Chromatin Regulation of Early Embryonic Lineage Specification

Introduction

Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages. 

Keywords

extraembryonic primitive endoderm pluripotent epiblast embryonic chromatin structure CHD1 CHD4 H3R26me SOX2-DNA

Editors and affiliations

Jason KnottKeith Latham1.Department of Animal ScienceMichigan State UniversityEast LansingUSA2.Department of Animal ScienceMichigan State UniversityEast LansingUSA About the editors Dr. Jason Knott is a reproductive and developmental biologist with fifteen years of experience in mammalian embryology and stem cell biology. His research program is focused on elucidating chromatin based mechanisms that regulate gene expression programs and cell-fate determination in preimplantation embryos and embryonic stem cells. His current research focus is on understanding transcriptional and epigenetic mechanisms that govern cell polarity, pluripotency, trophoblast lineage formation, and trophoblast lineage differentiation in mice, humans, and cattle. 

Dr. Keith Latham is a developmental biologist with nearly three decades of experience in mammalian embryology.  His research encompasses epigenetics and imprinting in the early embryo, transcriptional control, translational control, determinants of oocyte quality, and mechanisms underlying meiotic spindle formation and function.  His research combines the use of diver

se mouse strains, molecular assays applicable to the single cell level, and embryo micromanipulation including different forms of nuclear transfer.
Bibliographic information Book Title Chromatin Regulation of Early Embryonic Lineage Specification Editors Jason Knott
Keith Latham
Series Title Advances in Anatomy, Embryology and Cell Biology Series Abbreviated Title Advs Anatomy DOI https://doi.org/10.1007/978-3-319-63187-5 Copyright Information Springer International Publishing AG 2018 Publisher Name Springer, Cham eBook Packages Medicine Medicine (R0) Softcover ISBN 978-3-319-63186-8 eBook ISBN 978-3-319-63187-5 Series ISSN 0301-5556 Series E-ISSN 2192-7065 Edition Number 1 Number of Pages VII, 78 Number of Illustrations 0 b/w illustrations, 16 illustrations in colour Topics Human Genetics
Cell Biology
Human Physiology

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