The Role of Mitochondrial Adaptation and Metabolic Flexibility in the Pathophysiology of Obesity and Insulin Resistance: an Updated Overview

1.

Malik VS, Willet WC, Hu FB. Nearly a decade on - trends, risk factors and policy implications in global obesity. Nat Rev Endocrinol. 2020;16:615–6. https://doi.org/10.1038/s41574-020-00411-y.

Article  PubMed  Google Scholar 

2.

Guarisco G, Leonetti F. Covid-19 and diabesity: when a pandemia cross another pandemia. Eating and Weight Disorders: EWD. 2020:1–4. https://doi.org/10.1007/s40519-020-00958-9.

3.

Tsilingiris D, Liatis S, Dalamaga M, Kokkinos A. The fight against obesity escalates: new drugs on the horizon and metabolic implications. Curr Obes Rep. 2020;9:136–49. https://doi.org/10.1007/s13679-020-00378-x.

Article  PubMed  Google Scholar 

4.

Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA, Ogurtsova K, Shaw JE, Bright D, Williams R, IDF Diabetes Atlas Committee Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract 2019;157:107843. https://doi.org/10.1016/j.diabres.2019.107843

5.

Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology (Baltimore, Md). 2016;64:73–84. https://doi.org/10.1002/hep.28431.

Article  Google Scholar 

6.

Hill JO, Wyatt HR, Peters JC. Energy balance and obesity. Circulation. 2012;126:126–32. https://doi.org/10.1161/circulationaha.111.087213.

Article  PubMed  PubMed Central  Google Scholar 

7.

Corpeleijn E, Saris WH, Blaak EE. Metabolic flexibility in the development of insulin resistance and type 2 diabetes: effects of lifestyle. Obesity Reviews: an official journal of the International Association for the Study of Obesity. 2009;10:178–93. https://doi.org/10.1111/j.1467-789X.2008.00544.x.

CAS  Article  Google Scholar 

8.

Gastaldelli A. Insulin resistance and reduced metabolic flexibility: cause or consequence of NAFLD? Clinical Science (London, England: 1979). 2017;131:2701–4. https://doi.org/10.1042/cs20170987.

CAS  Article  Google Scholar 

9.

Wikström M, Sharma V, Kaila VR, Hosler JP, Hummer G. New perspectives on proton pumping in cellular respiration. Chem Rev. 2015;115:2196–221. https://doi.org/10.1021/cr500448t.

CAS  Article  PubMed  Google Scholar 

10.

Cogliati S, Enriquez JA, Scorrano L. Mitochondrial cristae: where beauty meets functionality. Trends Biochem Sci. 2016;41:261–73. https://doi.org/10.1016/j.tibs.2016.01.001.

CAS  Article  PubMed  Google Scholar 

11.

Osellame LD, Blacker TS, Duchen MR. Cellular and molecular mechanisms of mitochondrial function. Best Pract Res Clin Endocrinol Metab. 2012;26:711–23. https://doi.org/10.1016/j.beem.2012.05.003.

CAS  Article  PubMed  PubMed Central  Google Scholar 

12.

Newman JC, Verdin E. β-Hydroxybutyrate: a signaling metabolite. Annu Rev Nutr. 2017;37:51–76. https://doi.org/10.1146/annurev-nutr-071816-064916.

CAS  Article  PubMed  PubMed Central  Google Scholar 

13.

Tait SW, Green DR. Mitochondria and cell signalling. J Cell Sci. 2012;125:807–15. https://doi.org/10.1242/jcs.099234.

CAS  Article  PubMed  PubMed Central  Google Scholar 

14.

Wang C, Youle RJ. The role of mitochondria in apoptosis*. Annu Rev Genet. 2009;43:95–118. https://doi.org/10.1146/annurev-genet-102108-134850.

CAS  Article  PubMed  PubMed Central  Google Scholar 

15.

Smith RL, Soeters MR, Wüst RCI, Houtkooper RH. Metabolic flexibility as an adaptation to energy resources and requirements in health and disease. Endocr Rev. 2018;39:489–517. https://doi.org/10.1210/er.2017-00211.

Article  PubMed  PubMed Central  Google Scholar 

16.

Galgani JE, Moro C, Ravussin E. Metabolic flexibility and insulin resistance. Am J Phys Endocrinol Metab. 2008;295:E1009–17. https://doi.org/10.1152/ajpendo.90558.2008.

CAS  Article  Google Scholar 

17.

Muoio DM. Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock. Cell. 2014;159:1253–62. https://doi.org/10.1016/j.cell.2014.11.034.

CAS  Article  PubMed  PubMed Central  Google Scholar 

18.

Burke SJ, Batdorf HM, Huang TY, Jackson JW, Jones KA, Martin TM, et al. One week of continuous corticosterone exposure impairs hepatic metabolic flexibility, promotes islet β-cell proliferation, and reduces physical activity in male C57BL/6 J mice. J Steroid Biochem Mol Biol. 2019;195:105468. https://doi.org/10.1016/j.jsbmb.2019.105468.

CAS  Article  PubMed  PubMed Central  Google Scholar 

19.

Lee S, Rivera-Vega M, Alsayed HM, Boesch C, Libman I. Metabolic inflexibility and insulin resistance in obese adolescents with non-alcoholic fatty liver disease. Pediatr Diabetes. 2015;16:211–8. https://doi.org/10.1111/pedi.12141.

CAS  Article  PubMed  Google Scholar 

20.

Thyfault JP, Rector RS, Noland RC. Metabolic inflexibility in skeletal muscle: a prelude to the cardiometabolic syndrome? Journal of the Cardiometabolic Syndrome. 2006;1:184–9. https://doi.org/10.1111/j.1559-4564.2006.05629.x.

