, Baetta, R, et al. (1999) New insights into the pharmacodynamic and pharmacokinetic properties of statins. Pharmacology & Therapeutics 84(3): 413–428.
Google Scholar | Crossref | Medline De Giorgi, R, De Crescenzo, F, Cowen, PJ (2021c) Effects of various statins on depressive symptoms: Is there enough evidence? Journal of Affective Disorders 295: 1093–1094.
Google Scholar | Crossref | Medline De Giorgi, R, De Crescenzo, F, Rizzo Pesci, N, et al. (2021b) Statins for major depressive disorder: A systematic review and meta-analysis of randomized controlled trials. PLoS ONE 16(3): e0249409.
Google Scholar | Crossref | Medline De Giorgi, R, Rizzo Pesci, N, Quinton, A, et al. (2021a) Statins in depression: An evidence-based overview of mechanisms and clinical studies. Frontiers in Psychiatry 12: 702617.
Google Scholar | Crossref | Medline Deakin, JFW, Graeff, FG (1991) 5-HT and mechanisms of defence. Journal of Psychopharmacology 5(4): 305–315.
Google Scholar | SAGE Journals Enache, D, Pariante, CM, Mondelli, V (2019) Markers of central inflammation in major depressive disorder: A systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue. Brain, Behavior, and Immunity 81: 24–40.
Google Scholar | Crossref | Medline Endo, A, Kuroda, M, Tanzawa, K (1976) Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity. FEBS Letters 72(2): 323–326.
Google Scholar | Crossref | Medline Eysenck, SBG, Eysenck, HJ, Barrett, P (1985) A revised version of the Psychoticism Scale. Personality and Individual Differences 6: 21–29.
Google Scholar | Crossref | ISI Faul, F, Erdfelder, E, Lang, AG, et al. (2007) G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods 39(2): 175–191.
Google Scholar | Crossref | Medline | ISI Felger, J, Treadway, M (2017) Inflammation effects on motivation and motor activity: Role of dopamine. Neuropsychopharmacol 42: 216–241.
Google Scholar | Crossref | Medline | ISI First, MB, Williams, JBW, Karg, RS, et al. (2016) User’s Guide for the SCID-5-CV Structured Clinical Interview for DSM-5® Disorders: Clinical Version. Washington, DC: American Psychiatric Publishing.
Google Scholar Godlewska, BR, Harmer, CJ (2021) Cognitive neuropsychological theory of antidepressant action: A modern-day approach to depression and its treatment. Psychopharmacology 238: 1265–1278.
Google Scholar | Crossref | Medline Grier, JB (1971) Nonparametric indexes for sensitivity and bias: Computing formulas. Psychological Bulletin 75(6): 424–429.
Google Scholar | Crossref | Medline Gulbins, E, Palmada, M, Reichel, M, et al. (2013) Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs. Nature Medicine 19(7): 934–938.
Google Scholar | Crossref | Medline Haghighi, M, Khodakarami, S, Jahangard, L, et al. (2014) In a randomized, double-blind clinical trial, adjuvant atorvastatin improved symptoms of depression and blood lipid values in patients suffering from severe major depressive disorder. Journal of Psychiatric Research 58: 109–114.
Google Scholar | Crossref | Medline | ISI Harmer, CJ, Cowen, PJ (2013) ‘It’s the way that you look at it’: A cognitive neuropsychological account of SSRI action in depression. Philosophical Transactions of the Royal Society B 368: 20120407.
Google Scholar | Crossref | Medline | ISI Harmer, CJ, Bhagwagar, Z, Perrett, DI, et al. (2003) Acute SSRI administration affects the processing of social cues in healthy volunteers. Neuropsychopharmacology 28(1): 148–152.
Google Scholar | Crossref | Medline Harmer, CJ, Cowen, PJ, Goodwin, GM (2011) Efficacy markers in depression. Journal of Psychopharmacology 25(9): 1148–1158.
Google Scholar | SAGE Journals | ISI Harmer, CJ, Duman, RS, Cowen, PJ (2017) How do antidepressants work? New perspectives for refining future treatment approaches. The Lancet Psychiatry 4(5): 409–418.
