Introduction

Medicinal plants and their derived products remain as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery. There are several advantages for plant-derived therapeutics including wide availability, diverse pharmacological actions and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying to the efficacy and safety of medicinal plants and phytochemicals in ameliorating several human diseases. A plethora of basic studies has also unravelled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products and drug interactions remain to be further studied. In this book, we aim to put together several chapters on the medicinal properties and pharmacological action of medicinal plants, plant species and phytochemicals. The goal of this contributed volume is to present a comprehensive collection on most important therapeutic aspects of plant-derived natural products and their molecular mechanisms of action.

Keywords

Curcumin Pharmacology Phytomedicine Complementary therapy Turmeric

Editors and affiliations

George E. BarretoAmirhossein Sahebkar1.Department of Biological SciencesUniversity of LimerickLimerickIreland2.Applied Biomedical Research CenterMashhad University of Medical SciencesMashhadIran About the editors George E. Barreto earned his PhD in Neuroscience (2009) from Universidad Complutense Madrid (Spain) studying the effects of neurosteroids on reactive glia with aging. His post-doctoral training at Stanford University School of Medicine (2009-2011) focused on addressing the role of astrocytes activation following stroke and enhance astrocytic functions targeting neuronal protection. Dr. Barreto is currently a Lecturer in Cell Biology/Immunology at University of Limerick, Ireland. His research interests focus on deciphering the neuropathological mechanisms induced by accumulation of lipids in glial cells, identifying different mechanisms by which hormones can affect brain lipid metabolism and how lipids accumulation can induce neuroinflammation in absence of brain-synthesized estradiol. He is also interested in immune and neuroendocrine aspects of glial cells as a pathological mechanism in many neurological diseases. He has published over 200 peer-reviewed manuscripts, 12 book chapters, and participated as speaker in several international congresses/meetings.

Amirhossein Sahebkar received her Pharm.D and PhD (in Pharmaceutical Biotechnology) degrees from the Mashhad University of Medical Sciences (MUMS; Mashhad, Iran), and is currently serving as a faculty member at the Department of Medical Biotechnology (School of Medicine), and Biotechnology Research Center of MUMS, with an adjunct title at the Metabolic Research Centre, University of Western Australia (Perth, Australia). His research focuses on the investigation of novel lipid-modifying agents, including natural products, for the management of severe dyslipidemias (including familial hypercholesterolemia) and atherosclerotic cardiovascular disease. He has published over 800 publications on peer-reviewed international scientific journals, wrote several books and book chapters and presented numerous communications in international and national congresses. He is among ESI-listed top 1% of the world highly cited researchers in two fields: Pharmacology & Toxicology and Clinical Medicine. He is also a member of several national and international scientific committees and organizations.

Bibliographic information Book Title Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health Editors George E. Barreto
Amirhossein Sahebkar
Series Title Advances in Experimental Medicine and Biology Series Abbreviated Title Adv Exp Med Biol DOI https://doi.org/10.1007/978-3-030-64872-5 Copyright Information Springer Nature Switzerland AG 2021 Publisher Name Springer, Cham eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0) Hardcover ISBN 978-3-030-64871-8 Softcover ISBN 978-3-030-64874-9 eBook ISBN 978-3-030-64872-5 Series ISSN 0065-2598 Series E-ISSN 2214-8019 Edition Number 1 Number of Pages X, 603 Number of Illustrations 786 b/w illustrations, 28 illustrations in colour Topics Pharmacology/Toxicology
Human Physiology
Biomedical Engineering/Biotechnology
Molecular Medicine