Comparison of new formulas of stannous fluoride toothpastes with other commercially available fluoridated toothpastes: A systematic review and meta‐analysis of randomised controlled trials

Lorenz, 20199 Single centre, RCT, double-blind clinical study 12 weeks

120 (amine fluoride and stannous chloride)

117 (monofluorophosphate)

Amine fluoride and stannous chloride versus monofluorophosphate PI, GI, mSBI, safety “…application of amine fluoride/stannous chloride toothpaste led to a clinically meaningful and more pronounced plaque reduction.” Yes Singh, 201810 RCT, double-blinded 6 weeks

24 (stannous fluoride and whitening gel)

25 (NaMFP)

Stannous fluoride and whitening gel versus NaMFP DPIA “the two-step dentifrice and gel sequence differed significantly (P < 0.005) from baseline on daytime plaque coverage, and salivary flow increased significantly (P = 0.033) ..” Yes Parkinson, 2018 31:81−8511 Single centre, examiner blind, two treatment arm parallel group RCT 12 weeks

119 (0.454% stannous fluoride)

119 (sodium monofluorophosphate)

0.454% stannous fluoride versus sodium monofluorophosphate MGI, blood in expectorate, BI “Statistically significant differences between treatments were observed in favour of the test [stannous fluoride] dentifrice compared with the negative control dentifrice in terms of gingival bleeding … and gingival inflammation (MGI) (P < 0.0001 at weeks 4 and 12 for all).” Yes Parkinson, 201512 RCT, examiner-blind, parallel, two treatment group 8 weeks

59 (0.454% stannous fluoride)

(59) sodium monofluorophosphate

0.454% stannous fluoride versus sodium monofluorophosphate Schiff score, tactile threshold, VAS “.. the test dentifrice [stannous fluoride] to be significantly better than the negative control dentifrice in relieving dentin hypersensitivity or all measures …” Yes Hu, 201913 RCT, examiner-blind 24 weeks

49 (0.454% stannous fluoride)

49 (0.76% sodium monofluorophosphate)

0.454% stannous fluoride versus 0.76% sodium monofluorophosphate GI, PI, GS, Gint, Pint “the test dentifrice [stannous fluoride) showed statistically significant reductions in all indexes compared with the control dentifrice (P < 0.001)” Yes Haraszthy, 201914 RCT, single site, double-blind, 2 treatment, parallel design 8 weeks

62 (stannous fluoride)

67 (sodium monofluorophosphate)

O.454% stannous fluoride versus sodium monofluorophosphate Bacterial reduction “the stannous fluoride toothpaste provided bacterial reductions in all oral microenvironments 12 h after brushing ..” Yes Hagenfield, 201915 RCT, double-blind, two centre study 12 weeks

21 (stannous fluoride)

20 (sodium monofluorophosphate)

Amine fluoride/stannous fluoride versus zinc-substituted carbonated hydroxyapatite Bacterial community level “The use of a toothpaste containing anti-adhesive HA did not induce statistically noticeably different changes on microbial composition ..” Yes Geidel, 201716 RCT, single-blind 24 weeks

25 (herbal toothpaste)

26 (triclosan toothpaste)

25 (stannous fluoride toothpaste)

Herbal toothpaste versus triclosan toothpaste versus stannous fluoride toothpaste OHI, API, SBI, BOP, PD, AL “the herbal toothpaste was as a good as the control toothpaste” Yes He, 2017; 28 (Spec Iss B): B12−16)17 Single centre, RCT, double-blind, parallel group 8 weeks

100 (0.454% stannous fluoride)

100 (0.30% triclosan toothpaste)

0.454% stannous fluoride versus 0.30% triclosan toothpaste MGI, GBI, number of bleeding sites “… the stannous fluoride dentifrice group showed statistically significant lower mean MGI and GBI scores than the subjects using the triclosan positive control dentifrice ..” Yes Gerlach, 201818 3 RCT (1 crossover, 2 parallel) Variable Unclear 0.454% stannous fluoride plus hydrogen peroxide versus 0.76% monofluorophosphate Malodour, plaque, bleeding sites “Relative to baseline, only the experimental group (0.454% stannous fluoride plus hydrogen peroxide) exhibited significant (P < 0.05) improvements at initial and subsequent timepoints in each trial.” Yes Milleman, 201819 Single centre, randomised, examiner-blind, two treatment arm parallel group study 24 weeks

108 (0.454% stannous fluoride toothpaste)

106 (0.76% sodium monofluorophosphate)

0.454% stannous fluoride toothpaste versus 0.76% sodium monofluorophosphate Lobene stain index, oral tolerability “Statistically significantly less anterior tooth staining was observed with up to 24 weeks twice daily brushing with a 0.454% SnF2/5% STP anhydrous dentifrice …” Yes Friesen, 201720 Single centre, RCT, double-blind, parallel group 4 weeks

60 (0.454% stannous fluoride toothpaste sodium)

60 (fluoride/triclosan toothpaste)

0.454% stannous fluoride toothpaste versus sodium fluoride/triclosan toothpaste RMNPI “The stabilised stannous fluoride dentifrice provided statistically significant reductions in plaque glycolysis in vitro and plaque growth in vivo compared with the triclosan dentifrice.” Yes Parkinson, 201621 3 RCT, examiner-blind, two treatment arm parallel group studies 2 weeks 113−120 subjects NaF toothpaste versus 0.454% stannous fluoride toothpaste versus 0.76% sodium monofluorophosphate Schiff sensitivity scale, VAS, tactile stimulus “While these studies provide evidence for relief of DH with 0.454% stannous fluoride dentifrices after short term use … the evidence, especially at the earliest time points, is inconclusive and needs further testing.” Yes Parkinson, 2018 31: 17−2322 RCT, single centre, examiner-blinded, two treatment arm parallel group 24 weeks

49 (0.454% stannous fluoride toothpaste)

49 (sodium monofluorophosphate toothpaste)

0.454% stannous fluoride toothpaste versus sodium monofluorophosphate toothpaste BI, MGI, PI “Use of a dentifrice containing 0.454% w/w stannous fluoride led to significantly greater control of gingivitis … and plaque compared with a SMFP dentifrice over a 24-week period.” Yes Seriwatanachai, 201923 RCT, single centre, double-blind, parallel group 24 weeks

45 (0.454% stannous stabilised zinc phosphate)

45 (0.454% stannous stabilised sodium hexametaphosphate)

45 (0.76% sodium monofluorophosphate)

0.454% stannous stabilised zinc phosphate versus 0.454% stannous stabilised sodium hexametaphosphate versus 0.76% sodium monofluorophosphate GI, PI, GS, PS, Gint, Pint “This study reports similar efficacy of a test dentifrice compared with a commercial SnF2 containing dentifrice for plaque control and reduction of gingival inflammation, and provides supporting evidence that the test dentifrice maintains its clinical efficacy with change of formulation.” Yes He, 2017; 28(Spec Iss B): B21−2624 RCT, double-blind, parallel group 8 weeks

41 (0.454% stannous fluoride toothpaste)

39 (NaF toothpaste)

0.454% stannous fluoride toothpaste versus NaF toothpaste Calculus “The stannous fluoride toothpaste had 15.1% less adjusted mean calculus at week 6 compared with the control group (P = 0.05)” Yes

留言 (0)

沒有登入
gif