Elevated ectodomain of type 23 collagen is a novel biomarker of the intestinal epithelium to monitor disease activity in ulcerative colitis and Crohn’s disease

1. Bischoff, SC, Barbara, G, Buurman, W, et al. Intestinal permeability – a new target for disease prevention and therapy. BMC Gastroenterol 2014; 14: 189–214.
Google Scholar | Crossref | Medline2. Groschwitz, KR, Hogan, SP. Intestinal barrier function: molecular regulation and disease pathogenesis. J Allergy Clin Immunol 2009; 124: 3–20; quiz 21–22.
Google Scholar | Crossref | Medline | ISI3. Giuffrida, P, Corazza, GR, Di Sabatino, A, Old and new lymphocyte players in inflammatory bowel disease. Dig Dis Sci 2018; 63: 277–288.
Google Scholar | Crossref | Medline4. Chang, J, Leong, RW, Wasinger, VC, et al. Impaired intestinal permeability contributes to ongoing bowel symptoms in patients with inflammatory bowel disease and mucosal healing. Gastroenterology 2017; 153: 723–731.e1.
Google Scholar | Crossref | Medline5. Banyard, J, Bao, L, Zetter, BR. Type XXIII collagen, a new transmembrane collagen identified in metastatic tumor cells. J Biol Chem 2003; 278: 20989–20994.
Google Scholar | Crossref | Medline6. Veit, G, Zimina, EP, Franzke, CW, et al. Shedding of collagen XXIII is mediated by furin and depends on the plasma membrane microenvironment. J Biol Chem 2007; 282: 27424–27435.
Google Scholar | Crossref | Medline7. Gassler, N, Rohr, C, Schneider, A, et al. Inflammatory bowel disease is associated with changes of enterocytic junctions. Am J Physiol Gastrointest Liver Physiol 2001; 281: G216–G228.
Google Scholar | Crossref | Medline8. Ohta, H, Sunden, Y, Yokoyama, N, et al. Expression of apical junction complex proteins in duodenal mucosa of dogs with inflammatory bowel disease. Am J Vet Res 2014; 75: 746–751.
Google Scholar | Crossref | Medline | ISI9. Karayiannakis, AJ, Syrigos, KN, Efstathiou, J, et al. Expression of catenins and E-cadherin during epithelial restitution in inflammatory bowel disease. J Pathol 1998; 185: 413–418.
Google Scholar | Crossref | Medline10. Dogan, A, Wang, ZD, Spencer, J. E-cadherin expression in intestinal epithelium. J Clin Pathol 1995; 48: 143–146.
Google Scholar | Crossref | Medline | ISI11. Mortensen, JH, Godskesen, LE, Jensen, MD, et al. Fragments of citrullinated and MMP-degraded vimentin and MMP-degraded type III collagen are novel serological biomarkers to differentiate Crohn’s disease from ulcerative colitis. J Crohn’s Colitis 2015; 9: 863–872.
Google Scholar | Crossref | Medline12. van Haaften, WT, Mortensen, JH, Karsdal, MA, et al. Misbalance in type III collagen formation/degradation as a novel serological biomarker for penetrating (Montreal B3) Crohn’s disease. Aliment Pharmacol Ther 2017; 14: 26–39.
Google Scholar | Crossref13. Mortensen, JH, Manon-Jensen, T, Jensen, MD, et al. Ulcerative colitis, Crohn’s disease, and irritable bowel syndrome have different profiles of extracellular matrix turnover, which also reflects disease activity in Crohn’s disease. PLoS One 2017; 12: 1–16.
Google Scholar | Crossref14. Lindholm, M, Manon-Jensen, T, Madsen, GI, et al. Extracellular matrix fragments of the basement membrane and the interstitial matrix are serological markers of intestinal tissue remodeling and disease activity in dextran sulfate sodium colitis. Dig Dis Sci 2019; 64: 3134–3142.
Google Scholar | Crossref | Medline15. Mortensen, JH, Lindholm, M, Langholm, LL, et al. The intestinal tissue homeostasis – the role of extracellular matrix remodeling in inflammatory bowel disease. Expert Rev Gastroenterol Hepatol 2019; 13: 977–993.
Google Scholar | Crossref | Medline16. Shimshoni, E, Yablecovitch, D, Baram, L, et al. ECM remodelling in IBD: Innocent bystander or partner in crime? The emerging role of extracellular molecular events in sustaining intestinal inflammation. Gut 2015; 64: 367–372.
Google Scholar | Crossref | Medline17. Ravi, A, Garg, P, Sitaraman, SV. Matrix metalloproteinases in inflammatory bowel disease: boon or a bane? Inflamm Bowel Dis 2007; 13: 97–107.
Google Scholar | Crossref | Medline18. Petrey, AC, De La Motte, CA. The extracellular matrix in IBD: a dynamic mediator of inflammation. Curr Opin Gastroenterol 2017; 33: 234–238.
Google Scholar | Crossref | Medline19. Giuffrida, P, Biancheri, P, Macdonald, TT. Proteases and small intestinal barrier function in health and disease. Curr Opin Gastroenterol 2014; 30: 147–153.
Google Scholar | Crossref | Medline20. Jensen, C, Nielsen, SH, Mortensen, JH, et al. Serum type XVI collagen is associated with colorectal cancer and ulcerative colitis indicating a pathological role in gastrointestinal disorders. Cancer Med 2018; 7: 4619–4626.
Google Scholar | Crossref | Medline21. Holm Nielsen, S, Mortensen, JH, Willumsen, N, et al. A fragment of collagen type VI alpha-3 chain is elevated in serum from patients with gastrointestinal disorders. Sci Rep 2020; 10: 1–9.
Google Scholar | Crossref | Medline22. Spivey, KA, Chung, I, Banyard, J, et al. A role for collagen XXIII in cancer cell adhesion, anchorage-independence and metastasis. Oncogene 2012; 31: 2362–2372.
Google Scholar | Crossref | Medline23. Xu, F, Chang, K, Ma, J, et al. The oncogenic role of COL23A1 in clear cell renal cell carcinoma. Sci Rep 2017; 7: 9846.
Google Scholar | Crossref | Medline24. D’Incà, R, Di Leo, V, Corrao, G, et al. Intestinal permeability test as a predictor of clinical course in Crohn’s disease. Am J Gastroenterol 1999; 94: 2956–2960.
Google Scholar | Crossref | Medline | ISI25. Mortensen, JH, van Haaften, WT, Karsdal, MA, et al. The citrullinated and MMP-degraded vimentin biomarker (VICM) predicts early response to anti-TNFα treatment in Crohn’s disease. J Clin Gastroenterol 2020; 55: 59–66. DOI:10.1097/MCG.0000000000001341.
Google Scholar26. D’Haens, G, Ferrante, M, Vermeire, S, et al. Fecal calprotectin is a surrogate marker for endoscopic lesions in inflammatory bowel disease. Inflamm Bowel Dis 2012; 18: 2218–2224.
Google Scholar | Crossref | Medline | ISI27. Karsdal, MA, Leeming, DJ, Heniksen, K, et al. Biochemistry of collagens, laminins and elastin: structure, function and biomarkers. 2nd ed. London: Elsevier Inc., 2019.
Google Scholar

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