Google Scholar | Crossref | Medline Harmer, CJ, O’Sullivan, U, Favaron, E, et al. (2009) Effect of acute antidepressant administration on negative affective bias in depressed patients. The American Journal of Psychiatry 166(10): 1178–1184.
Google Scholar | Crossref | Medline | ISI Harmer, CJ, Shelley, NC, Cowen, PJ, et al. (2004) Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition. The American Journal of Psychiatry 161(7): 1256–1263.
Google Scholar | Crossref | Medline Horder, J, Browning, M, Di Simplicio, M, et al. (2012) Effects of 7 days of treatment with the cannabinoid type 1 receptor antagonist, rimonabant, on emotional processing. Journal of Psychopharmacology 26(1): 125–132.
Google Scholar | SAGE Journals | ISI Hudgins, LC, Parker, TS, Levine, DM, et al. (2003) A single intravenous dose of endotoxin rapidly alters serum lipoproteins and lipid transfer proteins in normal volunteers. Journal of Lipid Research 44(8): 1489–1498.
Google Scholar | Crossref | Medline Husain, MI, Chaudhry, IB, Khoso, AB, et al. (2019) Adjunctive simvastatin for treatment-resistant depression: Study protocol of a 12-week randomised controlled trial. BJPsych Open 5(1): e13.
Google Scholar | Crossref Husain, MI, Chaudhry, IB, Khoso, AB, et al. (2020) Minocycline and celecoxib as adjunctive treatments for bipolar depression: A multicentre, factorial design randomised controlled trial. The Lancet Psychiatry 7(6): 515–527.
Google Scholar | Crossref | Medline IBM (2020) IBM SPSS Statistics for Macintosh (Version 27.0, Released 2020). Armonk, NY: IBM.
Google Scholar Jain, MK, Ridker, PM (2005) Anti-inflammatory effects of statins: Clinical evidence and basic mechanisms. Nature Reviews Drug Discovery 4(12): 977–987
Google Scholar | Crossref | Medline | ISI Köhler-Forsberg, O, Otte, C, Gold, SM, et al. (2020) Statins in the treatment of depression: Hype or hope? Pharmacology & Therapeutics 215: 107625.
Google Scholar | Crossref | Medline Köhler, O, Gasse, C, Petersen, L, et al. (2016) The effect of concomitant treatment with SSRIs and statins: A population-based study. The American Journal of Psychiatry 173(8): 807–815.
Google Scholar | Crossref | Medline Law, MR, Wald, NJ, Rudnicka, AR (2003) Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: Systematic review and meta-analysis. The BMJ 326: 1423.
Google Scholar | Crossref | Medline Lee, LH, Shui, G, Farooqui, AA, et al. (2009) Lipidomic analyses of the mouse brain after antidepressant treatment: Evidence for endogenous release of long-chain fatty acids? The International Journal of Neuropsychopharmacology 12(7): 953–964.
Google Scholar | Crossref | Medline Lee, MC, Peng, TR, Chen, BL, et al. (2021) Effects of various statins on depressive symptoms: A network meta-analysis. Journal of Affective Disorders 293: 205–213.
Google Scholar | Crossref | Medline Lundqvist, ED, Flykt, A, Öhman, A (1998) The Karolinska Directed Emotional Faces (KDEF, CD ROM). Stockholm: Psychology Section, Department of Clinical Neuroscience, Karolinska Institutet.
Google Scholar McFarland, AJ, Anoopkumar-Dukie, S, Arora, DS, et al. (2014) Molecular mechanisms underlying the effects of statins in the central nervous system. International Journal of Molecular Sciences 15(11): 20607–20637.
Google Scholar | Crossref | Medline Macin, SM, Perna, ER, Farías, EF, et al. (2005) Atorvastatin has an important acute anti-inflammatory effect in patients with acute coronary syndrome: Results of a randomized, double-blind, placebo-controlled study. American Heart Journal 149(3): 451–457.
Google Scholar | Crossref | Medline McInt

留言 (0)

沒有登入
gif