Do Antibiotics Cause Obesity Through Long-term Alterations in the Gut Microbiome? A Review of Current Evidence

1.

NCD Risk Factor Collaboration. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet. 2017;390:2627–42. https://doi.org/10.1016/S0140-6736(17)32129-3.

Article  Google Scholar 

2.

Hales CM, Carroll MD, Fryar CD, Ogden CL. Prevalence of obesity and severe obesity among adults: United States. NCHS Data Brief, no 360. Hyattsville, MD: National Center for Health Statistics; 2017–2018. p. 2020.

Google Scholar 

3.

https://www.who.int/health-topics/obesity. Accessed on December 20, 2020

4.

Nishtar S, Gluckman P, Armstrong T. Ending childhood obesity: a time for action. Lancet. 2016;387(10021):825–7. https://doi.org/10.1016/S0140-6736(16)00140-9.4.

Article  PubMed  Google Scholar 

5.

Tsigalou C, Stavropoulou E, Bezirtzoglou E. Current insights in microbiome shifts in Sjogren's syndrome and possible therapeutic interventions. Front Immunol. 2018;9:1106. https://doi.org/10.3389/fimmu.2018.01106.

CAS  Article  PubMed  PubMed Central  Google Scholar 

6.

Thursby E, Juge N. Introduction to the human gut microbiota. Biochem J. 2017;474(11):1823–36. https://doi.org/10.1042/BCJ20160510.

CAS  Article  PubMed  Google Scholar 

7.

Rinninella E, Cintoni M, Raoul P, Lopetuso LR, Scaldaferri F, Pulcini G, et al. Food components and dietary habits: keys for a healthy gut microbiota composition. Nutrients. 2019;11(10):2393. https://doi.org/10.3390/nu11102393.

CAS  Article  PubMed Central  Google Scholar 

8.

Grivennikov S, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012;491(7423):254–8. https://doi.org/10.1038/nature11465.

CAS  Article  PubMed  PubMed Central  Google Scholar 

9.

Rea D, Coppola G, Palma G, Barbieri A, Luciano A, del Prete P, et al. Microbiota effects on cancer: from risks to therapies. Oncotarget. 2018;9(25):17915–27. https://doi.org/10.18632/oncotarget.24681.

Article  PubMed  PubMed Central  Google Scholar 

10.

Schwabe RF, Jobin C. The microbiome and cancer. Nat Rev Cancer. 2013;13(11):800–12. https://doi.org/10.1038/nrc3610.

CAS  Article  PubMed  PubMed Central  Google Scholar 

11.

Abreu MT, Peek RM. Gastrointestinal malignancy and the microbiome. Gastroenterology. 2014, 146(6):1534–1546.e3. https://doi.org/10.1053/j.gastro.2014.01.001.

12.

Vallianou NG, Tzortzatou-Stathopoulou F. Microbiota and cancer: an update. J Chemother. 2019;31(2):59–63. https://doi.org/10.1080/1120009X.2018.1541046.

CAS  Article  PubMed  Google Scholar 

13.

Vallianou N, Stratigou T, Christodoulatos GS, Dalamaga M. Understanding the role of the gut microbiome and microbial metabolites in obesity and obesity-associated metabolic disorders: current evidence and perspectives. Curr Obes Rep. 2019;8(3):317–32. https://doi.org/10.1007/s13679-019-00352-2.

Article  PubMed  Google Scholar 

14.

Rinninela E, Raoul P, Cintoni M, Franceschi F, Miggiano GAD, Gasparrini A, et al. What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases. Microorganisms. 2019;7(1):14. https://doi.org/10.3390/microorganisms7010014.

CAS  Article  Google Scholar 

15.

Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M, et al. Human gut microbiome viewed across age and geography. Nature. 2012;486(7402):222–7. https://doi.org/10.1038/nature11053.

CAS  Article  PubMed  PubMed Central  Google Scholar 

16.

Koenig JE, Spor A, Scalfone N, Fricker AD, Stombaugh J, Knight R, et al. Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci U S A. 2011;108(Suppl 1):4578–85.

CAS  Article  Google Scholar 

17.

Dominguez-Bello MG, Costello EK, Contreras M, Makris M, Hidalgo G, Fierer N, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A. 2010;107(26):11971–5. https://doi.org/10.1073/pnas.1002601107.

Article  PubMed  PubMed Central  Google Scholar 

18.

Dominguez-Bello MG, Blaser MJ, Ley RE, Knight R. Development of the human gastrointestinal microbiota and insights from high-throughput sequencing. Gastroenterology. 2011;140(6):1713–9. https://doi.org/10.1053/j.gastro.2011.02.011.

CAS  Article  PubMed  Google Scholar 

19.

Zeissig S, Blumberg RS. Life at the beginning: perturbation of the microbiota by antibiotics in early life and its role in health and disease. Nat Immunol. 2014;15(4):307–10. https://doi.org/10.1038/ni.2847.

CAS  Article  PubMed  Google Scholar 

20.

Agace WW, McCoy KD. Regionalized development and maintenance of the intestinal adaptive immune landscape. Immunity. 2017;46(4):532–48. https://doi.org/10.1016/j.immuni.2017.04.004.

CAS  Article  PubMed  Google Scholar 

21.

