Améndola, L, Weary, DM (2020) Understanding rat emotional responses to CO2. Translational Psychiatry 10: 253.
Google Scholar | Crossref | Medline American Psychiatric Association (APA) (2013) Diagnostic and Statistical Manual of Mental Disorders (5th edn). Washington, DC: APA.
Google Scholar | Crossref Baratta, MV, Leslie, NR, Fallon, IP, et al. (2018) Behavioural and neural sequelae of stressor exposure are not modulated by controllability in females. European Journal of Neuroscience 47: 959–967.
Google Scholar | Crossref | Medline Beck, JG, Ohtake, PJ, Shipherd, JC (1999) Exaggerated anxiety is not unique to CO2 in panic disorder: A comparison of hypercapnic and hypoxic challenges. Journal of Abnormal Psychology 108: 473–482.
Google Scholar | Crossref | Medline | ISI Brack, KE, Lovick, TA (2007) Neuronal excitability in the periaqueductal grey matter during the estrous cycle in female Wistar rats. Neuroscience 144: 325–335.
Google Scholar | Crossref | Medline | ISI Brack, KE, Jeffery, SM, Lovick, TA (2006) Cardiovascular and respiratory responses to a panicogenic agent in anaesthetised female Wistar rats at different stages of the oestrous cycle. European Journal of Neuroscience 23: 3309–3318.
Google Scholar | Crossref | Medline | ISI Broiz, AC, Bassi, GS, De Souza Silva, MA, et al. (2012) Effects of neurokinin-1 and 3-receptor antagonists on the defensive behavior induced by electrical stimulation of the dorsal periaqueductal gray. Neuroscience 201: 134–145.
Google Scholar | Crossref | Medline Butcher, RL, Collins, WE, Fugo, NW (1974) Plasma concentration of LH, FSH, prolactin, progesterone and estradiol-17beta throughout the 4-day estrous cycle of the rat. Endocrinology 94: 1704–1708.
Google Scholar | Crossref | Medline | ISI Calizo, LH, Akanwa, A, Ma, X, et al. (2011) Raphe serotonin neurons are not homogenous: Electrophysiological, morphological and neurochemical evidence. Neuropharmacology 61: 524–543.
Google Scholar | Crossref | Medline | ISI Christiansen, DM (2015) Examining sex and gender differences in anxiety disorders. In: Durbano, F (ed.) A Fresh Look at Anxiety Disorders: 17–50. London: In TechOpen.
Google Scholar | Crossref Commons, KG, Valentino, RJ (2002) Cellular basis for the effects of substance P in the periaqueductal gray and dorsal raphe nucleus. Journal of Comparative Neurology 447: 82–97.
Google Scholar | Crossref | Medline | ISI Day, HE, Greenwood, BN, Hammack, SE, et al. (2004) Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus. Journal of Comparative Neurology 474: 364–378.
Google Scholar | Crossref | Medline | ISI Devall, AJ, Liu, ZW, Lovick, TA (2009) Hyperalgesia in the setting of anxiety: Sex differences and effects of the oestrous cycle in Wistar rats. Psychoneuroendocrinology 34: 5875–5896.
Google Scholar | Crossref Devall, AJ, Santos, JM, Fry, JP, et al. (2015) Elevation of brain allopregnanolone rather than 5-HT release by short term, low dose fluoxetine treatment prevents the estrous cycle-linked increase in stress sensitivity in female rats. European Neuropsychopharmacology 25: 113–123.
Google Scholar | Crossref | Medline | ISI Díaz-Véliz, G, Alarcón, T, Espinoza, C, et al. (1997) Ketanserin and anxiety levels: Influence of gender, estrous cycle, ovariectomy and ovarian hormones in female rats. Pharmacology, Biochemistry, and Behavior 58: 637–642.
Google Scholar | Crossref | Medline | ISI Eaton, WW, Kessler, RC, Wittchen, HU, et al. (1994) Panic and panic disorder in the United States. American Journal of Psychiatry 151: 413–420.