Article  PubMed  Google Scholar 

21.

Ukropcova B, McNeil M, Sereda O, de Jonge L, Xie H, Bray GA, et al. Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor. J Clin Invest. 2005;115:1934–41. https://doi.org/10.1172/jci24332.

CAS  Article  PubMed  PubMed Central  Google Scholar 

22.

Jørgensen W, Rud KA, Mortensen OH, Frandsen L, Grunnet N, Quistorff B. Your mitochondria are what you eat: a high-fat or a high-sucrose diet eliminates metabolic flexibility in isolated mitochondria from rat skeletal muscle. Physiological Reports. 2017;5. https://doi.org/10.14814/phy2.13207.

23.

Medeiros DM. Assessing mitochondria biogenesis. Methods (San Diego, Calif). 2008;46:288–94. https://doi.org/10.1016/j.ymeth.2008.09.026.

CAS  Article  Google Scholar 

24.

D'Erchia AM, Atlante A, Gadaleta G, Pavesi G, Chiara M, De Virgilio C, et al. Tissue-specific mtDNA abundance from exome data and its correlation with mitochondrial transcription, mass and respiratory activity. Mitochondrion. 2015;20:13–21. https://doi.org/10.1016/j.mito.2014.10.005.

CAS  Article  PubMed  Google Scholar 

25.

Chiappini F, Barrier A, Saffroy R, Domart MC, Dagues N, Azoulay D, et al. Exploration of global gene expression in human liver steatosis by high-density oligonucleotide microarray. Laboratory Investigation; a journal of technical methods and pathology. 2006;86:154–65. https://doi.org/10.1038/labinvest.3700374.

CAS  Article  PubMed  Google Scholar 

26.

Larsen S, Nielsen J, Hansen CN, Nielsen LB, Wibrand F, Stride N, et al. Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects. J Physiol. 2012;590:3349–60. https://doi.org/10.1113/jphysiol.2012.230185.

CAS  Article  PubMed  PubMed Central  Google Scholar 

27.

Vigelsø A, Andersen NB, Dela F. The relationship between skeletal muscle mitochondrial citrate synthase activity and whole body oxygen uptake adaptations in response to exercise training. International Journal of Physiology, Pathophysiology and Pharmacology. 2014;6:84–101.

PubMed  PubMed Central  Google Scholar 

28.

Christe M, Hirzel E, Lindinger A, Kern B, von Flüe M, Peterli R, et al. Obesity affects mitochondrial citrate synthase in human omental adipose tissue. ISRN Obesity. 2013;2013:826027–8. https://doi.org/10.1155/2013/826027.

CAS  Article  PubMed  PubMed Central  Google Scholar 

29.

Laye MJ, Rector RS, Warner SO, Naples SP, Perretta AL, Uptergrove GM, et al. Changes in visceral adipose tissue mitochondrial content with type 2 diabetes and daily voluntary wheel running in OLETF rats. J Physiol. 2009;587:3729–39. https://doi.org/10.1113/jphysiol.2009.172601.

CAS  Article  PubMed  PubMed Central  Google Scholar 

30.

Koliaki C, Szendroedi J, Kaul K, Jelenik T, Nowotny P, Jankowiak F, et al. Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis. Cell Metab. 2015;21:739–46. https://doi.org/10.1016/j.cmet.2015.04.004.

CAS  Article  PubMed  Google Scholar 

31.

Lee K, Haddad A, Osme A. Hepatic mitochondrial defects in a nonalcoholic fatty liver disease mouse model are associated with increased degradation of oxidative phosphorylation subunits. 2018;17:2371–86. https://doi.org/10.1074/mcp.RA118.000961.

32.

Koekemoer TC, Oelofsen W. Properties of porcine white adipose tissue and liver mitochondrial subpopulations. Int J Biochem Cell Biol. 2001;33:889–901. https://doi.org/10.1016/s1357-2725(01)00064-4.

CAS  Article  PubMed  Google Scholar 

33.

Jornayvaz FR, Shulman GI. Regulation of mitochondrial biogenesis. Essays Biochem. 2010;47:69–84. https://doi.org/10.1042/bse0470069.

CAS  Article  PubMed  Google Scholar 

34.

Scarpulla RC, Vega RB, Kelly DP. Transcriptional integration of mitochondrial biogenesis. Trends Endocrinol Metab. 2012;23:459–66. https://doi.org/10.1016/j.tem.2012.06.006.

CAS  Article  PubMed  PubMed Central  Google Scholar 

35.

Kang D, Kim SH, Hamasaki N. Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functions. Mitochondrion. 2007;7:39–44. https://doi.org/10.1016/j.mito.2006.11.017.

CAS  Article  PubMed  Google Scholar 

36.

Lin J, Handschin C, Spiegelman BM. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 2005;1:361–70. https://doi.org/10.1016/j.cmet.2005.05.004.

CAS  Article  PubMed  Google Scholar 

37.

Gao AW, Cantó C, Houtkooper RH. Mitochondrial response to nutrient availability and its role in metabolic disease. EMBO Mol Med. 2014;6:580–9. https://doi.org/10.1002/emmm.201303782.

CAS  Article  PubMed  PubMed Central  Google Scholar 

38.

Tang BL. Sirt1 and the mitochondria. Molecules and Cells. 2016;39:87–95. https://doi.org/10.14348/molcells.2016.2318.

CAS  Article  PubMed  PubMed Central  Google Scholar 

39.

Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 2005;434:113–8. https://doi.org/10.1038/nature03354.

CAS  Article  PubMed 

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