Vallianou NG, Geladari E, Kounatidis D. Microbiome and hypertension: where are we now? J Cardiovasc Med. 2020;21(2):83–8. https://doi.org/10.2459/JCM.0000000000000900.

CAS  Article  Google Scholar 

22.

•• Vallianou N, Stratigou T, Christodoulatos GS, Tsigalou C, Dalamaga M. Probiotics, Prebiotics, synbiotics, postbiotics, and obesity: current evidence, controversies, and perspectives. Curr Obes Rep. 2020;9(3):179–92. https://doi.org/10.1007/s13679-020-00379-wIn this review, current evidence on gut microbiome and obesity, the role of probiotics, prebiotics, synbiotics, and postbiotics in obesity prevention and management and their main limitations, challenges, and controversies of their use are discussed.

Article  PubMed  Google Scholar 

23.

• Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56(7):1761–72. https://doi.org/10.2337/db06-1491In this study, authors have shown that the LPS-CD14 system is implicated in the development of diabetes and obesity in mice, and they have proposed that lowering plasma LPS levels could be useful in preventing metabolic disorders.

CAS  Article  Google Scholar 

24.

• Tamburini S, Shen N, Wu HC, Clemente JC. The microbiome in early life: implications for health outcomes. Nat Med. 2016;22(7):713–22. https://doi.org/10.1038/nm.4142In this review, prenatal as well as postnatal factors that affect the shaping of the human gut microbiota and its interactions with the immune system are discussed.

CAS  Article  PubMed  Google Scholar 

25.

Charbonneau MR, Blanton LV, DiGiulio DB, Relman DA, Lebrilla CB, Mills DA, et al. A microbial perspective of human developmental biology. Nature. 2016;535(7610):48–55. https://doi.org/10.1038/nature18845.

CAS  Article  PubMed  PubMed Central  Google Scholar 

26.

Vallianou NG, Stratigou T, Tsagarakis S. Microbiome and diabetes: where are we now? Diabetes Res Clin Pract. 2018;146:111–8. https://doi.org/10.1016/j.diabres.2018.10.008.

CAS  Article  PubMed  Google Scholar 

27.

Faith JJ, Guruge JL, Charbonneau M, Subramanian S, Seedorf H, Goodman AL, et al. The long-term stability of the human gut microbiota. Science. 2013;341(6141):1237439. https://doi.org/10.1126/science.1237439.

CAS  Article  PubMed  PubMed Central  Google Scholar 

28.

Backhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A. 2004;101(44):15718–23. https://doi.org/10.1073/pnas.0407076101.

CAS  Article  PubMed  PubMed Central  Google Scholar 

29.

Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444(7122):1027–31. https://doi.org/10.1038/nature05414.

Article  PubMed  Google Scholar 

30.

Turnbaugh PJ, Backhed F, Fulton L, Gordon JI. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe. 2008;3(4):213–23. https://doi.org/10.1016/j.chom.2008.02.015.

CAS  Article  PubMed  PubMed Central  Google Scholar 

31.

Liu R, Hong J, Xu X, Feng Q, Zhang D, Gu Y, et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nat Med. 2017;23:859–68. https://doi.org/10.1038/nm.4358.

CAS  Article  PubMed  Google Scholar 

32.

Parnell JL, Reimer RA. Prebiotic fiber modulation of the gut microbiota improves risk factors for obesity and the metabolic syndrome. Gut Microbes. 2012;3(1):29–34. https://doi.org/10.4161/gmic.19246.

Article  PubMed  Google Scholar 

33.

Tims S, Derom C, Jonkers DM, Vlietinck R, Saris WH, Kleerebezel M, et al. Microbiota conservation and BMI signatures in adult monozygotic twins. ISME J. 2013;7:707–17. https://doi.org/10.1038/ismej.2012.146.

CAS  Article  PubMed  Google Scholar 

34.

Bansal T, Alaniz RC, Wood TK, Jayaraman A. The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation. Proc Natl Acad Sci U S A. 2010;107:228–33. https://doi.org/10.1073/pnas.0906112107.

Article  PubMed  Google Scholar 

35.

Schwiertz A, Taras D, Schafer K, Beijer S, Bos NA, Donus C, et al. Microbiota and SCFA in lean and overweight healthy subjects. Obesity. 2010;18(1):190–5. https://doi.org/10.1038/oby.2009.167.

Article  PubMed  Google Scholar 

36.

Walters WA, Xu Z, Knight R. Meta-analyses of human gut microbes associated with obesity and IBD. Febbs Lett. 2014;588(22):4223–33. https://doi.org/10.1016/j.febslet.2014.09.039.

CAS  Article  Google Scholar 

37.

Sze MA, Schloss PD. Looking for a signal in the noise: revisiting obesity and the microbiome. mBio. 2016;7(4):e01018–6. https://doi.org/10.1128/mBio.01018-16.

Article  PubMed  PubMed Central  Google Scholar 

38.

Fan Y, Pedersen O. Human gut microbiota in metabolic health and disease. Nat Rev Microbiol. 2021;19(1):55–71. https://doi.org/10.1038/s41579-020-0433-9.

CAS  Article  PubMed  Google Scholar 

39.

Klancic T, Reimer RA. Gut microbiota and obesity: Impact of antibiotics and prebiotics and potential for musculoskeletal health. J Sport Health Sci. 2020;9(2):110–8. https://doi.org/10.1016/j.jshs.2019.04.004.

Article  P

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