Google Scholar | Crossref | Medline | ISI Fernandes, GG, Frias, AT, Spiacci, A, et al. (2019) Nitric oxide in the dorsal periaqueductal gray mediates the panic-like escape response evoked by exposure to hypoxia. Progress in Neuro-Psychopharmacology & Biological Psychiatry 92: 321–327.
Google Scholar | Crossref | Medline Fox, JH, Lowry, CA (2013) Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior. Frontiers in Neuroscience 7: 169.
Google Scholar | Crossref | Medline Fry, JP, Li, KY, Devall, AJ, et al. (2014) Fluoxetine elevates allopregnanolone in female rat brain but inhibits a steroid microsomal dehydrogenase rather than activating an aldo-keto reductase. British Journal of Pharmacology 171: 5870–5880.
Google Scholar | Crossref | Medline | ISI Frye, CA, Petralia, SM, Rhodes, ME (2000) Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3alpha,5alpha-THP. Pharmacology, Biochemistry, and Behavior 67: 587–596.
Google Scholar | Crossref | Medline | ISI Fu, W, Le Maître, E, Fabre, V, et al. (2010) Chemical neuroanatomy of the dorsal raphe nucleus and adjacent structures of the mouse brain. Journal of Comparative Neurology 518: 3464–3494.
Google Scholar | Crossref | Medline | ISI Gervasoni, D, Peryon, C, Rampon, C, et al. (2000) Role and origin of the GABAergic innervation of dorsal raphe serotonergic neurons. Journal of Neuroscience 20: 4217–4225.
Google Scholar | Crossref | Medline | ISI Gouveia, A, dos Santos, UD, Felisbino, FE, et al. (2004) Influence of the estrous cycle on the behavior of rats in the elevated T-maze. Behavioural Processes 67: 167–171.
Google Scholar | Crossref | Medline Griffiths, JL, Lovick, TA (2005) GABAergic neurones in the rat periaqueductal grey matter express alpha4, beta1 and delta GABAA receptor subunits: Plasticity of expression during the estrous cycle. Neuroscience 136: 457–466.
Google Scholar | Crossref | Medline | ISI Guo, X, Meng, Z, Huang, G, et al. (2016) Meta-analysis of the prevalence of anxiety disorders in mainland China from 2000 to 2015. Scientific Report 6: 292–300.
Google Scholar Hajós, M, Hoffmann, WE, Tetko, IV, et al. (2001) Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT1A receptors. Neuroscience Letters 304: 129–132.
Google Scholar | Crossref | Medline | ISI Hale, MW, Shekhar, A, Lowry, CA (2012) Stress-related serotonergic systems: Implications for symptomatology of anxiety and affective disorders. Cellular and Molecular Neurobiology 32: 695–708.
Google Scholar | Crossref | Medline | ISI Hervás, I, Artigas, F (1998) Effect of fluoxetine on extracellular 5-hydroxytryptamine in rat brain. Role of 5-HT autoreceptors. European Journal of Pharmacology 358: 9–18.
Google Scholar | Crossref | Medline Johnson, PL, Federici, LM, Shekhar, A (2014) Etiology, triggers and neurochemical circuits associated with unexpected, expected, and laboratory- induced panic attacks. Neuroscience & Biobehavioral Reviews 3: 429–454.
Google Scholar | Crossref Johnson, PL, Fitz, SD, Hollis, JH, et al. (2011) Induction of c-Fos in “panic/defence”-related brain circuits following brief hypercarbic gas exposure. Journal of Psychopharmacology 25: 26–36.
Google Scholar | SAGE Journals | ISI Johnson, PL, Hollis, JH, Moratalla, R, et al. (2005) Acute hypercarbic gas exposure reveals functionally distinct subpopulations of serotonergic neurons in rats. Journal of Psychopharmacology 19: 327–341.
Google Scholar | SAGE Journals | ISI Joyce, PR, Bushnell, JA, Oakley-Browne, MA, et al. (1989) The epidemiology of panic symptomatology and agoraphobic avoidance. Comprehensive Psychiatry 30: 303–312.
Google Scholar | Crossref | Medline | ISI Kirby, LG, Allen, AR, Lucki, I (1995) Regional differences in the effects of forced swimming on extracellular levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. Brain Research 682: 189–196.
Google Scholar | Crossref | Medline Kirby, LG, Lucki, I (1997) Interaction between the forced swimming test and fluoxetine treatment on extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the rat. Journal of Pharmacology and Experimental Therapeutics 282: 967–976.
Google Scholar | Medline Kovács, KJ (2008) Measurement of immediate-early gene activation- c-fos and beyond. Journal of Neuroendocrinology 20: 665–672.
Google Scholar | Crossref | Medline | ISI Kramer, JM, Nolan, PC, Waldrop, TG (1999) In vitro responses of neurons in the periaqueductal gray to hypoxia and hypercapnia. Brain Research 835: 197–203.
Google Scholar | Crossref | Medline Lopes, DA, Lemes, JA, Melo -Thomas, L, et al. (2016) Unpredictable chronic mild stress exerts anxiogenic-like effects and activates neurons in the dorsal and caudal region and in the lateral wings of the dorsal raphe nucleus. Behavioural Brain Research 297: 180–186.
Google Scholar | Crossref | Medline Lovick, TA (2014) Sex determinants of experimental panic attacks. Neuroscience & Biobehavioral Reviews 46: 465–471.
Google Scholar | Crossref | Medline Machado-Figueiredo, R, de Carvalho, MC, Brandão, ML, et al. (2019) Short-term, low-dose fluoxetine prevents oestrous cycle-linked increase in anxiety-like behaviour in female rats. Journal of Psychopharmacology 33: 548–557.
Google Scholar | SAGE Journals McLean, CP, Asnaani, A, Litz, BT, et al. (2011) Gender differences in anxiety disorders: Prevalence, course of illness, comorbidity and burden of illness. Journal of Psychiatric Research 45: 1027–1035.
Google Scholar | Crossref | Medline | ISI Marques, DA, de Carvalho, D, da Silva, GSF, et al. (2017) Influence of estrous cycle hormonal fluctuations and gonadal hormones on the ventilatory response to hypoxia in female rats. Pflugers Archiv 469: 1277–1286.
Google Scholar | Crossref | Medline Niccolai, V, van Duinen, MA, Griez, EJ (2009) Respiratory patterns in panic disorder reviewed: A focus on biological challenge tests. Acta Psychiatrica Scandinavica 120: 167–177.
Google Scholar | Crossref | Medline | ISI Nillni, YI, Pineles, SL, Rohan, KJ, et al. (2017) The influence of the menstrual cycle on reactivity to a CO2 challenge among women with and without premenstrual symptoms. Cognitive Behaviour Therapy 3: 239–249.
Google Scholar Nillni, YI, Rohan, KJ, Zvolensky, MJ (2012) The role of menstrual cycle phase and anxiety sensitivity in catastrophic misinterpretation of physical symptoms during a CO2 challenge. Archives of Women’s Mental Health 15: 413–422.
Google Scholar | Crossref | Medline | ISI Paul, ED, Lowry, CA (2013) Functional topography of serotonergic systems supports the Deakin/Graeff hypothesis of anxiety and affective disorders. Journal of Psychopharmacology 27: 1090–1106.
Google Scholar | SAGE Journals | ISI Paul, ED, Johnson, PL, Shekhar, A, et al. (2014) The Deakin/Graeff hypothesis: Focus on serotonergic inhibition of panic. Neuroscience & Biobehavioral Reviews 3: 379–396.
Google Scholar | Crossref Paxinos, G, Watson, C (1998) The Rat Brain in Stereotaxic Coordinates (4th edn). San Diego, CA: Academic Press.
Google Scholar Pinna, G, Costa, E, Guidotti, A (2004) Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids. Proceedings of the National Academy of Sciences of the United States of America 101: